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Chp2 calcineurin-like EF hand protein 2 [ Mus musculus (house mouse) ]

Gene ID: 70261, updated on 5-Mar-2024

Summary

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Official Symbol
Chp2provided by MGI
Official Full Name
calcineurin-like EF hand protein 2provided by MGI
Primary source
MGI:MGI:1917511
See related
Ensembl:ENSMUSG00000030865 AllianceGenome:MGI:1917511
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cbhp2; 2010110P09Rik
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in several processes, including cellular response to calcium ion; positive regulation of calcineurin-NFAT signaling cascade; and positive regulation of protein import into nucleus. Predicted to act upstream of or within regulation of pH and sodium ion transport. Predicted to be located in cytoplasm; nucleus; and plasma membrane. Is expressed in bone marrow; genitourinary system; spinal cord; and submandibular gland. Orthologous to human CHP2 (calcineurin like EF-hand protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum adult (RPKM 116.8), large intestine adult (RPKM 85.0) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Chp2 in Genome Data Viewer
Location:
7 F2; 7 65.62 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (121807839..121823094)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (122208621..122222539)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:129303635-129303822 Neighboring gene polo like kinase 1 Neighboring gene endoplasmic reticulum to nucleus signalling 2 Neighboring gene STARR-seq mESC enhancer starr_20073 Neighboring gene predicted gene, 51496 Neighboring gene predicted gene, 29903 Neighboring gene STARR-positive B cell enhancer mm9_chr7:129395264-129395565 Neighboring gene predicted gene, 23614

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of calcineurin B homologous protein 2 protects serum deprivation-induced cell death by serum-independent activation of Na+/H+ exchanger. Pang T, et al. J Biol Chem, 2002 Nov 15. PMID 12226101
  2. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
  3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of sodium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of pH ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within sodium ion transport ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
calcineurin B homologous protein 2
Names
hepatocellular carcinoma-associated antigen 520 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027363.1 → NP_081639.1  calcineurin B homologous protein 2

    See identical proteins and their annotated locations for NP_081639.1

    Status: PROVISIONAL

    Source sequence(s)
    BC119204
    Consensus CDS
    CCDS21814.1
    UniProtKB/Swiss-Prot
    Q0VEK2, Q9D869
    Related
    ENSMUSP00000033152.5, ENSMUST00000033152.5
    Conserved Domains (1) summary
    COG5126
    Location:23 → 179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    121807839..121823094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241899.2 → XP_011240201.1  calcineurin B homologous protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011240201.1

    UniProtKB/Swiss-Prot
    Q0VEK2, Q9D869
    Conserved Domains (1) summary
    COG5126
    Location:23 → 179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D869.4 GenPept UniProtKB/Swiss-Prot:Q9D869

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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