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Med23 mediator complex subunit 23 [ Mus musculus (house mouse) ]

Gene ID: 70208, updated on 16-Apr-2024

Summary

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Official Symbol
Med23provided by MGI
Official Full Name
mediator complex subunit 23provided by MGI
Primary source
MGI:MGI:1917458
See related
Ensembl:ENSMUSG00000019984 AllianceGenome:MGI:1917458
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sno; Sur2; Crsp3; ESTM7; 130kDa; snouty; mKIAA1216; 3000002A17Rik
Summary
Predicted to contribute to ubiquitin protein ligase activity. Acts upstream of or within positive regulation of T cell extravasation and positive regulation of gene expression. Part of mediator complex. Is expressed in several structures, including genitourinary system. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human MED23 (mediator complex subunit 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 13.8), CNS E14 (RPKM 13.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 A4; 10
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (24745889..24789358)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (24869986..24913529)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 1 Neighboring gene STARR-seq mESC enhancer starr_26082 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 3 Neighboring gene STARR-seq mESC enhancer starr_26086 Neighboring gene STARR-seq mESC enhancer starr_26088 Neighboring gene STARR-seq mESC enhancer starr_26089 Neighboring gene STARR-seq mESC enhancer starr_26090 Neighboring gene STARR-positive B cell enhancer ABC_E6826 Neighboring gene predicted gene, 23410 Neighboring gene microRNA 6905 Neighboring gene predicted gene, 40616 Neighboring gene arginase, liver Neighboring gene predicted gene, 36228

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An intellectual disability-related MED23 mutation dysregulates gene expression by altering chromatin conformation and enhancer activities. Yang Y, et al. Nucleic Acids Res, 2023 Mar 21. PMID 36718943, Free PMC Article
  2. Mediator Med23 Regulates Adult Hippocampal Neurogenesis. Chen GY, et al. Front Cell Dev Biol, 2020. PMID 32850819, Free PMC Article
  3. Mediator MED23 regulates inflammatory responses and liver fibrosis. Wang Z, et al. PLoS Biol, 2019 Dec. PMID 31805036, Free PMC Article
  4. The mediator subunit Med23 contributes to controlling T-cell activation and prevents autoimmunity. Sun Y, et al. Nat Commun, 2014 Oct 10. PMID 25301163
  5. ERK phosphorylation of MED14 in promoter complexes during mitogen-induced gene activation by Elk-1. Galbraith MD, et al. Nucleic Acids Res, 2013 Dec. PMID 24049075, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Med23 deficiency reprograms the tumor microenvironment to promote lung tumorigenesis.
    Title: Med23 deficiency reprograms the tumor microenvironment to promote lung tumorigenesis.
  2. An intellectual disability-related MED23 mutation dysregulates gene expression by altering chromatin conformation and enhancer activities.
    Title: An intellectual disability-related MED23 mutation dysregulates gene expression by altering chromatin conformation and enhancer activities.
  3. Med23 supports angiogenesis and maintains vascular integrity through negative regulation of angiopoietin2 expression.
    Title: Med23 supports angiogenesis and maintains vascular integrity through negative regulation of angiopoietin2 expression.
  4. Med23 Regulates Sox9 Expression during Craniofacial Development.
    Title: Med23 Regulates Sox9 Expression during Craniofacial Development.
  5. Study identifies Med23 as an essential transcriptional regulator that controls invariant natural killer T-cells differentiation and terminal maturation.
    Title: Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23.
  6. Findings identify Med23 as a gatekeeper of myeloid potential of HSCs, thus providing unique insights into the relationship among Med23-mediated transcriptional regulations, the myeloid potential of HSCs and HSC activation upon stresses.
    Title: Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells.
  7. MED23 constitutes a molecular node in the regulatory network of anabolic bone formation and related diseases.
    Title: Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development.
  8. Med23 contributes to controlling T-cell activation at the transcriptional level and prevents the development of autoimmunity.
    Title: The mediator subunit Med23 contributes to controlling T-cell activation and prevents autoimmunity.
  9. The hepatic Med23 deletion impaired the Mediator and RNAPII recruitment and attenuated the expression of FOXO1 target genes.
    Title: Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity.
  10. Data show that Kruppel-like transcription factors KLF2 expression is decreased in mediator complex Med23 null thymocytes.
    Title: T-cells null for the MED23 subunit of mediator express decreased levels of KLF2 and inefficiently populate the peripheral lymphoid organs.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within positive regulation of T cell extravasation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of core mediator complex ISO
Inferred from Sequence Orthology
more info
  
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mediator of RNA polymerase II transcription subunit 23
Names
CRSP complex subunit 3
cofactor required for Sp1 transcriptional activation subunit 3
cofactor required for Sp1 transcriptional activation, subunit 3 (130kD)
mSur-2
protein sur-2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166416.2 → NP_001159888.2  mediator of RNA polymerase II transcription subunit 23 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC159502
    Consensus CDS
    CCDS48522.1
    Related
    ENSMUSP00000090316.8, ENSMUST00000092646.13

  2. NM_027347.4 → NP_081623.4  mediator of RNA polymerase II transcription subunit 23 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC159502
    Consensus CDS
    CCDS35871.2
    UniProtKB/Swiss-Prot
    Q6ZPV7, Q80YQ2, Q8CEC3, Q8K587, Q9CXY8
    Related
    ENSMUSP00000020159.10, ENSMUST00000020159.15

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    24745889..24789358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155991.1 → XP_036011884.1  mediator of RNA polymerase II transcription subunit 23 isoform X1

    UniProtKB/TrEMBL
    F8WJB0
    Conserved Domains (1) summary
    pfam11573
    Location:4 → 1278
    Med23; Mediator complex subunit 23
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80YQ2.2 GenPept UniProtKB/Swiss-Prot:Q80YQ2

Gene LinkOut

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