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Pin4 peptidyl-prolyl cis/trans isomerase, NIMA-interacting, 4 (parvulin) [ Mus musculus (house mouse) ]

Gene ID: 69713, updated on 5-Mar-2024

Summary

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Official Symbol
Pin4provided by MGI
Official Full Name
peptidyl-prolyl cis/trans isomerase, NIMA-interacting, 4 (parvulin)provided by MGI
Primary source
MGI:MGI:1916963
See related
Ensembl:ENSMUSG00000079480 AllianceGenome:MGI:1916963
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EPVH; Par14; 2410002I22Rik
Summary
Predicted to enable bent DNA binding activity and double-stranded DNA binding activity. Predicted to be involved in rRNA processing. Predicted to be located in several cellular components, including mitochondrial matrix; nuclear lumen; and spindle. Predicted to be part of preribosome. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Orthologous to human PIN4 (peptidylprolyl cis/trans isomerase, NIMA-interacting 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 25.4), CNS E11.5 (RPKM 21.7) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X D; X 45.14 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (101163075..101171276)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (102119469..102127673)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene NHS like 2 Neighboring gene predicted gene, 25828 Neighboring gene STARR-seq mESC enhancer starr_47665 Neighboring gene STARR-seq mESC enhancer starr_47666 Neighboring gene retrotransposon Gag like 5 Neighboring gene STARR-positive B cell enhancer ABC_E5732 Neighboring gene STARR-positive B cell enhancer ABC_E2538 Neighboring gene high mobility group protein B1 pseudogene Neighboring gene excision repair cross-complementing rodent repair deficiency complementation group 6 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The N-terminal basic domain of human parvulin hPar14 is responsible for the entry to the nucleus and high-affinity DNA-binding. Surmacz TA, et al. J Mol Biol, 2002 Aug 9. PMID 12144781
  2. Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions. Zhang J, et al. J Biol Chem, 2013 Jul 12. PMID 23720771, Free PMC Article
  3. Deterministic and stochastic allele specific gene expression in single mouse blastomeres. Tang F, et al. PLoS One, 2011. PMID 21731673, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate the association of Par14 with insulin receptor substrate 1 (IRS-1) in human HepG2 cells overexpressing both as well as endogenously in the mouse liver.
    Title: Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables bent DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in localization ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of preribosome ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peptidyl-prolyl cis-trans isomerase NIMA-interacting 4
Names
PPIase Pin4
parvulin-14
peptidyl-prolyl cis-trans isomerase Pin4
protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)
rotamase Pin4
NP_001352019.1
NP_081457.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365090.2 → NP_001352019.1  peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL807784
    Related
    ENSMUST00000144367.2
    Conserved Domains (1) summary
    cl29122
    Location:4 → 80
    Rotamase_2; PPIC-type PPIASE domain

  2. NM_027181.3 → NP_081457.1  peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 1

    See identical proteins and their annotated locations for NP_081457.1

    Status: VALIDATED

    Source sequence(s)
    AL807784
    Consensus CDS
    CCDS41082.1
    UniProtKB/Swiss-Prot
    Q0VE57, Q9CWW6
    Related
    ENSMUSP00000109257.4, ENSMUST00000113627.4
    Conserved Domains (1) summary
    cl29122
    Location:30 → 131
    Rotamase_2; PPIC-type PPIASE domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    101163075..101171276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWW6.1 GenPept UniProtKB/Swiss-Prot:Q9CWW6

Gene LinkOut

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