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Ipmk inositol polyphosphate multikinase [ Mus musculus (house mouse) ]

Gene ID: 69718, updated on 18-Apr-2024

Summary

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Official Symbol
Ipmkprovided by MGI
Official Full Name
inositol polyphosphate multikinaseprovided by MGI
Primary source
MGI:MGI:1916968
See related
Ensembl:ENSMUSG00000060733 AllianceGenome:MGI:1916968
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Impk; 2410017C19Rik
Summary
Enables inositol tetrakisphosphate 3-kinase activity and inositol-1,4,5-trisphosphate 3-kinase activity. Acts upstream of or within inositol phosphate biosynthetic process and neural tube formation. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including branchial arch; hindlimb ridge; nervous system; retina nuclear layer; and trunk somite. Orthologous to human IPMK (inositol polyphosphate multikinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in small intestine adult (RPKM 30.9), colon adult (RPKM 26.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 B5.3; 10 36.89 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (71183574..71221715)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (71347744..71385885)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L19, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_27109 Neighboring gene CDGSH iron sulfur domain 1 Neighboring gene STARR-seq mESC enhancer starr_27110 Neighboring gene STARR-seq mESC enhancer starr_27111 Neighboring gene STARR-seq mESC enhancer starr_27112 Neighboring gene proteolipid protein 2 pseudogene Neighboring gene predicted gene, 34486

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gut Epithelial Inositol Polyphosphate Multikinase Alleviates Experimental Colitis via Governing Tuft Cell Homeostasis. Park SE, et al. Cell Mol Gastroenterol Hepatol, 2022. PMID 35988719, Free PMC Article
  2. IPMK modulates hepatic glucose production and insulin signaling. Jung IR, et al. J Cell Physiol, 2022 Aug. PMID 35822903
  3. Phytocannabinoid-dependent mTORC1 regulation is dependent upon inositol polyphosphate multikinase activity. Damstra-Oddy JL, et al. Br J Pharmacol, 2021 Mar. PMID 33347604, Free PMC Article
  4. Inositol polyphosphate multikinase in adipocytes is dispensable for regulating energy metabolism and whole body metabolic homeostasis. Lee S, et al. Am J Physiol Endocrinol Metab, 2020 Aug 1. PMID 32634320
  5. Inositol polyphosphate multikinase mediates extinction of fear memory. Park J, et al. Proc Natl Acad Sci U S A, 2019 Feb 12. PMID 30692248, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inositol polyphosphate multikinase modulates free fatty acids-induced insulin resistance in primary mouse hepatocytes.
    Title: Inositol polyphosphate multikinase modulates free fatty acids-induced insulin resistance in primary mouse hepatocytes.
  2. miRNA-Induced Downregulation of IPMK in Macrophages Mediates Lipopolysaccharide-Triggered TLR4 Signaling.
    Title: miRNA-Induced Downregulation of IPMK in Macrophages Mediates Lipopolysaccharide-Triggered TLR4 Signaling.
  3. Gut Epithelial Inositol Polyphosphate Multikinase Alleviates Experimental Colitis via Governing Tuft Cell Homeostasis.
    Title: Gut Epithelial Inositol Polyphosphate Multikinase Alleviates Experimental Colitis via Governing Tuft Cell Homeostasis.
  4. IPMK modulates hepatic glucose production and insulin signaling.
    Title: IPMK modulates hepatic glucose production and insulin signaling.
  5. Phytocannabinoid-dependent mTORC1 regulation is dependent upon inositol polyphosphate multikinase activity.
    Title: Phytocannabinoid-dependent mTORC1 regulation is dependent upon inositol polyphosphate multikinase activity.
  6. Inositol polyphosphate multikinase in adipocytes is dispensable for regulating energy metabolism and whole body metabolic homeostasis.
    Title: Inositol polyphosphate multikinase in adipocytes is dispensable for regulating energy metabolism and whole body metabolic homeostasis.
  7. Deletion of IPMK in cell lines and intact mice virtually abolishes lipophagy, promotes liver damage as well as inflammation, and impairs hepatocyte regeneration.
    Title: IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration.
  8. These results suggest a physiological role for IPMK in regulating expression of Syt2.
    Title: Inositol polyphosphate multikinase deficiency leads to aberrant induction of synaptotagmin-2 in the forebrain.
  9. Study utilized B cell-specific inositol polyphosphate multikinase (IPMK)-deficient mice to investigate the role of higher order inositol phosphates (InsP6) in B cell immunity and showed that IPMK is a regulator of T cell-independent immune responses and that InsP6 confers a mechanism to regulate the activity of Bruton's tyrosine kinase (Btk) in B cell receptor signaling.
    Title: Inositol polyphosphates promote T cell-independent humoral immunity via the regulation of Bruton's tyrosine kinase.
  10. IP5 promotes HIF-1alpha prolyl hydroxylation and pVHL-dependent degradation of HIF-1alpha. IPMK deletion in mouse brain increases HIF-1alpha/VEGF levels and vascularization. This disrupts blood-brain barrier and enhances brain blood vessel permeability. IPMK, via its product IP5, negatively regulates angiogenesis by inhibiting VEGF expression. IP5 acts by enhancing HIF-1alpha hydroxylation and thus pVHL-dependent degra...
    Title: Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables flavonoid binding ISO
Inferred from Sequence Orthology
more info
  
enables inositol tetrakisphosphate 3-kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables inositol tetrakisphosphate 3-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol tetrakisphosphate 5-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol tetrakisphosphate 6-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol tetrakisphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol-1,4,5-trisphosphate 3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol-1,4,5-trisphosphate 3-kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables inositol-1,4,5-trisphosphate 3-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol-1,4,5-trisphosphate 6-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in inositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within inositol phosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inositol trisphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in necroptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neural tube formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inositol polyphosphate multikinase
Names
inositol 1,3,4,6-tetrakisphosphate 5-kinase
NP_001334120.1
NP_081460.1
XP_011241857.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347191.2 → NP_001334120.1  inositol polyphosphate multikinase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is one aa longer than isoform 1.
    Source sequence(s)
    AC156270
    Consensus CDS
    CCDS83711.1
    UniProtKB/TrEMBL
    D3YWA2
    Related
    ENSMUSP00000112568.2, ENSMUST00000121446.2

  2. NM_027184.3 → NP_081460.1  inositol polyphosphate multikinase isoform 1

    See identical proteins and their annotated locations for NP_081460.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (1).
    Source sequence(s)
    AC156270
    Consensus CDS
    CCDS23918.1
    UniProtKB/Swiss-Prot
    Q7TT16, Q8BZ11, Q8BZA8, Q9CWM9
    Related
    ENSMUSP00000078240.7, ENSMUST00000079252.13
    Conserved Domains (1) summary
    pfam03770
    Location:110 → 391
    IPK; Inositol polyphosphate kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    71183574..71221715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243555.2 → XP_011241857.1  inositol polyphosphate multikinase isoform X1

    Conserved Domains (1) summary
    cl12283
    Location:111 → 194
    IPK; Inositol polyphosphate kinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TT16.1 GenPept UniProtKB/Swiss-Prot:Q7TT16

Gene LinkOut

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