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Vrk2 vaccinia related kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 69922, updated on 5-Mar-2024

Summary

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Official Symbol
Vrk2provided by MGI
Official Full Name
vaccinia related kinase 2provided by MGI
Primary source
MGI:MGI:1917172
See related
Ensembl:ENSMUSG00000064090 AllianceGenome:MGI:1917172
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810003O05Rik
Summary
Enables protein serine/threonine kinase activity. Acts upstream of or within protein autophosphorylation. Located in endoplasmic reticulum; membrane; and nuclear envelope. Is expressed in several structures, including cerebral cortex; dorsal mesogastrium; gonad; hemolymphoid system; and yolk sac. Orthologous to human VRK2 (VRK serine/threonine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 6.6), liver E14.5 (RPKM 4.9) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A3.3; 11 15.94 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (26421398..26544006, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (26471398..26594012, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28964 Neighboring gene predicted gene, 22868 Neighboring gene STARR-seq mESC enhancer starr_28965 Neighboring gene STARR-seq mESC enhancer starr_28966 Neighboring gene STARR-positive B cell enhancer mm9_chr11:26287122-26287423 Neighboring gene transmembrane protein 85 pseudogene Neighboring gene Fanconi anemia, complementation group L Neighboring gene VISTA enhancer mm57 Neighboring gene STARR-positive B cell enhancer ABC_E9820 Neighboring gene STARR-positive B cell enhancer ABC_E9821 Neighboring gene STARR-positive B cell enhancer ABC_E905 Neighboring gene STARR-seq mESC enhancer starr_28968 Neighboring gene peptidylprolyl isomerase A pseudogene 11_266.1 Neighboring gene STARR-seq mESC enhancer starr_28969 Neighboring gene VISTA enhancer mm1555 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. VRK2 is involved in the innate antiviral response by promoting mitostress-induced mtDNA release. He WR, et al. Cell Mol Immunol, 2021 May. PMID 33785841, Free PMC Article
  2. Novel alternatively-spliced exons of the VRK2 gene in mouse brain and microglial cells. Almarzooq S, et al. Mol Biol Rep, 2020 Jul. PMID 32583282, Free PMC Article
  3. Vaccinia-related kinase 2 plays a critical role in microglia-mediated synapse elimination during neurodevelopment. Lee J, et al. Glia, 2019 Sep. PMID 31050055
  4. VRK2 activates TNFα/NF-κB signaling by phosphorylating IKKβ in pancreatic cancer. Chen J, et al. Int J Biol Sci, 2022. PMID 35173553, Free PMC Article
  5. HNRNP Q suppresses polyglutamine huntingtin aggregation by post-transcriptional regulation of vaccinia-related kinase 2. Ryu HG, et al. J Neurochem, 2019 May. PMID 30488434

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice.
    Title: Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice.
  2. VRK2 activates TNFalpha/NF-kappaB signaling by phosphorylating IKKbeta in pancreatic cancer.
    Title: VRK2 activates TNFα/NF-κB signaling by phosphorylating IKKβ in pancreatic cancer.
  3. VRK2 is involved in the innate antiviral response by promoting mitostress-induced mtDNA release.
    Title: VRK2 is involved in the innate antiviral response by promoting mitostress-induced mtDNA release.
  4. Novel alternatively-spliced exons of the VRK2 gene in mouse brain and microglial cells.
    Title: Novel alternatively-spliced exons of the VRK2 gene in mouse brain and microglial cells.
  5. these results provide new insights into how neuronal HNRNP Q decreases VRK2 mRNA stability and contributes to the prevention of Huntington's disease
    Title: HNRNP Q suppresses polyglutamine huntingtin aggregation by post-transcriptional regulation of vaccinia-related kinase 2.
  6. In VRK2-deficient mice (VRK2(KO)), reduced numbers of presynaptic puncta within microglia were observed. Moreover, the numbers of presynaptic puncta and synapses were abnormally increased in VRK2(KO) mice by the second postnatal week. These differences did not persist into adulthood. Adult VRK2(KO) mice showed behavioral defects in social behaviors, contextual fear memory, and spatial memory.
    Title: Vaccinia-related kinase 2 plays a critical role in microglia-mediated synapse elimination during neurodevelopment.
  7. VRK genes play a role during embryonic development of hematopoiesis
    Title: Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase VRK2
Names
vaccinia virus BIR kinase related kinase 2
NP_001239376.1
NP_081536.2
XP_006514864.1
XP_011242050.1
XP_030102151.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252447.1 → NP_001239376.1  serine/threonine-protein kinase VRK2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment in the C-terminal region, compared to isoform 1.
    Source sequence(s)
    AC083815, AL929272
    UniProtKB/Swiss-Prot
    Q8BN21
    Conserved Domains (2) summary
    pfam00069
    Location:29 → 292
    Pkinase; Protein kinase domain
    cl21453
    Location:16 → 314
    PKc_like; Protein Kinases, catalytic domain

  2. NM_027260.3 → NP_081536.2  serine/threonine-protein kinase VRK2 isoform 1

    See identical proteins and their annotated locations for NP_081536.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF513620, BB852723, BE984366
    Consensus CDS
    CCDS24486.1
    UniProtKB/Swiss-Prot
    Q3U415, Q5F1Z5, Q5SP88, Q8BN21, Q8BPU8, Q8CJ46, Q91WS1, Q9CZF9
    Related
    ENSMUSP00000077471.7, ENSMUST00000078362.13
    Conserved Domains (1) summary
    cl21453
    Location:16 → 314
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    26421398..26544006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514801.5 → XP_006514864.1  serine/threonine-protein kinase VRK2 isoform X1

    See identical proteins and their annotated locations for XP_006514864.1

    UniProtKB/Swiss-Prot
    Q3U415, Q5F1Z5, Q5SP88, Q8BN21, Q8BPU8, Q8CJ46, Q91WS1, Q9CZF9
    Related
    ENSMUSP00000105130.2, ENSMUST00000109504.8
    Conserved Domains (1) summary
    cl21453
    Location:16 → 314
    PKc_like; Protein Kinases, catalytic domain

  2. XM_030246291.1 → XP_030102151.1  serine/threonine-protein kinase VRK2 isoform X2

    Conserved Domains (2) summary
    PTZ00449
    Location:182 → 370
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cl21453
    Location:1 → 196
    PKc_like; Protein Kinases, catalytic domain

  3. XM_011243748.3 → XP_011242050.1  serine/threonine-protein kinase VRK2 isoform X2

    Conserved Domains (2) summary
    PTZ00449
    Location:182 → 370
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cl21453
    Location:1 → 196
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BN21.2 GenPept UniProtKB/Swiss-Prot:Q8BN21

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