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Nt5dc2 5'-nucleotidase domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 70021, updated on 17-Mar-2024

Summary

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Official Symbol
Nt5dc2provided by MGI
Official Full Name
5'-nucleotidase domain containing 2provided by MGI
Primary source
MGI:MGI:1917271
See related
Ensembl:ENSMUSG00000071547 AllianceGenome:MGI:1917271
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2510015F01Rik
Summary
Predicted to enable 5'-nucleotidase activity. Is expressed in several structures, including alimentary system; brain; craniocervical region bone; neural retina; and urinary system. Orthologous to human NT5DC2 (5'-nucleotidase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 90.6), limb E14.5 (RPKM 86.6) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 B; 14 19.09 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30853046..30861081)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31131089..31139124)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene polybromo 1 Neighboring gene predicted gene 5459 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 5 Neighboring gene STARR-positive B cell enhancer ABC_E934 Neighboring gene stabilin 1 Neighboring gene predicted gene, 52148 Neighboring gene nischarin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Investigation of differentially expressed genes during the development of mouse cerebellum. Kagami Y, et al. Brain Res Gene Expr Patterns, 2001 Aug. PMID 15018818
  2. A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects. Choquet H, et al. Nat Commun, 2021 Jun 14. PMID 34127677, Free PMC Article
  3. Gene expression analysis of the embryonic subplate. Oeschger FM, et al. Cereb Cortex, 2012 Jun. PMID 21862448, Free PMC Article
  4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NT5DC2 knockdown suppresses progression, glycolysis, and neuropathic pain in triple-negative breast cancer by blocking the EGFR pathway.
    Title: NT5DC2 knockdown suppresses progression, glycolysis, and neuropathic pain in triple-negative breast cancer by blocking the EGFR pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
5'-nucleotidase domain-containing protein 2
NP_001361016.1
NP_081565.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374087.1 → NP_001361016.1  5'-nucleotidase domain-containing protein 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC154446
    Consensus CDS
    CCDS88613.1
    UniProtKB/TrEMBL
    A0A2I3BR81, A0A2I3BRL0
    Related
    ENSMUSP00000154475.2, ENSMUST00000227096.2
    Conserved Domains (1) summary
    pfam05761
    Location:97 → 530
    5_nucleotid; 5' nucleotidase family

  2. NM_027289.2 → NP_081565.1  5'-nucleotidase domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_081565.1

    Status: VALIDATED

    Source sequence(s)
    AC154446
    Consensus CDS
    CCDS36852.1
    UniProtKB/TrEMBL
    A0A2I3BQR1, Q91X76
    Related
    ENSMUSP00000087680.5, ENSMUST00000090212.5
    Conserved Domains (1) summary
    pfam05761
    Location:1 → 367
    5_nucleotid; 5' nucleotidase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    30853046..30861081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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