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Pold4 polymerase (DNA-directed), delta 4 [ Mus musculus (house mouse) ]

Gene ID: 69745, updated on 11-Apr-2024

Summary

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Official Symbol
Pold4provided by MGI
Official Full Name
polymerase (DNA-directed), delta 4provided by MGI
Primary source
MGI:MGI:1916995
See related
Ensembl:ENSMUSG00000024854 AllianceGenome:MGI:1916995
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p12; Polds; 2410012M21Rik
Summary
Predicted to contribute to DNA-directed DNA polymerase activity. Acts upstream of or within positive regulation of endothelial cell proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; cranium; genitourinary system; liver; and respiratory system. Orthologous to human POLD4 (DNA polymerase delta 4, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 98.4), mammary gland adult (RPKM 59.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Pold4 in Genome Data Viewer
Location:
19 A; 19 3.93 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4281947..4283688)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4231893..4233634)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4257 Neighboring gene RAD9 checkpoint clamp component A Neighboring gene RIKEN cDNA 1500032F14 gene Neighboring gene predicted gene, 30082 Neighboring gene STARR-positive B cell enhancer ABC_E11667 Neighboring gene predicted gene, 45928 Neighboring gene cardiotrophin-like cytokine factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E969 Neighboring gene STARR-positive B cell enhancer ABC_E5676 Neighboring gene microRNA 6985 Neighboring gene slingshot protein phosphatase 3 Neighboring gene ankyrin repeat domain 13 family, member D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pold4 is dispensable for mouse development, DNA replication and DNA repair. Gu X, et al. Gene, 2023 Jan 30. PMID 36356905
  2. Gene expression profile in fibroblast growth factor 2-transformed endothelial cells. Dell'Era P, et al. Oncogene, 2002 Apr 4. PMID 11948428
  3. FGF2-induced upregulation of DNA polymerase-delta p12 subunit in endothelial cells. Dell'Era P, et al. Oncogene, 2005 Feb 3. PMID 15608665
  4. Identification of RNF8 as a ubiquitin ligase involved in targeting the p12 subunit of DNA polymerase δ for degradation in response to DNA damage. Zhang S, et al. J Biol Chem, 2013 Feb 1. PMID 23233665, Free PMC Article
  5. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pold4 is dispensable for mouse development, DNA replication and DNA repair.
    Title: Pold4 is dispensable for mouse development, DNA replication and DNA repair.
  2. The identification of RNF8 allows new insights into the integration of the control of p12 degradation by different DNA damage signaling pathways.
    Title: Identification of RNF8 as a ubiquitin ligase involved in targeting the p12 subunit of DNA polymerase δ for degradation in response to DNA damage.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Readthrough Gm45928

Readthrough gene: Gm45928, Included gene: Clcf1

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA synthesis involved in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated DNA replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of delta DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of delta DNA polymerase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA polymerase delta subunit 4
Names
DNA polymerase delta smallest subunit p12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027196.4 → NP_081472.1  DNA polymerase delta subunit 4

    See identical proteins and their annotated locations for NP_081472.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AC140073, BC028520
    Consensus CDS
    CCDS29424.1
    UniProtKB/Swiss-Prot
    Q9CWP8
    UniProtKB/TrEMBL
    A0A494BBE1, Q547B4
    Related
    ENSMUSP00000025773.4, ENSMUST00000025773.5
    Conserved Domains (1) summary
    pfam04081
    Location:49 → 88
    DNA_pol_delta_4; DNA polymerase delta, subunit 4

RNA

  1. NR_132280.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon and retains a portion of intron in the 5' terminal exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF.
    Source sequence(s)
    AC140073, BC028520, BQ561369
    Related
    ENSMUST00000235306.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    4281947..4283688
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWP8.1 GenPept UniProtKB/Swiss-Prot:Q9CWP8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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