Trnt1 tRNA nucleotidyl transferase, CCA-adding, 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trnt1provided by MGI
Official Full Name: tRNA nucleotidyl transferase, CCA-adding, 1provided by MGI
Primary source: MGI:MGI:1917297
See related: Ensembl:ENSMUSG00000013736 AllianceGenome:MGI:1917297
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CGI-47; mt-Trat; 2410043H24Rik; 2610044E04Rik; 9830143O18Rik
Summary: Predicted to enable ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity; tRNA binding activity; and tRNA nucleotidyltransferase activity. Predicted to be involved in mitochondrial tRNA 3'-end processing and tRNA 3'-terminal CCA addition. Predicted to act upstream of or within tRNA processing. Located in mitochondrion. Human ortholog(s) of this gene implicated in sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay. Orthologous to human TRNT1 (tRNA nucleotidyl transferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 8.5), cerebellum adult (RPKM 7.3) and 28 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 6 E1; 6 49.24 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (106746099..106759435)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (106769138..106782474)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (1)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

AI987788 (e-PCR)
- UniSTS:178496

RH125992 (e-PCR)
- UniSTS:162704

RH127525 (e-PCR)
- UniSTS:210835

AW108261 (e-PCR)
- UniSTS:179427

RH124706 (e-PCR)
- UniSTS:161528

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables CCA tRNA nucleotidyltransferase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables CCACCA tRNA nucleotidyltransferase activity	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA processing	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial tRNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial tRNA 3'-end processing	ISO Inferred from Sequence Orthology more info
involved_in rescue of stalled ribosome	ISO Inferred from Sequence Orthology more info
involved_in tRNA 3'-terminal CCA addition	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA 3'-terminal CCA addition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tRNA processing	ISO Inferred from Sequence Orthology more info	PubMed
involved_in tRNA surveillance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISA Inferred from Sequence Alignment more info	PubMed
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: CCA tRNA nucleotidyltransferase 1, mitochondrial

Names: mitochondrial tRNA nucleotidyl transferase, CCA-adding; mt CCA-adding enzyme; mt tRNA CCA-diphosphorylase; mt tRNA CCA-pyrophosphorylase; mt tRNA adenylyltransferase; tRNA adenylyltransferase, mitochondrial; tRNA-nucleotidyltransferase 1, mitochondrial

NP_001229287.1

EC 2.7.7.72

NP_001229289.1

EC 2.7.7.72

NP_081572.1

EC 2.7.7.72

XP_006506644.1

EC 2.7.7.72

XP_036008188.1

EC 2.7.7.72

XP_036008189.1

EC 2.7.7.72

XP_036008190.1

EC 2.7.7.72

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001242358.1 → NP_001229287.1 CCA tRNA nucleotidyltransferase 1, mitochondrial isoform a

See identical proteins and their annotated locations for NP_001229287.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AK135791, AK139764, AK152739, BU755617

Consensus CDS

CCDS20397.1

UniProtKB/Swiss-Prot

Q3TKW1, Q3UX99, Q8K1J6, Q920N6, Q9CSX0

Related

ENSMUSP00000060900.10, ENSMUST00000057578.16

Conserved Domains (1) summary

COG0617
Location:40 → 417

PcnB; tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]
NM_001242360.1 → NP_001229289.1 CCA tRNA nucleotidyltransferase 1, mitochondrial isoform b

See identical proteins and their annotated locations for NP_001229289.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.

Source sequence(s)

AC153848, AK135791

Consensus CDS

CCDS57443.1

UniProtKB/Swiss-Prot

Q8K1J6

Related

ENSMUSP00000108873.2, ENSMUST00000113247.8

Conserved Domains (1) summary

COG0617
Location:40 → 203

PcnB; tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]
NM_027296.3 → NP_081572.1 CCA tRNA nucleotidyltransferase 1, mitochondrial isoform a

See identical proteins and their annotated locations for NP_081572.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AK135791, AK139764, BU755617

Consensus CDS

CCDS20397.1

UniProtKB/Swiss-Prot

Q3TKW1, Q3UX99, Q8K1J6, Q920N6, Q9CSX0

Related

ENSMUSP00000108874.2, ENSMUST00000113248.4

Conserved Domains (1) summary

COG0617
Location:40 → 417

PcnB; tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

106746099..106759435

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152296.1 → XP_036008189.1 CCA tRNA nucleotidyltransferase 1, mitochondrial isoform X2

Conserved Domains (1) summary

cl40750
Location:17 → 329

PcnB; tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]
XM_036152295.1 → XP_036008188.1 CCA tRNA nucleotidyltransferase 1, mitochondrial isoform X1

UniProtKB/Swiss-Prot

Q3TKW1, Q3UX99, Q8K1J6, Q920N6, Q9CSX0

Conserved Domains (1) summary

COG0617
Location:40 → 417

PcnB; tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]
XM_006506581.5 → XP_006506644.1 CCA tRNA nucleotidyltransferase 1, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_006506644.1

UniProtKB/Swiss-Prot

Q3TKW1, Q3UX99, Q8K1J6, Q920N6, Q9CSX0

Conserved Domains (1) summary

COG0617
Location:40 → 417

PcnB; tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]
XM_036152297.1 → XP_036008190.1 CCA tRNA nucleotidyltransferase 1, mitochondrial isoform X2

Conserved Domains (1) summary

cl40750
Location:17 → 329

PcnB; tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]