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Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 [ Mus musculus (house mouse) ]

Gene ID: 69710, updated on 11-Apr-2024

Summary

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Official Symbol
Arap1provided by MGI
Official Full Name
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1provided by MGI
Primary source
MGI:MGI:1916960
See related
Ensembl:ENSMUSG00000032812 AllianceGenome:MGI:1916960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Centd2; mKIAA0782; 2410002L19Rik
Summary
Predicted to enable GTPase activator activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and type 1 angiotensin receptor binding activity. Predicted to be involved in several processes, including negative regulation of stress fiber assembly; positive regulation of filopodium assembly; and positive regulation of receptor recycling. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in cytoplasmic vesicle; plasma membrane; and trans-Golgi network. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; genitourinary system; and hemolymphoid system gland. Orthologous to human ARAP1 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 27.7), subcutaneous fat pad adult (RPKM 20.3) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Arap1 in Genome Data Viewer
Location:
7 E2; 7 54.56 cM
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100997296..101061793)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101347921..101412586)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:108450776-108450959 Neighboring gene autophagy related 16 like 2 Neighboring gene STARR-seq mESC enhancer starr_19689 Neighboring gene STARR-positive B cell enhancer ABC_E1349 Neighboring gene StAR related lipid transfer domain containing 10 Neighboring gene predicted gene 20476 Neighboring gene STARR-seq mESC enhancer starr_19692 Neighboring gene predicted gene, 35219 Neighboring gene STARR-positive B cell enhancer ABC_E4957 Neighboring gene STARR-positive B cell enhancer ABC_E1740 Neighboring gene phosphodiesterase 2A, cGMP-stimulated Neighboring gene microRNA 139 Neighboring gene STARR-positive B cell enhancer ABC_E6576 Neighboring gene predicted gene, 35363

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pro-fibrotic and apoptotic activities of circARAP1 in myocardial ischemia-reperfusion injury. Li X, et al. Eur J Med Res, 2023 Feb 20. PMID 36803446, Free PMC Article
  2. Arap1 Deficiency Causes Photoreceptor Degeneration in Mice. Moshiri A, et al. Invest Ophthalmol Vis Sci, 2017 Mar 1. PMID 28324111, Free PMC Article
  3. Arap1 loss causes retinal pigment epithelium phagocytic dysfunction and subsequent photoreceptor death. Shao A, et al. Dis Model Mech, 2022 Jul 1. PMID 35758026, Free PMC Article
  4. A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell. Kulzer JR, et al. Am J Hum Genet, 2014 Feb 6. PMID 24439111, Free PMC Article
  5. Angiotensin AT1 receptor-associated protein Arap1 in the kidney vasculature is suppressed by angiotensin II. Doblinger E, et al. Am J Physiol Renal Physiol, 2012 May 15. PMID 22357923

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pro-fibrotic and apoptotic activities of circARAP1 in myocardial ischemia-reperfusion injury.
    Title: Pro-fibrotic and apoptotic activities of circARAP1 in myocardial ischemia-reperfusion injury.
  2. Arap1 loss causes retinal pigment epithelium phagocytic dysfunction and subsequent photoreceptor death.
    Title: Arap1 loss causes retinal pigment epithelium phagocytic dysfunction and subsequent photoreceptor death.
  3. competitive analytical gel-filtration chromatography and isothermal titration calorimetry (ITC) results showed that ARAP1 could compete with Cbl for CIN85 binding, which provides a biochemical basis for the regulatory roles of ARAP1 in the CIN85-mediated EGFR internalizing process.
    Title: Biochemical and Structural Studies of the Interaction between ARAP1 and CIN85.
  4. Quantitative trait loci genes analysis reveals association between T2D risk variants at the ARAP1/STARD10 locus and STARD10 but not ARAP1 expression.
    Title: Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice.
  5. Increased ARAP1 expression might contribute to type 2 diabetes susceptibility at this Genome-wide association studies locus.
    Title: A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell.
  6. Arap1 is highly expressed in the renal vasculature, and its expression is suppressed by angiotensin II.
    Title: Angiotensin AT1 receptor-associated protein Arap1 in the kidney vasculature is suppressed by angiotensin II.
  7. afadin regulates the cyclical activation and inactivation of Rap1, Rac1, and RhoA through SPA-1 and ARAP1.
    Title: Regulation by afadin of cyclical activation and inactivation of Rap1, Rac1, and RhoA small G proteins at leading edges of moving NIH3T3 cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC176140

