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Galk2 galactokinase 2 [ Mus musculus (house mouse) ]

Gene ID: 69976, updated on 11-Apr-2024

Summary

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Official Symbol
Galk2provided by MGI
Official Full Name
galactokinase 2provided by MGI
Primary source
MGI:MGI:1917226
See related
Ensembl:ENSMUSG00000027207 AllianceGenome:MGI:1917226
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gk2; 2810017M24Rik
Summary
Predicted to enable galactokinase activity. Predicted to be involved in galactose metabolic process. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain; cardiovascular system; ear; and genitourinary system. Orthologous to human GALK2 (galactokinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 9.1), kidney adult (RPKM 8.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Galk2 in Genome Data Viewer
Location:
2 F1; 2 61.76 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (125701029..125826218)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (125859109..125984298)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene SECIS binding protein 2-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:125602741-125602942 Neighboring gene STARR-positive B cell enhancer ABC_E5976 Neighboring gene STARR-positive B cell enhancer ABC_E7857 Neighboring gene STARR-positive B cell enhancer ABC_E11156 Neighboring gene COP9 signalosome subunit 2 Neighboring gene family with sequence similarity 227, member B Neighboring gene fibroblast growth factor 7 Neighboring gene predicted gene, 26496

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The genetic program of hematopoietic stem cells. Phillips RL, et al. Science, 2000 Jun 2. PMID 10834841
  2. Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Bulusu V, et al. Dev Cell, 2017 Feb 27. PMID 28245920, Free PMC Article
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables N-acetylgalactosamine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables galactokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables galactokinase activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in galactose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
N-acetylgalactosamine kinase
Names
galNAc kinase
NP_001277931.1
NP_780363.1
XP_006500216.1
XP_006500217.1
XP_011238072.1
XP_011238074.1
XP_030107919.1
XP_030107920.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291002.1 → NP_001277931.1  N-acetylgalactosamine kinase isoform a

    See identical proteins and their annotated locations for NP_001277931.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a).
    Source sequence(s)
    AK082521, BC079843, BU698705
    Consensus CDS
    CCDS71134.1
    UniProtKB/Swiss-Prot
    Q68FH4
    UniProtKB/TrEMBL
    Q3U3H5
    Related
    ENSMUSP00000092186.3, ENSMUST00000094604.9
    Conserved Domains (3) summary
    PLN02521
    Location:18 → 456
    PLN02521; galactokinase
    pfam08544
    Location:350 → 413
    GHMP_kinases_C; GHMP kinases C terminal
    pfam10509
    Location:24 → 73
    GalKase_gal_bdg; Galactokinase galactose-binding signature

  2. NM_175154.3 → NP_780363.1  N-acetylgalactosamine kinase isoform b

    See identical proteins and their annotated locations for NP_780363.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AK082521, AL844580
    Consensus CDS
    CCDS16680.1
    UniProtKB/TrEMBL
    Q8BUU7
    Related
    ENSMUSP00000028636.7, ENSMUST00000028636.13
    Conserved Domains (3) summary
    PLN02521
    Location:6 → 445
    PLN02521; galactokinase
    pfam08544
    Location:339 → 402
    GHMP_kinases_C; GHMP kinases C terminal
    pfam10509
    Location:13 → 62
    GalKase_gal_bdg; Galactokinase galactose-binding signature

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    125701029..125826218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252060.1 → XP_030107920.1  N-acetylgalactosamine kinase isoform X3

    UniProtKB/TrEMBL
    Q8BWB2
    Conserved Domains (1) summary
    PLN02521
    Location:6 → 338
    PLN02521; galactokinase

  2. XM_006500153.5 → XP_006500216.1  N-acetylgalactosamine kinase isoform X1

    See identical proteins and their annotated locations for XP_006500216.1

    UniProtKB/TrEMBL
    Q3U728
    Conserved Domains (1) summary
    PLN02521
    Location:2 → 432
    PLN02521; galactokinase

  3. XM_006500154.3 → XP_006500217.1  N-acetylgalactosamine kinase isoform X2

    UniProtKB/TrEMBL
    Q8BWB2
    Conserved Domains (1) summary
    PLN02521
    Location:18 → 349
    PLN02521; galactokinase

  4. XM_011239770.3 → XP_011238072.1  N-acetylgalactosamine kinase isoform X1

    See identical proteins and their annotated locations for XP_011238072.1

    UniProtKB/TrEMBL
    Q3U728
    Conserved Domains (1) summary
    PLN02521
    Location:2 → 432
    PLN02521; galactokinase

  5. XM_011239772.1 → XP_011238074.1  N-acetylgalactosamine kinase isoform X4

    Conserved Domains (1) summary
    PLN02521
    Location:1 → 268
    PLN02521; galactokinase

  6. XM_030252059.1 → XP_030107919.1  N-acetylgalactosamine kinase isoform X1

    UniProtKB/TrEMBL
    Q3U728
    Conserved Domains (1) summary
    PLN02521
    Location:2 → 432
    PLN02521; galactokinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68FH4.1 GenPept UniProtKB/Swiss-Prot:Q68FH4

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