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Mcm10 minichromosome maintenance 10 replication initiation factor [ Mus musculus (house mouse) ]

Gene ID: 70024, updated on 11-Apr-2024

Summary

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Official Symbol
Mcm10provided by MGI
Official Full Name
minichromosome maintenance 10 replication initiation factorprovided by MGI
Primary source
MGI:MGI:1917274
See related
Ensembl:ENSMUSG00000026669 AllianceGenome:MGI:1917274
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410041F14Rik; C330019M07Rik
Summary
Enables enzyme binding activity. Acts upstream of or within cell population proliferation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of replication fork protection complex. Is expressed in several structures, including cerebellum; early conceptus; gonad; immune system; and liver. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MCM10 (minichromosome maintenance 10 replication initiation factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 7.2), CNS E11.5 (RPKM 6.2) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 A1; 2 3.12 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (4995535..5017602, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (4990724..5012791, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03551 Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene upper zone of growth plate and cartilage matrix associated Neighboring gene STARR-positive B cell enhancer ABC_E3357 Neighboring gene optineurin Neighboring gene predicted gene, 39755

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeted disruption of Mcm10 causes defective embryonic cell proliferation and early embryo lethality. Lim HJ, et al. Biochim Biophys Acta, 2011 Oct. PMID 21693137
  2. Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium. Elliott EN, et al. Development, 2015 Jun 15. PMID 26023099, Free PMC Article
  3. RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication. Vannier JB, et al. Science, 2013 Oct 11. PMID 24115439
  4. Atypical E2F repressors and activators coordinate placental development. Ouseph MM, et al. Dev Cell, 2012 Apr 17. PMID 22516201, Free PMC Article
  5. The apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state. Park JY, et al. Development, 2016 Jan 1. PMID 26657772, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic evidence for an essential and non-redundant physiological role of MCM10 during murine peri-implantation development.
    Title: Targeted disruption of Mcm10 causes defective embryonic cell proliferation and early embryo lethality.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication initiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nuclear replication fork IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein MCM10 homolog
Names
minichromosome maintenance deficient 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305259.1 → NP_001292188.1  protein MCM10 homolog

    See identical proteins and their annotated locations for NP_001292188.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC064314
    Consensus CDS
    CCDS15662.1
    UniProtKB/Swiss-Prot
    Q0VBD2, Q505F3, Q8BMJ1, Q8BYA7
    Related
    ENSMUSP00000100050.2, ENSMUST00000102985.8
    Conserved Domains (2) summary
    pfam09329
    Location:398 → 443
    zf-primase; Primase zinc finger
    pfam09332
    Location:544 → 883
    Mcm10; Mcm10 replication factor

  2. NM_027290.3 → NP_081566.2  protein MCM10 homolog

    See identical proteins and their annotated locations for NP_081566.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK030780, BC094576, BE951862
    Consensus CDS
    CCDS15662.1
    UniProtKB/Swiss-Prot
    Q0VBD2, Q505F3, Q8BMJ1, Q8BYA7
    Related
    ENSMUSP00000027980.8, ENSMUST00000027980.8
    Conserved Domains (2) summary
    pfam09329
    Location:398 → 443
    zf-primase; Primase zinc finger
    pfam09332
    Location:544 → 883
    Mcm10; Mcm10 replication factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    4995535..5017602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162558.1 → XP_036018451.1  protein MCM10 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q0VBD2, Q505F3, Q8BMJ1, Q8BYA7
    Conserved Domains (2) summary
    pfam09329
    Location:398 → 443
    zf-primase; Primase zinc finger
    pfam09332
    Location:544 → 883
    Mcm10; Mcm10 replication factor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0VBD2.1 GenPept UniProtKB/Swiss-Prot:Q0VBD2

Gene LinkOut

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