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Bdh2 3-hydroxybutyrate dehydrogenase, type 2 [ Mus musculus (house mouse) ]

Gene ID: 69772, updated on 5-Mar-2024

Summary

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Official Symbol
Bdh2provided by MGI
Official Full Name
3-hydroxybutyrate dehydrogenase, type 2provided by MGI
Primary source
MGI:MGI:1917022
See related
Ensembl:ENSMUSG00000028167 AllianceGenome:MGI:1917022
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dhrs6; 1810026B04Rik
Summary
Enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor. Involved in iron ion homeostasis and siderophore biosynthetic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; cranium; ear; genitourinary system; and respiratory system. Orthologous to human BDH2 (3-hydroxybutyrate dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 79.3), liver adult (RPKM 4.6) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Bdh2 in Genome Data Viewer
Location:
3 G3; 3 62.55 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (134986982..135010187)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (135281221..135304426)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09052 Neighboring gene farnesyl diphosphate synthetase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E11219 Neighboring gene STARR-positive B cell enhancer ABC_E8965 Neighboring gene centromere protein E Neighboring gene predicted gene, 46826 Neighboring gene STARR-seq mESC enhancer starr_09056 Neighboring gene solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 Neighboring gene STARR-seq mESC enhancer starr_09057 Neighboring gene STARR-seq mESC enhancer starr_09058 Neighboring gene solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation of mammalian siderophore 2,5-DHBA in the innate immune response to infection. Liu Z, et al. J Exp Med, 2014 Jun 2. PMID 24863067, Free PMC Article
  2. Endogenous siderophore 2,5-dihydroxybenzoic acid deficiency promotes anemia and splenic iron overload in mice. Liu Z, et al. Mol Cell Biol, 2014 Jul. PMID 24777603, Free PMC Article
  3. 3-hydroxy butyrate dehydrogenase 2 deficiency aggravates systemic lupus erythematosus progression in a mouse model by promoting CD40 ligand demethylation. Yang B, et al. Bioengineered, 2022 Feb. PMID 35001849, Free PMC Article
  4. 3-Hydroxybutyrate dehydrogenase-2 and ferritin-H synergistically regulate intracellular iron. Liu Z, et al. FEBS J, 2014 May. PMID 24673886
  5. A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production. Devireddy LR, et al. Cell, 2010 Jun 11. PMID 20550936, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. 3-hydroxy butyrate dehydrogenase 2 deficiency aggravates systemic lupus erythematosus progression in a mouse model by promoting CD40 ligand demethylation.
    Title: 3-hydroxy butyrate dehydrogenase 2 deficiency aggravates systemic lupus erythematosus progression in a mouse model by promoting CD40 ligand demethylation.
  2. 3-hydroxybutyrate dehydrogenase-2 catalyzes a rate-limiting step in the biogenesis of the mammalian siderophore.
    Title: 3-Hydroxybutyrate dehydrogenase-2 and ferritin-H synergistically regulate intracellular iron.
  3. these findings demonstrate a key role for BDH2 in erythropoiesis.
    Title: Endogenous siderophore 2,5-dihydroxybenzoic acid deficiency promotes anemia and splenic iron overload in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-hydroxybutyrate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-hydroxybutyrate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables 4-oxoproline reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_positive_effect intracellular sequestering of iron ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in siderophore biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in siderophore biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dehydrogenase/reductase SDR family member 6
Names
(R)-beta-hydroxybutyrate dehydrogenase
4-oxo-L-proline reductase
R-beta-hydroxybutyrate dehydrogenase
dehydrogenase/reductase (SDR family) member 6
oxidoreductase UCPA
short chain dehydrogenase/reductase family 15C member 1
NP_001165526.1
NP_081484.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172055.1 → NP_001165526.1  dehydrogenase/reductase SDR family member 6 isoform 1

    See identical proteins and their annotated locations for NP_001165526.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC104874
    Consensus CDS
    CCDS51073.1
    UniProtKB/TrEMBL
    G3UWD3
    Related
    ENSMUSP00000112683.3, ENSMUST00000120397.8
    Conserved Domains (2) summary
    cd05368
    Location:15 → 255
    DHRS6_like_SDR_c; human DHRS6-like, classical (c) SDRs
    PRK06138
    Location:12 → 254
    PRK06138; short chain dehydrogenase; Provisional

  2. NM_027208.2 → NP_081484.1  dehydrogenase/reductase SDR family member 6 isoform 2

    See identical proteins and their annotated locations for NP_081484.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC104874
    Consensus CDS
    CCDS17853.1
    UniProtKB/Swiss-Prot
    Q8JZV9
    Related
    ENSMUSP00000029817.8, ENSMUST00000029817.11
    Conserved Domains (2) summary
    cd05368
    Location:5 → 245
    DHRS6_like_SDR_c; human DHRS6-like, classical (c) SDRs
    PRK06138
    Location:2 → 244
    PRK06138; short chain dehydrogenase; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    134986982..135010187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8JZV9.1 GenPept UniProtKB/Swiss-Prot:Q8JZV9

Gene LinkOut

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