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Ppil3 peptidylprolyl isomerase (cyclophilin)-like 3 [ Mus musculus (house mouse) ]

Gene ID: 70225, updated on 21-Apr-2024

Summary

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Official Symbol
Ppil3provided by MGI
Official Full Name
peptidylprolyl isomerase (cyclophilin)-like 3provided by MGI
Primary source
MGI:MGI:1917475
See related
Ensembl:ENSMUSG00000026035 AllianceGenome:MGI:1917475
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cyp10l; 2310076N22Rik; 2510026K04Rik
Summary
Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein peptidyl-prolyl isomerization. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be part of catalytic step 2 spliceosome. Orthologous to human PPIL3 (peptidylprolyl isomerase like 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 6.4), CNS E14 (RPKM 5.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C1.3; 1 29.1 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58470152..58484878, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58430993..58445591, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:58450605-58450792 Neighboring gene predicted gene, 53481 Neighboring gene basic leucine zipper and W2 domains 1 Neighboring gene STARR-seq mESC enhancer starr_01013 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:58480276-58480459 Neighboring gene STARR-positive B cell enhancer ABC_E5756 Neighboring gene CDC-like kinase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:58501960-58502147 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:58502340-58502523 Neighboring gene Ngg1 interacting factor 3-like 1 (S. pombe) Neighboring gene predicted gene, 23966 Neighboring gene origin recognition complex, subunit 2 Neighboring gene STARR-seq mESC enhancer starr_01014 Neighboring gene STARR-positive B cell enhancer ABC_E3277 Neighboring gene STARR-seq mESC enhancer starr_01015 Neighboring gene predicted gene 15834 Neighboring gene hyccin PI4KA lipid kinase complex subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article
  2. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein peptidyl-prolyl isomerization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
peptidyl-prolyl cis-trans isomerase-like 3
Names
PPIase
cyclophilin-like 3
cyclophilin-like protein PPIL3
rotamase PPIL3
NP_001272755.1
NP_001272756.1
NP_081627.1
NP_081650.2
XP_011236892.1
XP_011236893.1
XP_011236894.1
XP_011236895.1
XP_011236896.1
XP_011236897.1
XP_011236898.1
XP_030098742.1
XP_030098746.1
XP_030098748.1
XP_030098751.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285826.1 → NP_001272755.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform 1

    See identical proteins and their annotated locations for NP_001272755.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest variant and encodes the longest isoform (1). Variants 1, 3, and 4 encode the same protein.
    Source sequence(s)
    AK010207, BB687332, CJ170065, DV043111
    Consensus CDS
    CCDS35579.1
    UniProtKB/Swiss-Prot
    Q812D2, Q9CY23, Q9D6L8
    Related
    ENSMUSP00000112947.2, ENSMUST00000117069.8
    Conserved Domains (1) summary
    cd01928
    Location:1 → 154
    Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...

  2. NM_001285827.1 → NP_001272756.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform 1

    See identical proteins and their annotated locations for NP_001272756.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 3. Variants 1, 3, and 4 encode the same isoform (1).
    Source sequence(s)
    AK010207, BB687332, CJ166559
    Consensus CDS
    CCDS35579.1
    UniProtKB/Swiss-Prot
    Q812D2, Q9CY23, Q9D6L8
    Related
    ENSMUSP00000109988.2, ENSMUST00000114348.8
    Conserved Domains (1) summary
    cd01928
    Location:1 → 154
    Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...

  3. NM_027351.3 → NP_081627.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform 1

    See identical proteins and their annotated locations for NP_081627.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 3. Variants 1, 3, and 4 encode the same isoform (1).
    Source sequence(s)
    AK010207, BB687332, BC060993
    Consensus CDS
    CCDS35579.1
    UniProtKB/Swiss-Prot
    Q812D2, Q9CY23, Q9D6L8
    Related
    ENSMUSP00000080378.6, ENSMUST00000081677.12
    Conserved Domains (1) summary
    cd01928
    Location:1 → 154
    Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...

  4. NM_027374.3 → NP_081650.2  peptidyl-prolyl cis-trans isomerase-like 3 isoform 2

    See identical proteins and their annotated locations for NP_081650.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and its 3' terminal exon extends past a splice site that is used in variant 3. This results in a novel 3' coding region and 3' UTR, compared to variant 3. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC121091, AK010207, AK011000, BB844274, BY288296
    Consensus CDS
    CCDS35580.1
    UniProtKB/Swiss-Prot
    Q9D6L8
    Related
    ENSMUSP00000109984.3, ENSMUST00000114345.9
    Conserved Domains (1) summary
    cd01928
    Location:1 → 120
    Cyclophilin_PPIL3_like; Cyclophilin_PPIL3_like. Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    58470152..58484878 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242882.2 → XP_030098742.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

    UniProtKB/Swiss-Prot
    Q812D2, Q9CY23, Q9D6L8
    Conserved Domains (1) summary
    cd01928
    Location:1 → 154
    Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...

  2. XM_030242886.2 → XP_030098746.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

    UniProtKB/Swiss-Prot
    Q812D2, Q9CY23, Q9D6L8
    Conserved Domains (1) summary
    cd01928
    Location:1 → 154
    Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...

  3. XM_030242891.2 → XP_030098751.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X4

    Conserved Domains (1) summary
    cl00197
    Location:1 → 105
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

  4. XM_030242888.2 → XP_030098748.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

    UniProtKB/Swiss-Prot
    Q812D2, Q9CY23, Q9D6L8
    Conserved Domains (1) summary
    cd01928
    Location:1 → 154
    Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...

  5. XM_011238594.4 → XP_011236896.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

    See identical proteins and their annotated locations for XP_011236896.1

    Conserved Domains (1) summary
    cd01928
    Location:1 → 122
    Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...

  6. XM_011238596.4 → XP_011236898.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X3

    Conserved Domains (1) summary
    cl00197
    Location:1 → 73
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

  7. XM_011238593.4 → XP_011236895.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

    See identical proteins and their annotated locations for XP_011236895.1

    Conserved Domains (1) summary
    cd01928
    Location:1 → 122
    Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...

  8. XM_011238592.4 → XP_011236894.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

    See identical proteins and their annotated locations for XP_011236894.1

    Conserved Domains (1) summary
    cd01928
    Location:1 → 122
    Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...

  9. XM_011238591.4 → XP_011236893.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

    See identical proteins and their annotated locations for XP_011236893.1

    Conserved Domains (1) summary
    cd01928
    Location:1 → 122
    Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...

  10. XM_011238595.4 → XP_011236897.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

    See identical proteins and their annotated locations for XP_011236897.1

    Conserved Domains (1) summary
    cd01928
    Location:1 → 122
    Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...

  11. XM_011238590.4 → XP_011236892.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

    See identical proteins and their annotated locations for XP_011236892.1

    Conserved Domains (1) summary
    cd01928
    Location:1 → 122
    Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D6L8.1 GenPept UniProtKB/Swiss-Prot:Q9D6L8

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