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Scrn1 secernin 1 [ Mus musculus (house mouse) ]

Gene ID: 69938, updated on 3-Apr-2024

Summary

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Official Symbol
Scrn1provided by MGI
Official Full Name
secernin 1provided by MGI
Primary source
MGI:MGI:1917188
See related
Ensembl:ENSMUSG00000019124 AllianceGenome:MGI:1917188
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SES1; mKIAA0193; 2810019K23Rik; 6330535A03Rik
Summary
Predicted to enable cysteine-type exopeptidase activity and dipeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within exocytosis. Predicted to be located in nuclear membrane. Is expressed in several structures, including central nervous system; olfactory epithelium; peripheral nervous system ganglion; reproductive system; and retina. Orthologous to human SCRN1 (secernin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 16.2), frontal lobe adult (RPKM 12.4) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 B3; 6 26.98 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (54451813..54543332, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (54474794..54566517, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9130019P16 gene Neighboring gene STARR-seq mESC enhancer starr_15949 Neighboring gene STARR-seq mESC enhancer starr_15950 Neighboring gene proline rich 15 Neighboring gene predicted gene, 34169 Neighboring gene WAS/WASL interacting protein family, member 3 Neighboring gene predicted gene, 44026 Neighboring gene predicted gene, 52863 Neighboring gene FK506 binding protein 14 Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 Neighboring gene predicted gene, 34249

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Axonal Regeneration Mediated by a Novel Axonal Guidance Pair, Galectin-1 and Secernin-1. Yang X, et al. Mol Neurobiol, 2023 Mar. PMID 36437381
  2. The role of physical exercise on Sestrin1 and 2 accumulations in the skeletal muscle of mice. Crisol BM, et al. Life Sci, 2018 Feb 1. PMID 29273527
  3. The Sertoli cell expressed gene secernin-1 (Scrn1) is dispensable for male fertility in the mouse. Houston BJ, et al. Dev Dyn, 2021 Jul. PMID 33442887, Free PMC Article
  4. Purification and identification of secernin, a novel cytosolic protein that regulates exocytosis in mast cells. Way G, et al. Mol Biol Cell, 2002 Sep. PMID 12221138, Free PMC Article
  5. New candidate genes identified for controlling mouse gonadal sex determination and the early stages of granulosa and Sertoli cell differentiation. Bouma GJ, et al. Biol Reprod, 2010 Feb. PMID 19864314, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Axonal Regeneration Mediated by a Novel Axonal Guidance Pair, Galectin-1 and Secernin-1.
    Title: Axonal Regeneration Mediated by a Novel Axonal Guidance Pair, Galectin-1 and Secernin-1.
  2. The Sertoli cell expressed gene secernin-1 (Scrn1) is dispensable for male fertility in the mouse.
    Title: The Sertoli cell expressed gene secernin-1 (Scrn1) is dispensable for male fertility in the mouse.
  3. While acute aerobic exercise increased Sesn1 accumulation and induced a discrete augment of Sesn2 protein content and AMPK threonine phosphorylation, chronic exercise reduced the basal levels of Sesn1 and Sesn2 as well as of AMPK threonine phosphorylation in the quadriceps muscles of C57BL/6J mice.
    Title: The role of physical exercise on Sestrin1 and 2 accumulations in the skeletal muscle of mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0193

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type exopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables dipeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic vesicle cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
secernin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417702.1 → NP_001404631.1  secernin-1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC084800, AC087841
    UniProtKB/Swiss-Prot
    Q3UKR2, Q8CCL3, Q9CZC8

  2. NM_001417703.1 → NP_001404632.1  secernin-1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC084800, AC087841
    UniProtKB/Swiss-Prot
    Q3UKR2, Q8CCL3, Q9CZC8

  3. NM_001417704.1 → NP_001404633.1  secernin-1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC084800, AC087841
    UniProtKB/Swiss-Prot
    Q3UKR2, Q8CCL3, Q9CZC8

  4. NM_001417705.1 → NP_001404634.1  secernin-1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC087841

  5. NM_001417706.1 → NP_001404635.1  secernin-1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC087841
    Related
    ENSMUSP00000145469.2, ENSMUST00000203800.2

  6. NM_027268.3 → NP_081544.1  secernin-1 isoform a

    See identical proteins and their annotated locations for NP_081544.1

    Status: VALIDATED

    Source sequence(s)
    AC084800, AC087841
    Consensus CDS
    CCDS20156.1
    UniProtKB/Swiss-Prot
    Q3UKR2, Q8CCL3, Q9CZC8
    Related
    ENSMUSP00000019268.5, ENSMUST00000019268.11
    Conserved Domains (1) summary
    cl00467
    Location:18 → 227
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    54451813..54543332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZC8.1 GenPept UniProtKB/Swiss-Prot:Q9CZC8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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