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables type 1 angiotensin receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of receptor recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
Names
centaurin, delta 2
cnt-d2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040111.2 → NP_001035200.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001035200.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) is the longest transcript and it encodes isoform 3.
    Source sequence(s)
    AC129079
    Consensus CDS
    CCDS40041.1
    UniProtKB/Swiss-Prot
    Q4LDD4
    Related
    ENSMUSP00000102624.3, ENSMUST00000107010.9
    Conserved Domains (11) summary
    cd09490
    Location:6 → 68
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    smart00454
    Location:10 → 65
    SAM; Sterile alpha motif
    cd04385
    Location:959 → 1137
    RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...
    cd13253
    Location:331 → 422
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:438 → 527
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13256
    Location:745 → 851
    PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
    cd13259
    Location:1265 → 1393
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    pfam00169
    Location:330 → 420
    PH; PH domain
    pfam01412
    Location:537 → 653
    ArfGap; Putative GTPase activating protein for Arf
    cl00155
    Location:1174 → 1262
    UBQ; Ubiquitin-like proteins
    cl17171
    Location:864 → 954
    PH-like; Pleckstrin homology-like domain

  2. NM_001040112.2 → NP_001035201.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001035201.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks some 5' coding sequence, compared to variant 3. These differences cause translation initiation at a downstream AUG and an isoform (1) with a shorter N-terminus compared to isoform 3. Variants 1 and 4 encode the same protein.
    Source sequence(s)
    AC129079
    Consensus CDS
    CCDS21510.1
    UniProtKB/Swiss-Prot
    Q4LDD4
    Related
    ENSMUSP00000081957.6, ENSMUST00000084895.12
    Conserved Domains (8) summary
    cd04385
    Location:711 → 889
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:83 → 174
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:190 → 279
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13256
    Location:497 → 603
    PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
    cd13259
    Location:1017 → 1145
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17226
    Location:925 → 1017
    RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)
    cd08837
    Location:289 → 404
    ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins
    cl17171
    Location:616 → 706
    PH-like; Pleckstrin homology-like domain

  3. NM_001407801.1 → NP_001394730.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC129079

  4. NM_001407803.1 → NP_001394732.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC129079
    UniProtKB/Swiss-Prot
    B2RUJ3, Q3UDD2, Q3US99, Q4LDD4, Q58ET6, Q6PEQ9, Q6ZQ48
    Conserved Domains (9) summary
    cd09490
    Location:6 → 68
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    cd04385
    Location:959 → 1137
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:331 → 422
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:438 → 527
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13256
    Location:745 → 851
    PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
    cd13259
    Location:1265 → 1404
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17226
    Location:1173 → 1265
    RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)
    cd08837
    Location:537 → 652
    ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins
    cl17171
    Location:864 → 954
    PH-like; Pleckstrin homology-like domain

  5. NM_027180.4 → NP_081456.2  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_081456.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and lacks some 5' coding sequence, compared to variant 3. These differences cause translation initiation at a downstream AUG and an isoform (1) with a shorter N-terminus compared to isoform 3. Variants 1 and 4 encode the same protein.
    Source sequence(s)
    AC129079
    Consensus CDS
    CCDS21510.1
    UniProtKB/Swiss-Prot
    Q4LDD4
    Conserved Domains (8) summary
    cd04385
    Location:711 → 889
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:83 → 174
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:190 → 279
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13256
    Location:497 → 603
    PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
    cd13259
    Location:1017 → 1145
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17226
    Location:925 → 1017
    RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)
    cd08837
    Location:289 → 404
    ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins
    cl17171
    Location:616 → 706
    PH-like; Pleckstrin homology-like domain

  6. NM_198096.2 → NP_932764.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks some 5' coding sequence, compared to variant 3. These differences cause translation initiation at a downstream AUG and an isoform (2) with a shorter N-terminus compared to isoform 3.
    Source sequence(s)
    AC129079
    Consensus CDS
    CCDS40042.1
    UniProtKB/TrEMBL
    E9PUB0
    Related
    ENSMUSP00000095844.3, ENSMUST00000098243.4
    Conserved Domains (6) summary
    cd04385
    Location:245 → 423
    RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...
    cd13256
    Location:31 → 137
    PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
    cd13259
    Location:551 → 679
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    pfam00169
    Location:32 → 136
    PH; PH domain
    cl00155
    Location:460 → 548
    UBQ; Ubiquitin-like proteins
    cl17171
    Location:150 → 240
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    100997296..101061793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242973.2 → XP_030098833.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X2

    Conserved Domains (8) summary
    cd04385
    Location:716 → 894
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:88 → 179
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:195 → 284
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13256
    Location:502 → 608
    PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
    cd13259
    Location:1022 → 1161
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17226
    Location:930 → 1022
    RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)
    cd08837
    Location:294 → 409
    ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins
    cl17171
    Location:621 → 711
    PH-like; Pleckstrin homology-like domain

  2. XM_030242974.2 → XP_030098834.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X5

    Conserved Domains (8) summary
    cd04385
    Location:643 → 821
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:15 → 106
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:122 → 211
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13256
    Location:429 → 535
    PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
    cd13259
    Location:949 → 1088
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17226
    Location:857 → 949
    RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)
    cd08837
    Location:221 → 336
    ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins
    cl17171
    Location:548 → 638
    PH-like; Pleckstrin homology-like domain

