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Rnf113a1 ring finger protein 113A1 [ Mus musculus (house mouse) ]

Gene ID: 69942, updated on 5-Mar-2024

Summary

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Official Symbol
Rnf113a1provided by MGI
Official Full Name
ring finger protein 113A1provided by MGI
Primary source
MGI:MGI:1917192
See related
Ensembl:ENSMUSG00000036537 AllianceGenome:MGI:1917192
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rnf113a; 2810428C21Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in snoRNA splicing. Predicted to be located in nucleoplasm. Predicted to be part of U2-type precatalytic spliceosome. Is expressed in several structures, including ear; nervous system; and urinary system. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 5. Orthologous to several human genes including RNF113A (ring finger protein 113A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human all
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Genomic context

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Location:
X A3.3; X 21.61 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (36454875..36456120)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (37191222..37192467)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:34666661-34666844 Neighboring gene NFKB activating protein Neighboring gene A kinase anchor protein 14 Neighboring gene predicted gene, 39503 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:34731294-34731403 Neighboring gene NADH:ubiquinone oxidoreductase subunit A1 Neighboring gene predicted gene 9 Neighboring gene reproductive homeobox 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner. Oda M, et al. Genes Dev, 2006 Dec 15. PMID 17182866, Free PMC Article
  2. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of chemokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in snoRNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF113A
NP_705723.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153503.2 → NP_705723.1  E3 ubiquitin-protein ligase RNF113A

    See identical proteins and their annotated locations for NP_705723.1

    Status: VALIDATED

    Source sequence(s)
    AK013178, AL451076, BY320486
    Consensus CDS
    CCDS30072.1
    UniProtKB/TrEMBL
    Q3UJW4, Q8R3P8
    Related
    ENSMUSP00000042569.6, ENSMUST00000046433.7
    Conserved Domains (1) summary
    COG5152
    Location:58 → 320
    COG5152; Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers [General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    36454875..36456120
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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