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Thap3 THAP domain containing, apoptosis associated protein 3 [ Mus musculus (house mouse) ]

Gene ID: 69876, updated on 5-Mar-2024

Summary

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Official Symbol
Thap3provided by MGI
Official Full Name
THAP domain containing, apoptosis associated protein 3provided by MGI
Primary source
MGI:MGI:1917126
See related
Ensembl:ENSMUSG00000039759 AllianceGenome:MGI:1917126
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010013E08Rik; 2210418H06Rik
Summary
Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Is expressed in bladder; male associated reproductive structure; testis; ureter; and urethra of male. Orthologous to human THAP3 (THAP domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 23.1), adrenal adult (RPKM 20.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 E2; 4 82.8 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (152067095..152073443, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (151982638..151988986, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene calmodulin binding transcription activator 1 Neighboring gene RIKEN cDNA 9230110K08 gene Neighboring gene STARR-positive B cell enhancer ABC_E30 Neighboring gene predicted gene, 42357 Neighboring gene STARR-positive B cell enhancer ABC_E6290 Neighboring gene STARR-positive B cell enhancer ABC_E3557 Neighboring gene DnaJ heat shock protein family (Hsp40) member C11 Neighboring gene kelch-like 21 Neighboring gene PHD finger protein 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Global gene expression analysis of murine limb development. Taher L, et al. PLoS One, 2011. PMID 22174793, Free PMC Article
  2. RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse. Hüttenhofer A, et al. EMBO J, 2001 Jun 1. PMID 11387227, Free PMC Article
  3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
THAP domain-containing protein 3
Names
snoRNA MBI-15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145929.1 → NP_001139401.1  THAP domain-containing protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL611931, BC059091, BY013572
    Consensus CDS
    CCDS51387.1
    UniProtKB/TrEMBL
    A2A8D4
    Related
    ENSMUSP00000101290.3, ENSMUST00000105665.3
    Conserved Domains (1) summary
    pfam05485
    Location:4 → 82
    THAP; THAP domain

  2. NM_175152.4 → NP_780361.2  THAP domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_780361.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC059091, BC094395, BY013572
    Consensus CDS
    CCDS18982.1
    UniProtKB/Swiss-Prot
    Q8BII6, Q8BJ25
    UniProtKB/TrEMBL
    Q52KE1
    Related
    ENSMUSP00000035240.2, ENSMUST00000036680.8
    Conserved Domains (1) summary
    pfam05485
    Location:4 → 82
    THAP; THAP domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    152067095..152073443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BJ25.1 GenPept UniProtKB/Swiss-Prot:Q8BJ25

Gene LinkOut

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