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Bhlhb9 basic helix-loop-helix domain containing, class B9 [ Mus musculus (house mouse) ]

Gene ID: 70237, updated on 11-Apr-2024

Summary

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Official Symbol
Bhlhb9provided by MGI
Official Full Name
basic helix-loop-helix domain containing, class B9provided by MGI
Primary source
MGI:MGI:1917487
See related
Ensembl:ENSMUSG00000072964 AllianceGenome:MGI:1917487
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gprasp3; 2700087I09Rik
Summary
Enables protein homodimerization activity. Involved in learning or memory; negative regulation of neuron apoptotic process; and positive regulation of nervous system development. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including central nervous system; sensory organ; skeleton; submandibular gland primordium; and trigeminal nerve. Orthologous to several human genes including ARMCX5-GPRASP2 (ARMCX5-GPRASP2 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 18.6), CNS E14 (RPKM 15.2) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X F1; X 57.31 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (134742388..134791828)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (135841639..135891081)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor associated sorting protein 1 Neighboring gene RAB18, member RAS oncogene family pseudogene Neighboring gene microRNA 1970 Neighboring gene STARR-seq mESC enhancer starr_47971 Neighboring gene G protein-coupled receptor associated sorting protein 2 Neighboring gene STARR-seq mESC enhancer starr_47972 Neighboring gene predicted gene, 31214 Neighboring gene adipocyte-related X-chromosome expressed sequence 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Brain-site-specific proteome changes induced by neuronal P60TRP expression. Manavalan A, et al. Neurosignals, 2013. PMID 23391701
  2. Neuronal p60TRP expression modulates cardiac capacity. Mishra M, et al. J Proteomics, 2012 Feb 16. PMID 22172954
  3. P60TRP interferes with the GPCR/secretase pathway to mediate neuronal survival and synaptogenesis. Mishra M, et al. J Cell Mol Med, 2011 Nov. PMID 21199326, Free PMC Article
  4. A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice. Zhou J, et al. Biol Reprod, 2013 Jun. PMID 23677977, Free PMC Article
  5. A genomic atlas of mouse hypothalamic development. Shimogori T, et al. Nat Neurosci, 2010 Jun. PMID 20436479, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in learning or memory IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of dendritic spine morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of neurogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
G protein-coupled receptor associated sorting protein 3
Names
protein BHLHB9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098222.2 → NP_001091692.1  G protein-coupled receptor associated sorting protein 3

    See identical proteins and their annotated locations for NP_001091692.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL683822
    Consensus CDS
    CCDS30410.1
    UniProtKB/Swiss-Prot
    Q3U0C1, Q69ZD0, Q6PB60
    Related
    ENSMUSP00000137213.2, ENSMUST00000180025.8
    Conserved Domains (1) summary
    pfam04826
    Location:306 → 533
    Arm_2; Armadillo-like

  2. NM_198161.3 → NP_937804.1  G protein-coupled receptor associated sorting protein 3

    See identical proteins and their annotated locations for NP_937804.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL683822
    Consensus CDS
    CCDS30410.1
    UniProtKB/Swiss-Prot
    Q3U0C1, Q69ZD0, Q6PB60
    Related
    ENSMUSP00000068067.8, ENSMUST00000068755.14
    Conserved Domains (1) summary
    pfam04826
    Location:306 → 533
    Arm_2; Armadillo-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    134742388..134791828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247760.1 → XP_011246062.1  G protein-coupled receptor associated sorting protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011246062.1

    UniProtKB/Swiss-Prot
    Q3U0C1, Q69ZD0, Q6PB60
    Conserved Domains (1) summary
    pfam04826
    Location:306 → 533
    Arm_2; Armadillo-like

  2. XM_006528608.3 → XP_006528671.1  G protein-coupled receptor associated sorting protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006528671.1

    UniProtKB/Swiss-Prot
    Q3U0C1, Q69ZD0, Q6PB60
    Conserved Domains (1) summary
    pfam04826
    Location:306 → 533
    Arm_2; Armadillo-like

  3. XM_036162091.1 → XP_036017984.1  G protein-coupled receptor associated sorting protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q3U0C1, Q69ZD0, Q6PB60
    Conserved Domains (1) summary
    pfam04826
    Location:306 → 533
    Arm_2; Armadillo-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PB60.1 GenPept UniProtKB/Swiss-Prot:Q6PB60

Gene LinkOut

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