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Poc1a POC1 centriolar protein A [ Mus musculus (house mouse) ]

Gene ID: 70235, updated on 18-Apr-2024

Summary

Official Symbol
Poc1aprovided by MGI
Official Full Name
POC1 centriolar protein Aprovided by MGI
Primary source
MGI:MGI:1917485
See related
Ensembl:ENSMUSG00000023345 AllianceGenome:MGI:1917485
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
cha; Wdr51a; 2510040D07Rik
Summary
Acts upstream of or within several processes, including growth plate cartilage chondrocyte development; non-motile cilium assembly; and positive regulation of centrosome duplication. Located in centrosome and cytoplasm. Is expressed in metanephros; ovary; submandibular gland; testis; and thyroid gland. Orthologous to human POC1A (POC1 centriolar protein A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 26.3), liver E14.5 (RPKM 10.9) and 25 other tissues See more
Orthologs
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Genomic context

Location:
9 F1; 9 57.46 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (106156177..106227721)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (106279443..106350522)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930500F10 gene Neighboring gene aminolevulinic acid synthase 1 Neighboring gene predicted gene, 33564 Neighboring gene VISTA enhancer mm1475 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:106274227-106274380 Neighboring gene STARR-positive B cell enhancer ABC_E6800 Neighboring gene dual specificity phosphatase 7 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:106296741-106296928 Neighboring gene predicted gene, 33616 Neighboring gene predicted gene, 46131

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Spontaneous (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centriole ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
POC1 centriolar protein homolog A
Names
WD repeat domain 51A
WD repeat-containing protein 51A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027354.2NP_081630.2  POC1 centriolar protein homolog A

    See identical proteins and their annotated locations for NP_081630.2

    Status: VALIDATED

    Source sequence(s)
    AK011064, BB234823, BE981233, CA557124, CD549942
    Consensus CDS
    CCDS23474.1
    UniProtKB/Swiss-Prot
    Q8JZX3, Q9CY09
    Related
    ENSMUSP00000072064.7, ENSMUST00000072206.14
    Conserved Domains (3) summary
    COG2319
    Location:13301
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:11299
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:2359
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    106156177..106227721
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511831.5XP_006511894.1  POC1 centriolar protein homolog A isoform X3

    Conserved Domains (2) summary
    cd00200
    Location:11299
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:2359
    7WD40; WD40 repeat [structural motif]
  2. XM_036155277.1XP_036011170.1  POC1 centriolar protein homolog A isoform X2

    Conserved Domains (2) summary
    cd00200
    Location:11299
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:2359
    7WD40; WD40 repeat [structural motif]
  3. XM_006511830.5XP_006511893.1  POC1 centriolar protein homolog A isoform X1

    Conserved Domains (3) summary
    cd00200
    Location:11299
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:2359
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:263365
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...