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Ankrd60 ankyrin repeat domain 60 [ Mus musculus (house mouse) ]

Gene ID: 70065, updated on 5-Mar-2024

Summary

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Official Symbol
Ankrd60provided by MGI
Official Full Name
ankyrin repeat domain 60provided by MGI
Primary source
MGI:MGI:1917315
See related
Ensembl:ENSMUSG00000027517 AllianceGenome:MGI:1917315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700019A24Rik; 1700030G11Rik
Summary
Orthologous to human ANKRD60 (ankyrin repeat domain 60). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 162.4) See more
Orthologs
human all
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Genomic context

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Location:
2 H4; 2 97.04 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (173410451..173420066, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (173568658..173578273, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ciliary microtubule inner protein 1 Neighboring gene predicted gene, 54093 Neighboring gene protein phosphatase 4, regulatory subunit 1-like, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8799 Neighboring gene STARR-positive B cell enhancer ABC_E7891 Neighboring gene RAB22A, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E648 Neighboring gene microRNA 6340

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Folding landscapes of ankyrin repeat proteins: experiments meet theory. Barrick D, et al. Curr Opin Struct Biol, 2008 Feb. PMID 18243686, Free PMC Article
  2. The ankyrin repeat: a diversity of interactions on a common structural framework. Sedgwick SG, et al. Trends Biochem Sci, 1999 Aug. PMID 10431175
  3. The ankyrin repeat as molecular architecture for protein recognition. Mosavi LK, et al. Protein Sci, 2004 Jun. PMID 15152081, Free PMC Article
  4. Ankyrin repeat: a unique motif mediating protein-protein interactions. Li J, et al. Biochemistry, 2006 Dec 26. PMID 17176038
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 60

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199955.2 → NP_001186884.2  ankyrin repeat domain-containing protein 60 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AL807384
    Related
    ENSMUST00000147693.2
    Conserved Domains (1) summary
    cl28922
    Location:1 → 53
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. NM_027303.2 → NP_081579.2  ankyrin repeat domain-containing protein 60 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL807384
    Consensus CDS
    CCDS50815.1
    UniProtKB/TrEMBL
    A0A6I8MWY2, A6PWV4
    Related
    ENSMUSP00000159317.2, ENSMUST00000239457.2
    Conserved Domains (4) summary
    PHA02875
    Location:59 → 219
    PHA02875; ankyrin repeat protein; Provisional
    sd00045
    Location:108 → 135
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:109 → 187
    Ank_2; Ankyrin repeats (3 copies)
    cl28922
    Location:1 → 53
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    173410451..173420066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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