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Med6 mediator complex subunit 6 [ Mus musculus (house mouse) ]

Gene ID: 69792, updated on 11-Apr-2024

Summary

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Official Symbol
Med6provided by MGI
Official Full Name
mediator complex subunit 6provided by MGI
Primary source
MGI:MGI:1917042
See related
Ensembl:ENSMUSG00000002679 AllianceGenome:MGI:1917042
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500012F11Rik
Summary
Enables DNA binding activity. Acts upstream of or within stem cell population maintenance. Located in nucleus. Part of mediator complex. Is expressed in brain; genitourinary system; and limb. Orthologous to human MED6 (mediator complex subunit 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 20.3), placenta adult (RPKM 18.1) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 D1; 12 37.8 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (81620331..81641782, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (81573557..81595008, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene synaptojanin 2 binding protein Cox16 readthrough Neighboring gene STARR-seq mESC enhancer starr_32674 Neighboring gene synaptojanin 2 binding protein Neighboring gene a disintegrin and metallopeptidase domain 21 Neighboring gene STARR-positive B cell enhancer ABC_E1443 Neighboring gene STARR-seq mESC enhancer starr_32676 Neighboring gene 40S ribosomal protein S23 pseudogene Neighboring gene STARR-seq mESC enhancer starr_32677 Neighboring gene tetratricopeptide repeat domain 9 Neighboring gene ragulator complex protein LAMTOR2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways. Jiang YW, et al. Proc Natl Acad Sci U S A, 1998 Jul 21. PMID 9671713, Free PMC Article
  2. MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis. Aranda-Orgilles B, et al. Cell Stem Cell, 2016 Dec 1. PMID 27570068, Free PMC Article
  3. PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. Pavri R, et al. Mol Cell, 2005 Apr 1. PMID 15808511
  4. Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network. Tan C, et al. PLoS Genet, 2021 Sep. PMID 34506481, Free PMC Article
  5. Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Malik S, et al. Mol Cell Biol, 2004 Sep. PMID 15340084, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription elongation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of core mediator complex ISO
Inferred from Sequence Orthology
more info
  
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mediator complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mediator of RNA polymerase II transcription subunit 6
Names
mediator of RNA polymerase II transcription, subunit 6 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347384.1 → NP_001334313.1  mediator of RNA polymerase II transcription subunit 6 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC154908, CK620521, DV651747
    Consensus CDS
    CCDS83983.1
    UniProtKB/Swiss-Prot
    Q3TAK5, Q8BTP9, Q921D4
    Related
    ENSMUSP00000125156.2, ENSMUST00000161211.8
    Conserved Domains (1) summary
    pfam04934
    Location:13 → 140
    Med6; MED6 mediator sub complex component

  2. NM_001347385.1 → NP_001334314.1  mediator of RNA polymerase II transcription subunit 6 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus], compared to isoform 1.
    Source sequence(s)
    AC154908, CK620521, DV651747
    Consensus CDS
    CCDS83982.1
    UniProtKB/TrEMBL
    E0CYA6
    Related
    ENSMUSP00000124361.2, ENSMUST00000161598.8

  3. NM_001347386.1 → NP_001334315.1  mediator of RNA polymerase II transcription subunit 6 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in its 5' UTR compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning results in translation initiation at the downstream start codon to encode an isoform (3) that has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC154908, CK620521, DV651747
    Consensus CDS
    CCDS26023.1
    UniProtKB/TrEMBL
    A0A0R4IZX3
    Related
    ENSMUSP00000002756.8, ENSMUST00000002756.14

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    81620331..81641782 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_027213.2: Suppressed sequence

    Description
    NM_027213.2: This RefSeq was removed because the transcript does not extend far enough 5' to include the start codon.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q921D4.2 GenPept UniProtKB/Swiss-Prot:Q921D4

Gene LinkOut

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