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Zfp219 zinc finger protein 219 [ Mus musculus (house mouse) ]

Gene ID: 69890, updated on 21-Apr-2024

Summary

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Official Symbol
Zfp219provided by MGI
Official Full Name
zinc finger protein 219provided by MGI
Primary source
MGI:MGI:1917140
See related
Ensembl:ENSMUSG00000049295 AllianceGenome:MGI:1917140
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf219; 2010302A17Rik
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of chondrocyte differentiation and positive regulation of transcription by RNA polymerase II. Acts upstream of or within limb bud formation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human ZNF219 (zinc finger protein 219). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 27.5), CNS E11.5 (RPKM 23.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 C2; 14 26.76 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (52243532..52258597, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (52006075..52021140, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene chaperonin containing Tcp1, subunit 6a (zeta) pseudogene Neighboring gene Rho guanine nucleotide exchange factor 40 Neighboring gene predicted gene, 16617 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:52628339-52628522 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:52628697-52628806 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:52639962-52640145 Neighboring gene STARR-seq mESC enhancer starr_36687 Neighboring gene transmembrane protein 253 Neighboring gene olfactory receptor family 5 subfamily AU member 1 Neighboring gene STARR-seq mESC enhancer starr_36689 Neighboring gene STARR-seq mESC enhancer starr_36690 Neighboring gene STARR-seq mESC enhancer starr_36694 Neighboring gene predicted gene, 22354

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Interplay between the Chd4/NuRD Complex and the Transcription Factor Znf219 Controls Cardiac Cell Identity. El Abdellaoui-Soussi F, et al. Int J Mol Sci, 2022 Aug 24. PMID 36076959, Free PMC Article
  2. Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development. Hildebrand JD, et al. Mol Cell Biol, 2002 Aug. PMID 12101226, Free PMC Article
  3. The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9. Takigawa Y, et al. J Cell Sci, 2010 Nov 1. PMID 20940257
  4. The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins. Paces-Fessy M, et al. Biochem J, 2004 Mar 1. PMID 14611647, Free PMC Article
  5. A protein interaction network for pluripotency of embryonic stem cells. Wang J, et al. Nature, 2006 Nov 16. PMID 17093407

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interplay between the Chd4/NuRD Complex and the Transcription Factor Znf219 Controls Cardiac Cell Identity.
    Title: Interplay between the Chd4/NuRD Complex and the Transcription Factor Znf219 Controls Cardiac Cell Identity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in limb bud formation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 219

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253694.1 → NP_001240623.1  zinc finger protein 219 isoform 1

    See identical proteins and their annotated locations for NP_001240623.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same isoform 1.
    Source sequence(s)
    AC157572
    Consensus CDS
    CCDS36916.1
    UniProtKB/Swiss-Prot
    Q6IQX8, Q921W9, Q924S6, Q9CVF3
    Related
    ENSMUSP00000126854.3, ENSMUST00000166169.4
    Conserved Domains (4) summary
    sd00017
    Location:503 → 523
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:503 → 523
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:515 → 537
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:529 → 552
    zf-H2C2_5; C2H2-type zinc-finger domain

  2. NM_001253695.1 → NP_001240624.1  zinc finger protein 219 isoform 1

    See identical proteins and their annotated locations for NP_001240624.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same isoform 1.
    Source sequence(s)
    AA881069, AK008516, AK053445, CJ184433
    Consensus CDS
    CCDS36916.1
    UniProtKB/Swiss-Prot
    Q6IQX8, Q921W9, Q924S6, Q9CVF3
    Related
    ENSMUSP00000154709.2, ENSMUST00000226522.2
    Conserved Domains (4) summary
    sd00017
    Location:503 → 523
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:503 → 523
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:515 → 537
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:529 → 552
    zf-H2C2_5; C2H2-type zinc-finger domain

  3. NM_001253696.1 → NP_001240625.1  zinc finger protein 219 isoform 2

    See identical proteins and their annotated locations for NP_001240625.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC157572
    Consensus CDS
    CCDS88657.1
    UniProtKB/TrEMBL
    Q4VA98
    Related
    ENSMUSP00000153966.2, ENSMUST00000228580.2
    Conserved Domains (4) summary
    sd00017
    Location:458 → 478
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:458 → 478
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:470 → 492
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:484 → 507
    zf-H2C2_5; C2H2-type zinc-finger domain

  4. NM_027248.2 → NP_081524.2  zinc finger protein 219 isoform 1

    See identical proteins and their annotated locations for NP_081524.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1-3 encode the same isoform 1.
    Source sequence(s)
    AB063578, AK008516, AK053445, BQ890732
    Consensus CDS
    CCDS36916.1
    UniProtKB/Swiss-Prot
    Q6IQX8, Q921W9, Q924S6, Q9CVF3
    Related
    ENSMUSP00000068184.8, ENSMUST00000067549.15
    Conserved Domains (4) summary
    sd00017
    Location:503 → 523
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:503 → 523
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:515 → 537
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:529 → 552
    zf-H2C2_5; C2H2-type zinc-finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    52243532..52258597 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316180.1 → XP_017171669.1  zinc finger protein 219 isoform X1

    UniProtKB/Swiss-Prot
    Q6IQX8, Q921W9, Q924S6, Q9CVF3
    Conserved Domains (4) summary
    sd00017
    Location:503 → 523
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:503 → 523
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:515 → 537
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:529 → 552
    zf-H2C2_5; C2H2-type zinc-finger domain

  2. XM_006519504.5 → XP_006519567.1  zinc finger protein 219 isoform X1

    See identical proteins and their annotated locations for XP_006519567.1

    UniProtKB/Swiss-Prot
    Q6IQX8, Q921W9, Q924S6, Q9CVF3
    Conserved Domains (4) summary
    sd00017
    Location:503 → 523
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:503 → 523
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:515 → 537
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:529 → 552
    zf-H2C2_5; C2H2-type zinc-finger domain

