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Mettl18 methyltransferase like 18 [ Mus musculus (house mouse) ]

Gene ID: 69962, updated on 11-Apr-2024

Summary

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Official Symbol
Mettl18provided by MGI
Official Full Name
methyltransferase like 18provided by MGI
Primary source
MGI:MGI:1917212
See related
Ensembl:ENSMUSG00000041396 AllianceGenome:MGI:1917212
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810422O20Rik
Summary
Predicted to enable heat shock protein binding activity and protein-L-histidine N-tele-methyltransferase activity. Predicted to be involved in protein methylation; regulation of gene expression; and regulation of ribosome biogenesis. Predicted to act upstream of or within methylation. Predicted to be located in cytosol and nucleolus. Predicted to be part of protein-containing complex. Orthologous to human METTL18 (methyltransferase like 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 2.4), bladder adult (RPKM 2.0) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Mettl18 in Genome Data Viewer
Location:
1 H2.2; 1 71.3 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (163822458..163824812)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (163994889..163997243)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:165709472-165709665 Neighboring gene STARR-seq mESC enhancer starr_02858 Neighboring gene predicted gene, 51663 Neighboring gene kinesin-associated protein 3 Neighboring gene STARR-seq mESC enhancer starr_02859 Neighboring gene SCY1-like 3 (S. cerevisiae) Neighboring gene FIGNL1 interacting regulator of recombination and mitosis Neighboring gene STARR-positive B cell enhancer ABC_E2015 Neighboring gene STARR-seq mESC enhancer starr_02860 Neighboring gene STARR-seq mESC enhancer starr_02864 Neighboring gene STARR-positive B cell enhancer ABC_E7768 Neighboring gene STARR-positive B cell enhancer ABC_E3322 Neighboring gene STARR-positive B cell enhancer ABC_E10052 Neighboring gene STARR-positive B cell enhancer ABC_E7769 Neighboring gene STARR-positive B cell enhancer ABC_E11099 Neighboring gene STARR-positive B cell enhancer ABC_E11100 Neighboring gene selectin, endothelial cell Neighboring gene selectin, lymphocyte

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-L-histidine N-tele-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-L-histidine N-tele-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-lysine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-histidine methylation, to form tele-methylhistidine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-lysine methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-lysine monomethylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of rRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ribosome biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translational elongation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
histidine protein methyltransferase 1 homolog
Names
methyltransferase-like protein 18
NP_001342061.1
NP_081555.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355132.1 → NP_001342061.1  histidine protein methyltransferase 1 homolog

    Status: VALIDATED

    Source sequence(s)
    AC110499, AK013137, AK139786, BC052693
    Consensus CDS
    CCDS15431.1
    UniProtKB/Swiss-Prot
    Q810I8, Q9CZ09
    Related
    ENSMUSP00000107116.2, ENSMUST00000111490.2
    Conserved Domains (1) summary
    cl17173
    Location:155 → 314
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. NM_027279.3 → NP_081555.2  histidine protein methyltransferase 1 homolog

    See identical proteins and their annotated locations for NP_081555.2

    Status: VALIDATED

    Source sequence(s)
    AC110499, AK139786, BC050143
    Consensus CDS
    CCDS15431.1
    UniProtKB/Swiss-Prot
    Q810I8, Q9CZ09
    Related
    ENSMUSP00000048636.8, ENSMUST00000045694.14
    Conserved Domains (1) summary
    cl17173
    Location:155 → 314
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    163822458..163824812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZ09.2 GenPept UniProtKB/Swiss-Prot:Q9CZ09

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