U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Agk acylglycerol kinase [ Mus musculus (house mouse) ]

Gene ID: 69923, updated on 19-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Agkprovided by MGI
Official Full Name
acylglycerol kinaseprovided by MGI
Primary source
MGI:MGI:1917173
See related
Ensembl:ENSMUSG00000029916 AllianceGenome:MGI:1917173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mulk; 2610037M15Rik; 6720408I04Rik
Summary
Enables acylglycerol kinase activity; ceramide kinase activity; and diacylglycerol kinase activity. Acts upstream of or within ceramide biosynthetic process and lipid phosphorylation. Located in membrane. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Sengers syndrome and cataract 38. Orthologous to human AGK (acylglycerol kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 7.1), CNS E14 (RPKM 4.0) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Agk in Genome Data Viewer
Location:
6 B1; 6 18.82 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (40302010..40378723)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (40325076..40397570)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15673 Neighboring gene aldolase A, fructose-bisphosphate pseudogene Neighboring gene transmembrane protein 178B Neighboring gene STARR-seq mESC enhancer starr_15674 Neighboring gene STARR-seq mESC enhancer starr_15675 Neighboring gene STARR-seq mESC enhancer starr_15676 Neighboring gene STARR-seq mESC enhancer starr_15678 Neighboring gene STARR-seq mESC enhancer starr_15681 Neighboring gene STARR-seq mESC enhancer starr_15684 Neighboring gene DENN domain containing 11 Neighboring gene STARR-seq mESC enhancer starr_15685 Neighboring gene WEE1 homolog 2 (S. pombe) Neighboring gene single-stranded DNA binding protein 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The role of AGK in thrombocytopoiesis and possible therapeutic strategies. Jiang H, et al. Blood, 2020 Jul 2. PMID 32202634
  2. Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8(+) T Cells. Hu Z, et al. Cell Metab, 2019 Aug 6. PMID 31204281
  3. MuLK, a eukaryotic multi-substrate lipid kinase. Waggoner DW, et al. J Biol Chem, 2004 Sep 10. PMID 15252046
  4. Acylglycerol kinase promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1 transcription factor. Wang X, et al. Mol Cancer, 2014 May 8. PMID 24886245, Free PMC Article
  5. Further characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies. Van Overloop H, et al. J Lipid Res, 2006 Feb. PMID 16269826

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of AGK in thrombocytopoiesis and possible therapeutic strategies.
    Title: The role of AGK in thrombocytopoiesis and possible therapeutic strategies.
  2. AGK promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1.
    Title: Acylglycerol kinase promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1 transcription factor.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent diacylglycerol kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP-dependent diacylglycerol kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables acylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acylglycerol kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acylglycerol kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables ceramide kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ceramide kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dihydroceramide kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables lipid kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ceramide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein insertion into mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of TIM22 mitochondrial import inner membrane insertion complex ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
acylglycerol kinase, mitochondrial
Names
multi-substrate lipid kinase
multiple substrate lipid kinase
NP_076027.1
XP_006506634.1
XP_011239760.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023538.2 → NP_076027.1  acylglycerol kinase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_076027.1

    Status: VALIDATED

    Source sequence(s)
    AC153728
    Consensus CDS
    CCDS20027.1
    UniProtKB/Swiss-Prot
    Q9D087, Q9ESW4
    Related
    ENSMUSP00000031977.9, ENSMUST00000031977.12
    Conserved Domains (1) summary
    pfam00781
    Location:62 → 195
    DAGK_cat; Diacylglycerol kinase catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    40302010..40378723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241458.3 → XP_011239760.1  acylglycerol kinase, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam00781
    Location:62 → 182
    DAGK_cat; Diacylglycerol kinase catalytic domain

  2. XM_006506571.4 → XP_006506634.1  acylglycerol kinase, mitochondrial isoform X2

    Conserved Domains (1) summary
    pfam00781
    Location:1 → 102
    DAGK_cat; Diacylglycerol kinase catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ESW4.1 GenPept UniProtKB/Swiss-Prot:Q9ESW4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous