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Casz1 castor zinc finger 1 [ Mus musculus (house mouse) ]

Gene ID: 69743, updated on 21-Apr-2024

Summary

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Official Symbol
Casz1provided by MGI
Official Full Name
castor zinc finger 1provided by MGI
Primary source
MGI:MGI:1196251
See related
Ensembl:ENSMUSG00000028977 AllianceGenome:MGI:1196251
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cst; D4Ertd432e; 2410019P08Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of neuron differentiation and retina morphogenesis in camera-type eye. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; eye; genitourinary system; heart; and nervous system. Used to study chromosome 1p36 deletion syndrome. Orthologous to human CASZ1 (castor zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in small intestine adult (RPKM 25.0), duodenum adult (RPKM 22.7) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 E2; 4 78.87 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (148888823..149039350)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (148804366..148954893)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32897 Neighboring gene predicted gene, 42350 Neighboring gene STARR-seq mESC enhancer starr_12090 Neighboring gene STARR-seq mESC enhancer starr_12091 Neighboring gene VISTA enhancer mm1532 Neighboring gene predicted gene, 42352 Neighboring gene STARR-seq mESC enhancer starr_12094 Neighboring gene STARR-seq mESC enhancer starr_12095 Neighboring gene predicted gene 15969 Neighboring gene predicted gene 13205 Neighboring gene predicted gene 17029 Neighboring gene VISTA enhancer mm1566 Neighboring gene peroxisomal biogenesis factor 14 Neighboring gene predicted gene, 42351

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A Casz1-NuRD complex regulates temporal identity transitions in neural progenitors. Mattar P, et al. Sci Rep, 2021 Feb 16. PMID 33594190, Free PMC Article
  2. Casz1 controls higher-order nuclear organization in rod photoreceptors. Mattar P, et al. Proc Natl Acad Sci U S A, 2018 Aug 21. PMID 30072429, Free PMC Article
  3. Identification of Casz1 as a Regulatory Protein Controlling T Helper Cell Differentiation, Inflammation, and Immunity. Bhaskaran N, et al. Front Immunol, 2018. PMID 29467767, Free PMC Article
  4. Zinc finger transcription factor Casz1 expression is regulated by homeodomain transcription factor Prrxl1 in embryonic spinal dorsal horn late-born excitatory interneurons. Monteiro CB, et al. Eur J Neurosci, 2016 Jun. PMID 26913565
  5. Crystal structure of mouse mu-crystallin complexed with NADPH and the T3 thyroid hormone. Borel F, et al. FEBS J, 2014 Mar. PMID 24467707

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Casz1-NuRD complex regulates temporal identity transitions in neural progenitors.
    Title: A Casz1-NuRD complex regulates temporal identity transitions in neural progenitors.
  2. these data identify Casz1 as a new Th plasticity regulator having important clinical implications for autoimmune inflammation and mucosal immunity.
    Title: Identification of Casz1 as a Regulatory Protein Controlling T Helper Cell Differentiation, Inflammation, and Immunity.
  3. these data support a model in which Casz1 cooperates with polycomb to control rod genome organization, in part by silencing lamin A/C.
    Title: Casz1 controls higher-order nuclear organization in rod photoreceptors.
  4. Study shows that Casz1 lies downstream of Prrxl1 in the differentiation pathway of a large subset of dorsal late-born excitatory neurons and provides a framework for further studies of Casz1 in assembly of the dorsal root ganglion-spinal circuit.
    Title: Zinc finger transcription factor Casz1 expression is regulated by homeodomain transcription factor Prrxl1 in embryonic spinal dorsal horn late-born excitatory interneurons.
  5. Collectively, our proteomic, biochemical, genetic, and structural studies suggest that the physical interaction between TBX20 and CASZ1 is required for cardiac homeostasis, and further, that reduction or loss of this critical interaction leads to dilated cardiomyopathy (DCM)
    Title: Formation of a TBX20-CASZ1 protein complex is protective against dilated cardiomyopathy and critical for cardiac homeostasis.
  6. these studies establish a role for CASZ1 in mammalian cardiomyocyte cell cycle progression in both the first and second heart fields.
    Title: Casz1 is required for cardiomyocyte G1-to-S phase progression during mammalian cardiac development.
  7. Casz1 is expressed from mid/late stages in retinal progenitor cells.
    Title: A conserved regulatory logic controls temporal identity in mouse neural progenitors.
  8. Abnormal expression of cardiac morphogenesis and contraction genes induced by loss of Casz1 contributes to the heart defect.
    Title: Essential role of the zinc finger transcription factor Casz1 for mammalian cardiac morphogenesis and development.
  9. report the expression pattern of a murine Castor related gene (Cst) during embryogenesis [cst]
    Title: Cst, a novel mouse gene related to Drosophila Castor, exhibits dynamic expression patterns during neurogenesis and heart development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC31683

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of amacrine cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of retinal cone cell fate commitment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of radial glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within retinal bipolar neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within retinal rod cell fate commitment IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within retinal rod cell fate commitment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein castor homolog 1
Names
castor homolog 1, zinc finger
castor-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159344.1 → NP_001152816.1  zinc finger protein castor homolog 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL607145, AL611967
    Consensus CDS
    CCDS51379.1
    UniProtKB/Swiss-Prot
    A2A8A1, Q69Z25, Q9CWL2
    UniProtKB/TrEMBL
    B1AS46
    Related
    ENSMUSP00000112978.2, ENSMUST00000122222.8
    Conserved Domains (1) summary
    PHA03247
    Location:799 → 1158
    PHA03247; large tegument protein UL36; Provisional

  2. NM_027195.2 → NP_081471.2  zinc finger protein castor homolog 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC075673, BI738136
    Consensus CDS
    CCDS38973.1
    UniProtKB/Swiss-Prot
    Q9CWL2
    Related
    ENSMUSP00000092035.4, ENSMUST00000094464.10
    Conserved Domains (1) summary
    PHA03247
    Location:799 → 1158
    PHA03247; large tegument protein UL36; Provisional

RNA

  1. NR_161310.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL607145, BC040081

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    148888823..149039350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539158.2 → XP_006539221.1  zinc finger protein castor homolog 1 isoform X2

    See identical proteins and their annotated locations for XP_006539221.1

    UniProtKB/Swiss-Prot
    A2A8A1, Q69Z25, Q9CWL2
    Conserved Domains (1) summary
    PHA03247
    Location:799 → 1158
    PHA03247; large tegument protein UL36; Provisional

  2. XM_006539159.5 → XP_006539222.1  zinc finger protein castor homolog 1 isoform X2

    See identical proteins and their annotated locations for XP_006539222.1

    UniProtKB/Swiss-Prot
    A2A8A1, Q69Z25, Q9CWL2
    Conserved Domains (1) summary
    PHA03247
    Location:799 → 1158
    PHA03247; large tegument protein UL36; Provisional

  3. XM_006539157.5 → XP_006539220.1  zinc finger protein castor homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A8A1, Q69Z25, Q9CWL2
    Conserved Domains (1) summary
    PHA03247
    Location:823 → 1182
    PHA03247; large tegument protein UL36; Provisional

  4. XM_006539160.5 → XP_006539223.1  zinc finger protein castor homolog 1 isoform X3

    UniProtKB/Swiss-Prot
    A2A8A1, Q69Z25, Q9CWL2
    Conserved Domains (1) summary
    PHA03247
    Location:823 → 1182
    PHA03247; large tegument protein UL36; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWL2.3 GenPept UniProtKB/Swiss-Prot:Q9CWL2

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