  3. XM_006508188.5 → XP_006508251.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006508251.1

    UniProtKB/Swiss-Prot
    B2RUJ3, Q3UDD2, Q3US99, Q4LDD4, Q58ET6, Q6PEQ9, Q6ZQ48
    Related
    ENSMUSP00000081958.4, ENSMUST00000084896.10
    Conserved Domains (9) summary
    cd09490
    Location:6 → 68
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    cd04385
    Location:959 → 1137
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:331 → 422
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:438 → 527
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13256
    Location:745 → 851
    PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
    cd13259
    Location:1265 → 1404
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17226
    Location:1173 → 1265
    RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)
    cd08837
    Location:537 → 652
    ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins
    cl17171
    Location:864 → 954
    PH-like; Pleckstrin homology-like domain

  4. XM_006508187.3 → XP_006508250.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006508250.1

    UniProtKB/Swiss-Prot
    B2RUJ3, Q3UDD2, Q3US99, Q4LDD4, Q58ET6, Q6PEQ9, Q6ZQ48
    Conserved Domains (9) summary
    cd09490
    Location:6 → 68
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    cd04385
    Location:959 → 1137
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:331 → 422
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:438 → 527
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13256
    Location:745 → 851
    PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
    cd13259
    Location:1265 → 1404
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17226
    Location:1173 → 1265
    RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)
    cd08837
    Location:537 → 652
    ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins
    cl17171
    Location:864 → 954
    PH-like; Pleckstrin homology-like domain

  5. XM_011241897.4 → XP_011240199.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011240199.1

    UniProtKB/Swiss-Prot
    B2RUJ3, Q3UDD2, Q3US99, Q4LDD4, Q58ET6, Q6PEQ9, Q6ZQ48
    Conserved Domains (9) summary
    cd09490
    Location:6 → 68
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    cd04385
    Location:959 → 1137
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:331 → 422
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:438 → 527
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13256
    Location:745 → 851
    PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
    cd13259
    Location:1265 → 1404
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17226
    Location:1173 → 1265
    RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)
    cd08837
    Location:537 → 652
    ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins
    cl17171
    Location:864 → 954
    PH-like; Pleckstrin homology-like domain

  6. XM_036153422.1 → XP_036009315.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X4

    Conserved Domains (8) summary
    cd04385
    Location:711 → 889
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:83 → 174
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:190 → 279
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13256
    Location:497 → 603
    PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
    cd13259
    Location:1017 → 1145
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17226
    Location:925 → 1017
    RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)
    cd08837
    Location:289 → 404
    ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins
    cl17171
    Location:616 → 706
    PH-like; Pleckstrin homology-like domain

  7. XM_006508190.3 → XP_006508253.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006508253.1

    Conserved Domains (8) summary
    cd04385
    Location:711 → 889
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:83 → 174
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:190 → 279
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13256
    Location:497 → 603
    PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
    cd13259
    Location:1017 → 1156
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17226
    Location:925 → 1017
    RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)
    cd08837
    Location:289 → 404
    ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins
    cl17171
    Location:616 → 706
    PH-like; Pleckstrin homology-like domain

  8. XM_006508193.3 → XP_006508256.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X5

    Conserved Domains (8) summary
    cd04385
    Location:643 → 821
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:15 → 106
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:122 → 211
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13256
    Location:429 → 535
    PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
    cd13259
    Location:949 → 1088
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17226
    Location:857 → 949
    RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)
    cd08837
    Location:221 → 336
    ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins
    cl17171
    Location:548 → 638
    PH-like; Pleckstrin homology-like domain

  9. XM_006508192.3 → XP_006508255.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006508255.1

    Conserved Domains (8) summary
    cd04385
    Location:711 → 889
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:83 → 174
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:190 → 279
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13256
    Location:497 → 603
    PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
    cd13259
    Location:1017 → 1156
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17226
    Location:925 → 1017
    RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)
    cd08837
    Location:289 → 404
    ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins
    cl17171
    Location:616 → 706
    PH-like; Pleckstrin homology-like domain

  10. XM_006508191.5 → XP_006508254.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006508254.1

    Conserved Domains (8) summary
    cd04385
    Location:711 → 889
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:83 → 174
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:190 → 279
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13256
    Location:497 → 603
    PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
    cd13259
    Location:1017 → 1156
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17226
    Location:925 → 1017
    RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)
    cd08837
    Location:289 → 404
    ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins
    cl17171
    Location:616 → 706
    PH-like; Pleckstrin homology-like domain

  11. XM_036153421.1 → XP_036009314.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X3

    Conserved Domains (8) summary
    cd04385
    Location:711 → 889
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:83 → 174
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:190 → 279
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13256
    Location:497 → 603
    PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
    cd13259
    Location:1017 → 1156
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17226
    Location:925 → 1017
    RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)
    cd08837
    Location:289 → 404
    ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins
    cl17171
    Location:616 → 706
    PH-like; Pleckstrin homology-like domain

RNA

  1. XR_003946560.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4LDD4.2 GenPept UniProtKB/Swiss-Prot:Q4LDD4

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