Zswim7 zinc finger SWIM-type containing 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zswim7provided by MGI
Official Full Name: zinc finger SWIM-type containing 7provided by MGI
Primary source: MGI:MGI:1916997
See related: Ensembl:ENSMUSG00000014243 AllianceGenome:MGI:1916997
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SWS1; 2410012H22Rik
Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in double-strand break repair via homologous recombination and protein stabilization. Predicted to act upstream of or within DNA recombination and DNA repair. Predicted to be located in nucleus. Predicted to be part of Shu complex. Orthologous to human ZSWIM7 (zinc finger SWIM-type containing 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 30.3), kidney adult (RPKM 11.1) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B2; 11 37.99 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (62158050..62172221, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (62267224..62281395, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex.
Title: Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex.
These results demonstrate an essential role for SWS1-SWSAP1 in meiotic progression and emphasize the complex interplay of factors that ensure recombinase function.
Title: Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (1) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:488807

NoName (e-PCR)
- UniSTS:487912

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA recombination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Shu complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Shu complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger SWIM domain-containing protein 7

Names: SWIM domain-containing and Srs2-interacting protein 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.