Abhd17c abhydrolase domain containing 17C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abhd17cprovided by MGI
Official Full Name: abhydrolase domain containing 17Cprovided by MGI
Primary source: MGI:MGI:1917428
See related: Ensembl:ENSMUSG00000038459 AllianceGenome:MGI:1917428
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fam108c; Fam108c1; 2210412D01Rik
Summary: Enables palmitoyl-(protein) hydrolase activity. Involved in negative regulation of protein localization to microtubule; positive regulation of protein localization to endosome; and protein depalmitoylation. Located in postsynaptic density. Is expressed in several structures, including alimentary system; cortical plate; cranial ganglion; genitourinary system; and skin. Orthologous to human ABHD17C (abhydrolase domain containing 17C, depalmitoylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in small intestine adult (RPKM 86.1), colon adult (RPKM 84.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 D3; 7 48.35 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (83758564..83801101, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (84109356..84151893, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH138465 (e-PCR)
- UniSTS:220552

RH125397 (e-PCR)
- UniSTS:162219

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables palmitoyl-(protein) hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables palmitoyl-(protein) hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables palmitoyl-(protein) hydrolase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of protein localization to microtubule	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to endosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein depalmitoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein depalmitoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein depalmitoylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynapse organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha/beta hydrolase domain-containing protein 17C

Names: abhydrolase domain-containing protein 17C; abhydrolase domain-containing protein FAM108C1; family with sequence similarity 108, member C; protein ABHD17C

NP_598483.2

EC 3.1.2.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133722.2 → NP_598483.2 alpha/beta hydrolase domain-containing protein 17C

See identical proteins and their annotated locations for NP_598483.2

Status: VALIDATED

Source sequence(s)

AC101659, AK008906, BM943880, BQ033953

Consensus CDS

CCDS21417.2

UniProtKB/Swiss-Prot

Q8VCV1

Related

ENSMUSP00000112988.2, ENSMUST00000117085.2

Conserved Domains (1) summary

COG1073
Location:125 → 317

FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]