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Trmt10b tRNA methyltransferase 10B [ Mus musculus (house mouse) ]

Gene ID: 69934, updated on 5-Mar-2024

Summary

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Official Symbol
Trmt10bprovided by MGI
Official Full Name
tRNA methyltransferase 10Bprovided by MGI
Primary source
MGI:MGI:1917184
See related
Ensembl:ENSMUSG00000035601 AllianceGenome:MGI:1917184
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rnmtd3; Rg9mtd3; 2610042J10Rik
Summary
Predicted to enable tRNA (guanine-N1-)-methyltransferase activity and tRNA binding activity. Predicted to be involved in tRNA N1-guanine methylation. Predicted to act upstream of or within methylation. Predicted to be located in cytosol. Predicted to be active in nucleoplasm. Orthologous to human TRMT10B (tRNA methyltransferase 10B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 4.1), CNS E11.5 (RPKM 4.0) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 B1; 4 23.83 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (45297158..45316181)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (45297068..45316134)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10091 Neighboring gene translocase of outer mitochondrial membrane 5 Neighboring gene FERM and PDZ domain containing 1 Neighboring gene FERM and PDZ domain containing 1, opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:45309913-45310096 Neighboring gene exosome component 3 Neighboring gene predicted gene, 31017

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (guanosine(9)-N1)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein insertion into mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA N1-guanine methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of TIM22 mitochondrial import inner membrane insertion complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tRNA methyltransferase 10 homolog B
Names
RNA (guanine-9-) methyltransferase domain containing 3
RNA (guanine-9-)-methyltransferase domain-containing protein 3
tRNA (guanine(9)-N(1))-methyltransferase TRMT10B
NP_001406121.1
NP_001406122.1
NP_001406123.1
NP_001406124.1
NP_081542.2
XP_006538308.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419192.1 → NP_001406121.1  tRNA methyltransferase 10 homolog B isoform a

    Status: VALIDATED

    Source sequence(s)
    AL772285
    UniProtKB/Swiss-Prot
    A2AKB5, A2AKB6, Q8VCR1, Q9D075

  2. NM_001419193.1 → NP_001406122.1  tRNA methyltransferase 10 homolog B isoform a

    Status: VALIDATED

    Source sequence(s)
    AL772285
    UniProtKB/Swiss-Prot
    A2AKB5, A2AKB6, Q8VCR1, Q9D075

  3. NM_001419194.1 → NP_001406123.1  tRNA methyltransferase 10 homolog B isoform a

    Status: VALIDATED

    Source sequence(s)
    AL772285
    UniProtKB/Swiss-Prot
    A2AKB5, A2AKB6, Q8VCR1, Q9D075

  4. NM_001419195.1 → NP_001406124.1  tRNA methyltransferase 10 homolog B isoform b

    Status: VALIDATED

    Source sequence(s)
    AL772285
    UniProtKB/TrEMBL
    Z4YKN9
    Related
    ENSMUSP00000103429.2, ENSMUST00000107800.3

  5. NM_027266.5 → NP_081542.2  tRNA methyltransferase 10 homolog B isoform a

    See identical proteins and their annotated locations for NP_081542.2

    Status: VALIDATED

    Source sequence(s)
    AL772285
    Consensus CDS
    CCDS18135.1
    UniProtKB/Swiss-Prot
    A2AKB5, A2AKB6, Q8VCR1, Q9D075
    Related
    ENSMUSP00000041052.3, ENSMUST00000044673.9
    Conserved Domains (1) summary
    cd18100
    Location:126 → 308
    Trm10euk_B; eukaryotic tRNA m1G9 methyltransferase Trm10 homolog B

RNA

  1. NR_185032.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772285

  2. NR_185033.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772285

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    45297158..45316181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538245.3 → XP_006538308.1  tRNA methyltransferase 10 homolog B isoform X2

    Conserved Domains (1) summary
    cd18100
    Location:63 → 245
    Trm10euk_B; eukaryotic tRNA m1G9 methyltransferase Trm10 homolog B

RNA

  1. XR_004941955.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D075.2 GenPept UniProtKB/Swiss-Prot:Q9D075

Gene LinkOut

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