Rasip1 Ras interacting protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rasip1provided by MGI
Official Full Name: Ras interacting protein 1provided by MGI
Primary source: MGI:MGI:1917153
See related: Ensembl:ENSMUSG00000044562 AllianceGenome:MGI:1917153
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rain; 1110025D03Rik; 2610025P08Rik
Summary: Predicted to enable protein homodimerization activity and small GTPase binding activity. Involved in regulation of GTPase activity and tube morphogenesis. Predicted to be located in Golgi apparatus and perinuclear region of cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cell-cell junction. Is expressed in several structures, including body cavity or lining; cardiovascular system; extraembryonic component; genitourinary system; and vertebral axis musculature. Orthologous to human RASIP1 (Ras interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 76.5), adrenal adult (RPKM 24.9) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 29.39 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (45276961..45288516)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (45627537..45639092)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rasip1 regulates Cdc42 activity to regulate cell junctions and cytoskeleton organization, which are both activities required for lymphatic lumen maintenance
Title: Rasip1 controls lymphatic vessel lumen maintenance by regulating endothelial cell junctions.
Rasip1 controls different pools of GTPases, which in turn regulates blood vessel tubulogenesis.
Title: Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Nonmuscle Myosin II.
Rasip1 is necessary in growing embryonic blood vessels.
Title: Rasip1 is essential to blood vessel stability and angiogenic blood vessel growth.
we summarize recent developments in understanding the small G protein RAP1 and its effector RASIP1 as critical mediators of endothelial junction stabilization.
Title: Regulation of vascular endothelial junction stability and remodeling through Rap1-Rasip1 signaling.
RASIP1 regulates the integrity of newly formed blood vessels as an effector of EPAC1-RAP1 signaling.
Title: Rasip1 regulates vertebrate vascular endothelial junction stability through Epac1-Rap1 signaling.
Mice lacking Rasip1 fail to form patent lumens in all blood vessels, including the early endocardial tube. Rasipl null angioblasts fail to properly localize the polarity determinant Par3 and display defective cell polarity.
Title: Blood vessel tubulogenesis requires Rasip1 regulation of GTPase signaling.
Rasip1 expression is undetectable in VEGFR2 null embryos, which lack endothelial cells, suggesting that Rasip1 is endothelial specific. siRNA-mediated reduction of Rasip1 severely impairs angiogenesis and motility in endothelial cell cultures
Title: Rasip1 is required for endothelial cell motility, angiogenesis and vessel formation.
Rain is a novel protein that can serve as an effector of endomembrane-localized Ras
Title: Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branching morphogenesis of an epithelial tube	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Rho-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Rho-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of membrane permeability	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of integrin activation	ISO Inferred from Sequence Orthology more info
involved_in regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028544.1 → NP_082820.1 ras-interacting protein 1

See identical proteins and their annotated locations for NP_082820.1

Status: VALIDATED

Source sequence(s)

AK033276, BB646451, BC028483, BU054468, CO039349

Consensus CDS

CCDS21256.1

UniProtKB/Swiss-Prot

E9QLI7, Q3U0S6, Q6GQW4

UniProtKB/TrEMBL

B9EK92

Related

ENSMUSP00000062429.8, ENSMUST00000057927.10

Conserved Domains (2) summary

cd15472
Location:545 → 911

Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1

pfam00788
Location:141 → 252

RA; Ras association (RalGDS/AF-6) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

45276961..45288516

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_027253.3: Suppressed sequence

Description

NM_027253.3: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.