Tnfaip8l2 tumor necrosis factor, alpha-induced protein 8-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnfaip8l2provided by MGI
Official Full Name: tumor necrosis factor, alpha-induced protein 8-like 2provided by MGI
Primary source: MGI:MGI:1917019
See related: Ensembl:ENSMUSG00000013707 AllianceGenome:MGI:1917019
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TIPE2; 1810019A08Rik
Summary: Acts upstream of or within negative regulation of T cell activation and negative regulation of inflammatory response. Located in cytoplasm. Orthologous to human TNFAIP8L2 (TNF alpha induced protein 8 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 43.4), thymus adult (RPKM 22.0) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.1; 3 40.74 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (95046832..95051581, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (95139521..95142416, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TIPE2 knockout reduces myocardial cell damage by inhibiting IFN-gamma-mediated ferroptosis.
Title: TIPE2 knockout reduces myocardial cell damage by inhibiting IFN-γ-mediated ferroptosis.
TIPE2 attenuates neuroinflammation and brain injury through Bcl-2/Bax/cleaved caspase-3 apoptotic pathways after intracerebral hemorrhage in mice.
Title: TIPE2 attenuates neuroinflammation and brain injury through Bcl-2/Bax/cleaved caspase-3 apoptotic pathways after intracerebral hemorrhage in mice.
Tumor Necrosis Factor-alpha-Induced Protein 8-Like 2 Ameliorates Cardiac Hypertrophy by Targeting TLR4 in Macrophages.
Title: Tumor Necrosis Factor-α-Induced Protein 8-Like 2 Ameliorates Cardiac Hypertrophy by Targeting TLR4 in Macrophages.
TIPE2 Promotes Tumor Initiation But Inhibits Tumor Progression in Murine Colitis-Associated Colon Cancer.
Title: TIPE2 Promotes Tumor Initiation But Inhibits Tumor Progression in Murine Colitis-Associated Colon Cancer.
Tumor Necrosis Factor-alpha-Induced Protein 8-Like 2 Fosters Tumor-Associated Microbiota to Promote the Development of Colorectal Cancer.
Title: Tumor Necrosis Factor-α-Induced Protein 8-Like 2 Fosters Tumor-Associated Microbiota to Promote the Development of Colorectal Cancer.
TIPE2 is a checkpoint of natural killer cell maturation and antitumor immunity.
Title: TIPE2 is a checkpoint of natural killer cell maturation and antitumor immunity.
TNF-alpha-induced protein 8-like 2 negatively regulates the immune function of dendritic cells by suppressing autophagy via the TAK1/JNK pathway in septic mice.
Title: TNF-α-induced protein 8-like 2 negatively regulates the immune function of dendritic cells by suppressing autophagy via the TAK1/JNK pathway in septic mice.
TIPE2 inhibits PDGF-BB-induced phenotype switching in airway smooth muscle cells through the PI3K/Akt signaling pathway.
Title: TIPE2 inhibits PDGF-BB-induced phenotype switching in airway smooth muscle cells through the PI3K/Akt signaling pathway.
Tumor Necrosis Factor alpha-Induced Protein 8-Like 2 Alleviates Nonalcoholic Fatty Liver Disease Through Suppressing Transforming Growth Factor Beta-Activated Kinase 1 Activation.
Title: Tumor Necrosis Factor α-Induced Protein 8-Like 2 Alleviates Nonalcoholic Fatty Liver Disease Through Suppressing Transforming Growth Factor Beta-Activated Kinase 1 Activation.
Tumor necrosis factor alphainduced protein 8like 2 contributes to penehyclidine hydrochloride pretreatment against lipopolysaccharideinduced acute lung injury in a mouse model.
Title: Tumor necrosis factor α‑induced protein 8‑like 2 contributes to penehyclidine hydrochloride pretreatment against lipopolysaccharide‑induced acute lung injury in a mouse model.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:234754 (e-PCR)
- UniSTS:234754

NoName (e-PCR)
- UniSTS:234756

D18044 (e-PCR)
- UniSTS:124765

AI415311 (e-PCR)
- UniSTS:178867

AW610835 (e-PCR)
- UniSTS:178868

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T cell activation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tumor necrosis factor alpha-induced protein 8-like protein 2

Names: TNF alpha-induced protein 8-like protein 2; TNFAIP8-like protein 2; tumor necrosis factor, alpha-induced protein 8-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027206.3 → NP_081482.1 tumor necrosis factor alpha-induced protein 8-like protein 2

See identical proteins and their annotated locations for NP_081482.1

Status: VALIDATED

Source sequence(s)

AC131769

Consensus CDS

CCDS17603.1

UniProtKB/Swiss-Prot

Q9D8Y7

Related

ENSMUSP00000013851.4, ENSMUST00000013851.4

Conserved Domains (1) summary

pfam05527
Location:25 → 177

DUF758; Domain of unknown function (DUF758)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

95046832..95051581 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006502040.5 → XP_006502103.1 tumor necrosis factor alpha-induced protein 8-like protein 2 isoform X1

See identical proteins and their annotated locations for XP_006502103.1

UniProtKB/Swiss-Prot

Q9D8Y7

Conserved Domains (1) summary

pfam05527
Location:25 → 177

DUF758; Domain of unknown function (DUF758)