Pcgf1 polycomb group ring finger 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pcgf1provided by MGI
Official Full Name: polycomb group ring finger 1provided by MGI
Primary source: MGI:MGI:1917087
See related: Ensembl:ENSMUSG00000069678 AllianceGenome:MGI:1917087
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nspc1; 2010002K04Rik
Summary: Predicted to enable promoter-specific chromatin binding activity and protein C-terminus binding activity. Predicted to be involved in heterochromatin assembly; histone H2A-K119 monoubiquitination; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of PcG protein complex. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; nervous system; and striated muscle tissue. Orthologous to human PCGF1 (polycomb group ring finger 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E14 (RPKM 15.0), testis adult (RPKM 12.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 C3; 6 35.94 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (83047573..83057836)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (83077552..83080855)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pcgf1 gene disruption reveals primary involvement of epigenetic mechanism in neuronal subtype specification in the enteric nervous system.
Title: Pcgf1 gene disruption reveals primary involvement of epigenetic mechanism in neuronal subtype specification in the enteric nervous system.
[PCGF1 is highly expressed in rectal adenocarcinoma and silencing PCGF1 inhibits proliferation of rectal adenocarcinoma cells in vitro].
Title: [PCGF1 is highly expressed in rectal adenocarcinoma and silencing PCGF1 inhibits proliferation of rectal adenocarcinoma cells in vitro].
Insufficiency of non-canonical PRC1 synergizes with JAK2V617F in the development of myelofibrosis.
Title: Insufficiency of non-canonical PRC1 synergizes with JAK2V617F in the development of myelofibrosis.
Variant PCGF1-PRC1 links PRC2 recruitment with differentiation-associated transcriptional inactivation at target genes.
Title: Variant PCGF1-PRC1 links PRC2 recruitment with differentiation-associated transcriptional inactivation at target genes.
H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos.
Title: H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos.
Pcgf1 positively regulated expression of essential transcription factors involved in ectoderm and mesoderm differentiation, revealing an unexpected function of Pcgf1 in gene activation during ES cell lineage specification.
Title: Loss of Polycomb Group Protein Pcgf1 Severely Compromises Proper Differentiation of Embryonic Stem Cells.
Nspc1 has a positive role in maintaining the pluripotency of P19 cells by directly regulating Oct4.
Title: Nspc1 regulates the key pluripotent Oct4-Nanog-Sox2 axis in P19 embryonal carcinoma cells via directly activating Oct4.
Pcgf1 is an epigenetic regulator of hematopoietic cell differentiation. Simultaneous depletion of Runx1 and Pcgf1 allows sustained self-renewal while blocking differentiation of lineage marker-negative cells in vitro.
Title: Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH99023 (e-PCR)
- UniSTS:90654

AU024121 (e-PCR)
- UniSTS:164327

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of PRC1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PcG protein complex	IDA Inferred from Direct Assay more info	PubMed
part_of PcG protein complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: polycomb group RING finger protein 1

Names: RING finger protein 68; nervous system Polycomb-1; nervous system polycomb 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001403558.1 → NP_001390487.1 polycomb group RING finger protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC104324

UniProtKB/TrEMBL

A0A0R4J141
NM_001403559.1 → NP_001390488.1 polycomb group RING finger protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC104324

UniProtKB/TrEMBL

H3BK85
NM_001403560.1 → NP_001390489.1 polycomb group RING finger protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC104324

UniProtKB/TrEMBL

H3BK85
NM_001403561.1 → NP_001390490.1 polycomb group RING finger protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC104324

UniProtKB/TrEMBL

H3BK85

Related

ENSMUSP00000135291.2, ENSMUST00000177177.8
NM_197992.2 → NP_932109.2 polycomb group RING finger protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC104324

Consensus CDS

CCDS20270.1

UniProtKB/Swiss-Prot

Q8R023

Related

ENSMUSP00000130614.3, ENSMUST00000165164.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

83047573..83057836

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030255588.2 → XP_030111448.1 polycomb group RING finger protein 1 isoform X1

UniProtKB/TrEMBL

H3BK85

Conserved Domains (1) summary

cd17081
Location:83 → 170

RAWUL_PCGF1; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 1 (PCGF1) and similar proteins