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Kyat1 kynurenine aminotransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 70266, updated on 11-Apr-2024

Summary

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Official Symbol
Kyat1provided by MGI
Official Full Name
kynurenine aminotransferase 1provided by MGI
Primary source
MGI:MGI:1917516
See related
Ensembl:ENSMUSG00000039648 AllianceGenome:MGI:1917516
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gtk; Kat1; KatI; Ccbl1; 2010009K05Rik
Summary
Predicted to enable cysteine-S-conjugate beta-lyase activity; protein homodimerization activity; and transaminase activity. Acts upstream of or within response to bacterium. Predicted to be located in cytosol. Predicted to be active in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; integumental system; respiratory system; and sensory organ. Orthologous to human KYAT1 (kynurenine aminotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 63.7), liver E18 (RPKM 19.9) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Kyat1 in Genome Data Viewer
Location:
2 B; 2 21.31 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30075136..30096307, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30185124..30206295, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 31080 Neighboring gene STARR-positive B cell enhancer ABC_E2609 Neighboring gene endonuclease G Neighboring gene SPOUT domain containing methyltransferase 1 Neighboring gene predicted gene, 31201 Neighboring gene STARR-seq mESC enhancer starr_04089 Neighboring gene STARR-seq mESC enhancer starr_04090 Neighboring gene RIKEN cDNA 1700084E18 gene Neighboring gene STARR-positive B cell enhancer ABC_E7804 Neighboring gene STARR-seq mESC enhancer starr_04091 Neighboring gene leucine rich repeat containing 8A VRAC subunit A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. High resolution crystal structures of human kynurenine aminotransferase-I bound to PLP cofactor, and in complex with aminooxyacetate. Nadvi NA, et al. Protein Sci, 2017 Apr. PMID 28097769, Free PMC Article
  2. Thermal stability, pH dependence and inhibition of four murine kynurenine aminotransferases. Han Q, et al. BMC Biochem, 2010 May 19. PMID 20482848, Free PMC Article
  3. Characterization of kynurenine aminotransferase III, a novel member of a phylogenetically conserved KAT family. Yu P, et al. Gene, 2006 Jan 3. PMID 16376499
  4. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
  5. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-S-conjugate beta-lyase activity ISO
Inferred from Sequence Orthology
more info
  
enables glutamine-phenylpyruvate transaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables kynurenine-oxoglutarate transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kynurenine-oxoglutarate transaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-kynurenine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in kynurenine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in pyruvate metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kynurenine--oxoglutarate transaminase 1
Names
cysteine conjugate-beta lyase 1
cysteine-S-conjugate beta-lyase
cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase)
glutamine transaminase K
glutamine--phenylpyruvate transaminase
kynurenine aminotransferase I
kynurenine--oxoglutarate transaminase I
NP_001343403.1
NP_001343404.1
NP_765992.2
XP_006498378.1
XP_006498380.1
XP_030107921.1
XP_036018454.1
XP_036018455.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356474.1 → NP_001343403.1  kynurenine--oxoglutarate transaminase 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AI182306, AK088404, AL845258
    Consensus CDS
    CCDS15874.1
    UniProtKB/Swiss-Prot
    Q8BTY1, Q8BY27
    UniProtKB/TrEMBL
    A2AQY9, Q05CI8
    Related
    ENSMUSP00000038612.4, ENSMUST00000044038.10
    Conserved Domains (1) summary
    cl27741
    Location:23 → 420
    Aminotran_1_2; Aminotransferase class I and II

  2. NM_001356475.1 → NP_001343404.1  kynurenine--oxoglutarate transaminase 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AK031511, AL845258
    UniProtKB/TrEMBL
    A2AQY9
    Related
    ENSMUST00000148555.8
    Conserved Domains (1) summary
    PRK08912
    Location:3 → 362
    PRK08912; aminotransferase

  3. NM_172404.3 → NP_765992.2  kynurenine--oxoglutarate transaminase 1 isoform a

    See identical proteins and their annotated locations for NP_765992.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AL845258
    Consensus CDS
    CCDS15874.1
    UniProtKB/Swiss-Prot
    Q8BTY1, Q8BY27
    UniProtKB/TrEMBL
    A2AQY9, Q05CI8
    Related
    ENSMUSP00000109293.3, ENSMUST00000113663.9
    Conserved Domains (1) summary
    cl27741
    Location:23 → 420
    Aminotran_1_2; Aminotransferase class I and II

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    30075136..30096307 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498315.2 → XP_006498378.1  kynurenine--oxoglutarate transaminase 1 isoform X1

    Conserved Domains (1) summary
    PRK08912
    Location:218 → 569
    PRK08912; aminotransferase

  2. XM_030252061.2 → XP_030107921.1  kynurenine--oxoglutarate transaminase 1 isoform X4

    UniProtKB/TrEMBL
    A2AQY8
    Conserved Domains (1) summary
    PRK08912
    Location:2 → 333
    PRK08912; aminotransferase

  3. XM_036162561.1 → XP_036018454.1  kynurenine--oxoglutarate transaminase 1 isoform X3

    UniProtKB/TrEMBL
    A2AQY9
    Conserved Domains (1) summary
    PRK08912
    Location:3 → 362
    PRK08912; aminotransferase

  4. XM_036162562.1 → XP_036018455.1  kynurenine--oxoglutarate transaminase 1 isoform X4

    UniProtKB/TrEMBL
    A2AQY8
    Conserved Domains (1) summary
    PRK08912
    Location:2 → 333
    PRK08912; aminotransferase

  5. XM_006498317.4 → XP_006498380.1  kynurenine--oxoglutarate transaminase 1 isoform X2

    Conserved Domains (1) summary
    PRK08912
    Location:25 → 391
    PRK08912; aminotransferase

RNA

  1. XR_003953717.1 RNA Sequence

  2. XR_001783175.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BTY1.1 GenPept UniProtKB/Swiss-Prot:Q8BTY1

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