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TRGV1 T cell receptor gamma variable 1 (non-functional) [ Homo sapiens (human) ]

Gene ID: 6973, updated on 23-Nov-2023

Summary

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Official Symbol
TRGV1provided by HGNC
Official Full Name
T cell receptor gamma variable 1 (non-functional)provided by HGNC
Primary source
HGNC:HGNC:12284
See related
Ensembl:ENSG00000211701 IMGT/GENE-DB:TRGV1; AllianceGenome:HGNC:12284
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
V1S1P; TCRGV1
Summary
Predicted to be involved in adaptive immune response. Predicted to be part of T cell receptor complex. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
7p14.1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (38367586..38368055, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (38524467..38524936, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (38407187..38407656, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene T cell receptor gamma locus Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25869 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25870 Neighboring gene T cell receptor gamma locus antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25871 Neighboring gene Sharpr-MPRA regulatory region 15414 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25872 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98538 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_98539 and experimental_98540 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98545 Neighboring gene T cell receptor gamma variable 3 Neighboring gene T cell receptor gamma variable 2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98547 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98548 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98550 Neighboring gene amphiphysin Neighboring gene ReSE screen-validated silencer GRCh37_chr7:38473600-38473818 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98556 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98558 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98567 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25873 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98573 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98575/98576 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98581 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98586 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98589 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98595 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98599 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98607 Neighboring gene RNA, 7SL, cytoplasmic 83, pseudogene Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr7:38629347-38629908 Neighboring gene keratin 8 pseudogene 20

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The promoter regions of the T-cell receptor V9 gamma (TRGV9) and V2 delta (TRDV2) genes display short direct repeats but no TATA box. Dariavach P, et al. FEBS Lett, 1989 Oct 9. PMID 2806544
  2. The human T cell receptor gamma genes are transcribed from TATA-less promoters containing a conserved heptamer sequence. Hettmann T, et al. Mol Immunol, 1992 Sep. PMID 1386651
  3. Diversity and rearrangement of the human T cell rearranging gamma genes: nine germ-line variable genes belonging to two subgroups. LeFranc MP, et al. Cell, 1986 Apr 25. PMID 2938743
  4. Variable region genes in the human T-cell rearranging gamma (TRG) locus: V-J junction and homology with the mouse genes. Huck S, et al. EMBO J, 1988 Mar. PMID 2969332, Free PMC Article
  5. The human T-cell receptor gamma (TRG) genes. Lefranc MP, et al. Trends Biochem Sci, 1989 Jun. PMID 2527426

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

General gene information

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Markers

Other Names

  • T cell receptor gamma variable 1 pseudogene
  • T-cell receptor TRG locus TRGV1*01
  • T-cell receptor, gamma, variable region V1 (pseudogene)

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of T cell receptor complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_001336.2 

    Range
    5893..6362
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    38367586..38368055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    38524467..38524936 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0A0MS02.1 GenPept UniProtKB/Swiss-Prot:A0A0A0MS02

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases