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Chn2 chimerin 2 [ Mus musculus (house mouse) ]

Gene ID: 69993, updated on 5-Mar-2024

Summary

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Official Symbol
Chn2provided by MGI
Official Full Name
chimerin 2provided by MGI
Primary source
MGI:MGI:1917243
See related
Ensembl:ENSMUSG00000004633 AllianceGenome:MGI:1917243
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bch; ARHGAP3; 1700026N20Rik; 4930557O16Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in regulation of GTPase activity. Predicted to be located in synapse. Is expressed in several structures, including central nervous system and retina. Orthologous to human CHN2 (chimerin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 91.1), testis adult (RPKM 53.3) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Chn2 in Genome Data Viewer
Location:
6 B3; 6 26.54 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (54016917..54278797)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (54039932..54301812)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15937 Neighboring gene predicted gene, 33716 Neighboring gene carboxypeptidase, vitellogenic-like Neighboring gene RIKEN cDNA 4921529L05 gene Neighboring gene STARR-seq mESC enhancer starr_15940 Neighboring gene STARR-seq mESC enhancer starr_15942 Neighboring gene RIKEN cDNA 9530036M11 gene Neighboring gene STARR-seq mESC enhancer starr_15947 Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene RIKEN cDNA 9130019P16 gene Neighboring gene predicted gene 15527 Neighboring gene STARR-seq mESC enhancer starr_15949 Neighboring gene STARR-seq mESC enhancer starr_15950 Neighboring gene predicted gene, 34169 Neighboring gene proline rich 15 Neighboring gene WAS/WASL interacting protein family, member 3 Neighboring gene predicted gene, 44026

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The RacGAP β-Chimaerin is essential for cerebellar granule cell migration. Estep JA, et al. Sci Rep, 2018 Jan 12. PMID 29330522, Free PMC Article
  2. A new role of the Rac-GAP β2-chimaerin in cell adhesion reveals opposite functions in breast cancer initiation and tumor progression. Casado-Medrano V, et al. Oncotarget, 2016 May 10. PMID 27058424, Free PMC Article
  3. Beta2-chimaerin binds to EphA receptors and regulates cell migration. Takeuchi S, et al. FEBS Lett, 2009 Apr 17. PMID 19306875
  4. Diacylglycerol kinase gamma interacts with and activates beta2-chimaerin, a Rac-specific GAP, in response to epidermal growth factor. Yasuda S, et al. FEBS Lett, 2007 Feb 6. PMID 17254573
  5. α2-Chimaerin is essential for neural stem cell homeostasis in mouse adult neurogenesis. Su YT, et al. Proc Natl Acad Sci U S A, 2019 Jul 2. PMID 31209021, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. essential for neural stem cell homeostasis in mouse adult neurogenesis
    Title: α2-Chimaerin is essential for neural stem cell homeostasis in mouse adult neurogenesis.
  2. our data redefine the role of beta2-chimaerin as tumor suppressor and provide the first in vivo evidence of a dual function in breast cancer, suppressing tumor initiation but favoring tumor progression.
    Title: A new role of the Rac-GAP β2-chimaerin in cell adhesion reveals opposite functions in breast cancer initiation and tumor progression.
  3. Study demonstrates that Sema3F-dependent inhibition of Rac1 by the Rac-GAP beta2Chn is required for hippocampal infrapyramidal tract pruning.
    Title: The RacGAP β2-Chimaerin selectively mediates axonal pruning in the hippocampus.
  4. the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation
    Title: A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
beta-chimaerin
Names
Rho GTPase-activating protein 3
chimerin (chimaerin) 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163640.1 → NP_001157112.1  beta-chimaerin isoform 2

    See identical proteins and their annotated locations for NP_001157112.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate, upstream transcription initiation site, uses a distinct start codon and contains several additional exons, compared to variant 1. The resulting protein (isoform 2, also referred to as beta2-chimerin) has a much longer and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK131641, BB617538, BB676245, BM935649, BQ175659
    Consensus CDS
    CCDS51778.1
    UniProtKB/TrEMBL
    Q3V2R3
    Related
    ENSMUSP00000035908.8, ENSMUST00000046856.14
    Conserved Domains (3) summary
    cd10352
    Location:52 → 138
    SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
    cd04372
    Location:275 → 468
    RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
    pfam00130
    Location:215 → 267
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  2. NM_001311133.1 → NP_001298062.1  beta-chimaerin isoform 3

    See identical proteins and their annotated locations for NP_001298062.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon and initiates translation from an alternate start codon, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC084220, AI848376, AK006398, AK131641
    Consensus CDS
    CCDS80535.1
    UniProtKB/TrEMBL
    B9EIU7
    Related
    ENSMUSP00000114476.2, ENSMUST00000146114.8
    Conserved Domains (2) summary
    cd04372
    Location:89 → 282
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    cd20857
    Location:24 → 84
    C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins

  3. NM_001311134.1 → NP_001298063.1  beta-chimaerin isoform 4

    See identical proteins and their annotated locations for NP_001298063.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' terminal exon and initiates translation from an alternate start codon, compared to variant 1. It encodes isoform 4, which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC084220, AI848376, AK006398, BU583546
    Consensus CDS
    CCDS80536.1
    UniProtKB/TrEMBL
    B9EIU7, Q3TVA5
    Related
    ENSMUSP00000110043.2, ENSMUST00000114401.8
    Conserved Domains (2) summary
    cd04372
    Location:84 → 277
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    cd20857
    Location:19 → 79
    C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins

  4. NM_023543.2 → NP_076032.2  beta-chimaerin isoform 1

    See identical proteins and their annotated locations for NP_076032.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AK131641, BB676245, BM935649, BQ175659, CX238009
    Consensus CDS
    CCDS20154.1
    UniProtKB/Swiss-Prot
    Q80XD1, Q9D9W2, Q9ER57
    UniProtKB/TrEMBL
    B9EIU7
    Related
    ENSMUSP00000066078.8, ENSMUST00000067741.10
    Conserved Domains (2) summary
    cd04372
    Location:139 → 332
    RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
    pfam00130
    Location:79 → 131
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    54016917..54278797
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152294.1 → XP_036008187.1  beta-chimaerin isoform X1

    UniProtKB/TrEMBL
    B9EIU7
    Conserved Domains (2) summary
    cd04372
    Location:129 → 322
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    cd20857
    Location:64 → 124
    C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins

  2. XM_030255589.2 → XP_030111449.1  beta-chimaerin isoform X3

    Conserved Domains (2) summary
    cd04372
    Location:41 → 234
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    cl00040
    Location:1 → 36
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

  3. XM_006506578.4 → XP_006506641.1  beta-chimaerin isoform X2

    See identical proteins and their annotated locations for XP_006506641.1

    UniProtKB/TrEMBL
    B9EIU7, Q3TVA5
    Related
    ENSMUSP00000110044.3, ENSMUST00000114402.9
    Conserved Domains (2) summary
    cd04372
    Location:84 → 277
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    cd20857
    Location:19 → 79
    C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80XD1.2 GenPept UniProtKB/Swiss-Prot:Q80XD1

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