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Ints14 integrator complex subunit 14 [ Mus musculus (house mouse) ]

Gene ID: 69882, updated on 5-Mar-2024

Summary

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Official Symbol
Ints14provided by MGI
Official Full Name
integrator complex subunit 14provided by MGI
Primary source
MGI:MGI:1917132
See related
Ensembl:ENSMUSG00000034263 AllianceGenome:MGI:1917132
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vwa9; 2010321M09Rik
Summary
Predicted to be involved in snRNA 3'-end processing. Predicted to be located in nucleus. Predicted to be part of integrator complex. Is expressed in cerebral cortex ventricular layer and heart ventricle. Orthologous to human INTS14 (integrator complex subunit 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 14.6), limb E14.5 (RPKM 10.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ints14 in Genome Data Viewer
Location:
9 C; 9 35.02 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (64868143..64894260)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (64960832..64986981)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene DENN domain containing 4A Neighboring gene predicted gene, 24347 Neighboring gene solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 Neighboring gene predicted gene, 39361 Neighboring gene STARR-positive B cell enhancer ABC_E1789 Neighboring gene predicted gene, 25640 Neighboring gene 3-hydroxyacyl-CoA dehydratase 3 Neighboring gene predicted gene, 39362

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks. Latos PA, et al. Genes Dev, 2015 Dec 1. PMID 26584622, Free PMC Article
  2. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
  3. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of integrator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
integrator complex subunit 14
Names
UPF0464 protein C15orf44 homolog
von Willebrand factor A domain containing 9
von Willebrand factor A domain-containing protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077631.3 → NP_001071099.1  integrator complex subunit 14 isoform 1

    See identical proteins and their annotated locations for NP_001071099.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC122463
    Consensus CDS
    CCDS40668.1
    UniProtKB/Swiss-Prot
    Q3THM0, Q3V323, Q3V3E8, Q8C072, Q8R3P6
    Related
    ENSMUSP00000127420.2, ENSMUST00000170517.9
    Conserved Domains (2) summary
    pfam13519
    Location:3 → 117
    VWA_2; von Willebrand factor type A domain
    cl17190
    Location:365 → 489
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  2. NM_001416261.1 → NP_001403190.1  integrator complex subunit 14 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122463
    UniProtKB/Swiss-Prot
    Q3THM0, Q3V323, Q3V3E8, Q8C072, Q8R3P6

  3. NM_001416262.1 → NP_001403191.1  integrator complex subunit 14 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122463

  4. NM_001416263.1 → NP_001403192.1  integrator complex subunit 14 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122463

  5. NM_001416264.1 → NP_001403193.1  integrator complex subunit 14 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122463

  6. NM_001416265.1 → NP_001403194.1  integrator complex subunit 14 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC122463

  7. NM_175153.5 → NP_780362.2  integrator complex subunit 14 isoform 1

    See identical proteins and their annotated locations for NP_780362.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC122463
    Consensus CDS
    CCDS40668.1
    UniProtKB/Swiss-Prot
    Q3THM0, Q3V323, Q3V3E8, Q8C072, Q8R3P6
    Related
    ENSMUSP00000049284.6, ENSMUST00000037504.7
    Conserved Domains (2) summary
    pfam13519
    Location:3 → 117
    VWA_2; von Willebrand factor type A domain
    cl17190
    Location:365 → 489
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    64868143..64894260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R3P6.1 GenPept UniProtKB/Swiss-Prot:Q8R3P6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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