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Cep85 centrosomal protein 85 [ Mus musculus (house mouse) ]

Gene ID: 70012, updated on 5-Mar-2024

Summary

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Official Symbol
Cep85provided by MGI
Official Full Name
centrosomal protein 85provided by MGI
Primary source
MGI:MGI:1917262
See related
Ensembl:ENSMUSG00000037443 AllianceGenome:MGI:1917262
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccdc21; 2410030J07Rik
Summary
Predicted to be involved in negative regulation of protein kinase activity and regulation of mitotic centrosome separation. Predicted to act upstream of or within chromosome segregation. Predicted to be located in several cellular components, including Golgi apparatus; microtubule cytoskeleton; and nucleolus. Predicted to be active in centrosome. Orthologous to human CEP85 (centrosomal protein 85). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 25.3), thymus adult (RPKM 18.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.3; 4 66.5 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (133857169..133914420, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (134129858..134187085, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10264 Neighboring gene UBX domain protein 11 Neighboring gene STARR-seq mESC enhancer starr_11667 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:133677585-133677803 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:133680177-133680360 Neighboring gene SH3 domain binding glutamic acid-rich protein-like 3 Neighboring gene STARR-positive B cell enhancer mm9_chr4:133715471-133715771 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:133742713-133742822 Neighboring gene STARR-positive B cell enhancer ABC_E843 Neighboring gene zona pellucida like domain containing 2 Neighboring gene cation channel, sperm associated 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction. Chen C, et al. J Cell Sci, 2015 Sep 1. PMID 26220856, Free PMC Article
  2. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
  3. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  4. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cep85 is a bona fide Nek2A-binding partner that surrounds the proximal ends of centrioles where it cooperates with PP1gamma (also known as PPP1CC) to antagonize Nek2A
    Title: Characterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in centriole assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in centriole replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic centrosome separation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in pericentriolar material ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
centrosomal protein of 85 kDa
Names
coiled-coil domain containing 21
coiled-coil domain-containing protein 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144527.3 → NP_653110.3  centrosomal protein of 85 kDa

    See identical proteins and their annotated locations for NP_653110.3

    Status: VALIDATED

    Source sequence(s)
    AK085545, AK141103, AV301648, AW123366, BY250554
    Consensus CDS
    CCDS18765.1
    UniProtKB/Swiss-Prot
    Q8BMK0, Q8BUF1, Q8K0E6
    UniProtKB/TrEMBL
    A2A9K3
    Related
    ENSMUSP00000039889.6, ENSMUST00000040271.12
    Conserved Domains (1) summary
    COG1196
    Location:381 → 652
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    133857169..133914420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164407.1 → XP_036020300.1  centrosomal protein of 85 kDa isoform X1

    UniProtKB/Swiss-Prot
    Q8BMK0, Q8BUF1, Q8K0E6
    UniProtKB/TrEMBL
    A2A9K3
    Conserved Domains (1) summary
    COG1196
    Location:381 → 652
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. XM_036164408.1 → XP_036020301.1  centrosomal protein of 85 kDa isoform X2

    UniProtKB/TrEMBL
    A2A9K3
    Conserved Domains (1) summary
    COG1196
    Location:330 → 601
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. XM_036164409.1 → XP_036020302.1  centrosomal protein of 85 kDa isoform X3

    UniProtKB/TrEMBL
    A2A9K3
    Conserved Domains (1) summary
    COG1196
    Location:318 → 589
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BMK0.2 GenPept UniProtKB/Swiss-Prot:Q8BMK0

Gene LinkOut

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