  3. XM_006519499.5 → XP_006519562.1  zinc finger protein 219 isoform X1

    See identical proteins and their annotated locations for XP_006519562.1

    UniProtKB/Swiss-Prot
    Q6IQX8, Q921W9, Q924S6, Q9CVF3
    Conserved Domains (4) summary
    sd00017
    Location:503 → 523
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:503 → 523
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:515 → 537
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:529 → 552
    zf-H2C2_5; C2H2-type zinc-finger domain

  4. XM_036158843.1 → XP_036014736.1  zinc finger protein 219 isoform X1

    UniProtKB/Swiss-Prot
    Q6IQX8, Q921W9, Q924S6, Q9CVF3
    Conserved Domains (4) summary
    sd00017
    Location:503 → 523
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:503 → 523
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:515 → 537
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:529 → 552
    zf-H2C2_5; C2H2-type zinc-finger domain

  5. XM_006519503.3 → XP_006519566.1  zinc finger protein 219 isoform X1

    See identical proteins and their annotated locations for XP_006519566.1

    UniProtKB/Swiss-Prot
    Q6IQX8, Q921W9, Q924S6, Q9CVF3
    Conserved Domains (4) summary
    sd00017
    Location:503 → 523
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:503 → 523
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:515 → 537
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:529 → 552
    zf-H2C2_5; C2H2-type zinc-finger domain

  6. XM_036158844.1 → XP_036014737.1  zinc finger protein 219 isoform X1

    UniProtKB/Swiss-Prot
    Q6IQX8, Q921W9, Q924S6, Q9CVF3
    Conserved Domains (4) summary
    sd00017
    Location:503 → 523
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:503 → 523
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:515 → 537
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:529 → 552
    zf-H2C2_5; C2H2-type zinc-finger domain

  7. XM_036158842.1 → XP_036014735.1  zinc finger protein 219 isoform X1

    UniProtKB/Swiss-Prot
    Q6IQX8, Q921W9, Q924S6, Q9CVF3
    Conserved Domains (4) summary
    sd00017
    Location:503 → 523
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:503 → 523
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:515 → 537
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:529 → 552
    zf-H2C2_5; C2H2-type zinc-finger domain

  8. XM_006519506.5 → XP_006519569.1  zinc finger protein 219 isoform X2

    See identical proteins and their annotated locations for XP_006519569.1

    UniProtKB/TrEMBL
    Q4VA98
    Conserved Domains (4) summary
    sd00017
    Location:458 → 478
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:458 → 478
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:470 → 492
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:484 → 507
    zf-H2C2_5; C2H2-type zinc-finger domain

  9. XM_006519505.2 → XP_006519568.1  zinc finger protein 219 isoform X1

    See identical proteins and their annotated locations for XP_006519568.1

    UniProtKB/Swiss-Prot
    Q6IQX8, Q921W9, Q924S6, Q9CVF3
    Conserved Domains (4) summary
    sd00017
    Location:503 → 523
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:503 → 523
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:515 → 537
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:529 → 552
    zf-H2C2_5; C2H2-type zinc-finger domain

  10. XM_011245177.2 → XP_011243479.1  zinc finger protein 219 isoform X1

    See identical proteins and their annotated locations for XP_011243479.1

    UniProtKB/Swiss-Prot
    Q6IQX8, Q921W9, Q924S6, Q9CVF3
    Conserved Domains (4) summary
    sd00017
    Location:503 → 523
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:503 → 523
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:515 → 537
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:529 → 552
    zf-H2C2_5; C2H2-type zinc-finger domain

  11. XM_006519502.4 → XP_006519565.1  zinc finger protein 219 isoform X1

    See identical proteins and their annotated locations for XP_006519565.1

    UniProtKB/Swiss-Prot
    Q6IQX8, Q921W9, Q924S6, Q9CVF3
    Conserved Domains (4) summary
    sd00017
    Location:503 → 523
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:503 → 523
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:515 → 537
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:529 → 552
    zf-H2C2_5; C2H2-type zinc-finger domain

  12. XM_006519501.5 → XP_006519564.1  zinc finger protein 219 isoform X1

    See identical proteins and their annotated locations for XP_006519564.1

    UniProtKB/Swiss-Prot
    Q6IQX8, Q921W9, Q924S6, Q9CVF3
    Conserved Domains (4) summary
    sd00017
    Location:503 → 523
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:503 → 523
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:515 → 537
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:529 → 552
    zf-H2C2_5; C2H2-type zinc-finger domain

  13. XM_006519498.5 → XP_006519561.1  zinc finger protein 219 isoform X1

    See identical proteins and their annotated locations for XP_006519561.1

    UniProtKB/Swiss-Prot
    Q6IQX8, Q921W9, Q924S6, Q9CVF3
    Conserved Domains (4) summary
    sd00017
    Location:503 → 523
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:503 → 523
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:515 → 537
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:529 → 552
    zf-H2C2_5; C2H2-type zinc-finger domain

  14. XM_011245176.4 → XP_011243478.1  zinc finger protein 219 isoform X1

    See identical proteins and their annotated locations for XP_011243478.1

    UniProtKB/Swiss-Prot
    Q6IQX8, Q921W9, Q924S6, Q9CVF3
    Conserved Domains (4) summary
    sd00017
    Location:503 → 523
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:503 → 523
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:515 → 537
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:529 → 552
    zf-H2C2_5; C2H2-type zinc-finger domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IQX8.1 GenPept UniProtKB/Swiss-Prot:Q6IQX8

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