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Zfp715 zinc finger protein 715 [ Mus musculus (house mouse) ]

Gene ID: 69930, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp715provided by MGI
Official Full Name
zinc finger protein 715provided by MGI
Primary source
MGI:MGI:1917180
See related
Ensembl:ENSMUSG00000012640 AllianceGenome:MGI:1917180
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mszf15; 2610041B18Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; intermediate filament cytoskeleton; and nucleoplasm. Is expressed in bladder; female associated reproductive structure; ovary; ureter; and urethra of female. Orthologous to human ZNF175 (zinc finger protein 175). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
7 B3; 7 28.25 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (42945946..42962724, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (43296522..43313300, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18760 Neighboring gene expressed sequence EU599041 Neighboring gene STARR-seq mESC enhancer starr_18761 Neighboring gene STARR-seq mESC enhancer starr_18763 Neighboring gene predicted gene, 35588 Neighboring gene STARR-positive B cell enhancer ABC_E4922 Neighboring gene STARR-seq mESC enhancer starr_18769 Neighboring gene STARR-seq mESC enhancer starr_18772 Neighboring gene sialic acid binding Ig-like lectin F Neighboring gene STARR-positive B cell enhancer mm9_chr7:50633698-50633999 Neighboring gene sialic acid binding Ig-like lectin G

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
  2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 715

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357811.1 → NP_001344740.1  zinc finger protein 715

    Status: VALIDATED

    Source sequence(s)
    AC123045, AC149091
    Consensus CDS
    CCDS39928.1
    UniProtKB/TrEMBL
    G3X9T1
    Conserved Domains (3) summary
    smart00349
    Location:48 → 105
    KRAB; krueppel associated box
    COG5048
    Location:410 → 849
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:442 → 462
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001357812.1 → NP_001344741.1  zinc finger protein 715

    Status: VALIDATED

    Source sequence(s)
    AC123045, AC149091
    Consensus CDS
    CCDS39928.1
    UniProtKB/TrEMBL
    G3X9T1
    Conserved Domains (3) summary
    smart00349
    Location:48 → 105
    KRAB; krueppel associated box
    COG5048
    Location:410 → 849
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:442 → 462
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_027264.4 → NP_081540.3  zinc finger protein 715

    See identical proteins and their annotated locations for NP_081540.3

    Status: VALIDATED

    Source sequence(s)
    AC123045, AC149091
    Consensus CDS
    CCDS39928.1
    UniProtKB/TrEMBL
    G3X9T1
    Related
    ENSMUSP00000103620.3, ENSMUST00000107986.9
    Conserved Domains (3) summary
    smart00349
    Location:48 → 105
    KRAB; krueppel associated box
    COG5048
    Location:410 → 849
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:442 → 462
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    42945946..42962724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242977.2 → XP_030098837.1  zinc finger protein 715 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:378 → 817
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:410 → 430
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:48 → 87
    KRAB; KRAB box

  2. XM_030242976.2 → XP_030098836.1  zinc finger protein 715 isoform X1

    UniProtKB/TrEMBL
    G3X9T1
    Conserved Domains (3) summary
    smart00349
    Location:48 → 105
    KRAB; krueppel associated box
    COG5048
    Location:410 → 849
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:442 → 462
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_036153428.1 → XP_036009321.1  zinc finger protein 715 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:378 → 817
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:410 → 430
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:48 → 87
    KRAB; KRAB box

  4. XM_006541185.5 → XP_006541248.1  zinc finger protein 715 isoform X1

    See identical proteins and their annotated locations for XP_006541248.1

    UniProtKB/TrEMBL
    G3X9T1
    Conserved Domains (3) summary
    smart00349
    Location:48 → 105
    KRAB; krueppel associated box
    COG5048
    Location:410 → 849
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:442 → 462
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_006541183.1 → XP_006541246.1  zinc finger protein 715 isoform X1

    See identical proteins and their annotated locations for XP_006541246.1

    UniProtKB/TrEMBL
    G3X9T1
    Related
    ENSMUSP00000040282.8, ENSMUST00000048015.14
    Conserved Domains (3) summary
    smart00349
    Location:48 → 105
    KRAB; krueppel associated box
    COG5048
    Location:410 → 849
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:442 → 462
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_006541182.1 → XP_006541245.1  zinc finger protein 715 isoform X1

    See identical proteins and their annotated locations for XP_006541245.1

    UniProtKB/TrEMBL
    G3X9T1
    Conserved Domains (3) summary
    smart00349
    Location:48 → 105
    KRAB; krueppel associated box
    COG5048
    Location:410 → 849
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:442 → 462
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. XM_036153427.1 → XP_036009320.1  zinc finger protein 715 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:378 → 817
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:410 → 430
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:48 → 87
    KRAB; KRAB box
Nucleotide Protein Strain
Heading Accession and Version

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