Ttl tubulin tyrosine ligase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ttlprovided by MGI
Official Full Name: tubulin tyrosine ligaseprovided by MGI
Primary source: MGI:MGI:1916987
See related: Ensembl:ENSMUSG00000027394 AllianceGenome:MGI:1916987
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2410003M22Rik; 2700049H19Rik
Summary: Enables tubulin-tyrosine ligase activity. Acts upstream of or within microtubule cytoskeleton organization and regulation of axon extension. Predicted to be located in spindle microtubule. Is expressed in musculature and nervous system. Orthologous to human TTL (tubulin tyrosine ligase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 12.5), cortex adult (RPKM 10.7) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F1; 2 62.65 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (128907867..128938203)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (129065947..129096283)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tubulin-tyrosine ligase (TTL) is required to increase the levels of tyrosinated alpha-tubulin at the axon injury site and plays an important role in injury signaling.
Title: Tubulin-tyrosine Ligase (TTL)-mediated Increase in Tyrosinated α-Tubulin in Injured Axons Is Required for Retrograde Injury Signaling and Axon Regeneration.
Our results show that MAP1B abd tubulin-tyrosine ligase indeed interact and that the interaction is not affected by MAP1B phosphorylation.
Title: Microtubule-associated protein 1B interaction with tubulin tyrosine ligase contributes to the control of microtubule tyrosination.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

AI848570 (e-PCR)
- UniSTS:178707

D2Mit399 (e-PCR), detects polymorphism
- UniSTS:129300

D2Mit399.1 (e-PCR), detects polymorphism
- UniSTS:129301

D2Mit399.2 (e-PCR), detects polymorphism
- UniSTS:129302

NoName (e-PCR)
- UniSTS:234521

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables tubulin-tyrosine ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin-tyrosine ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables tubulin-tyrosine ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein modification	ISO Inferred from Sequence Orthology more info
involved_in protein modification process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of metaphase plate congression	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in microtubule	IC Inferred by Curator more info	PubMed
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle microtubule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tubulin--tyrosine ligase

NP_081468.1

EC 6.3.2.25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.