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Tatdn1 TatD DNase domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 69694, updated on 5-Mar-2024

Summary

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Official Symbol
Tatdn1provided by MGI
Official Full Name
TatD DNase domain containing 1provided by MGI
Primary source
MGI:MGI:1916944
See related
Ensembl:ENSMUSG00000050891 AllianceGenome:MGI:1916944
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CDA11; 2310079P03Rik
Summary
Predicted to enable 3'-5'-exodeoxyribonuclease activity. Predicted to be located in nucleoplasm. Orthologous to human TATDN1 (TatD DNase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 4.9), liver E14 (RPKM 4.4) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 D1; 15 25.09 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (58762002..58805605, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (58890153..58933756, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3142 Neighboring gene tRNA methyltransferase 12 Neighboring gene predicted gene, 36509 Neighboring gene ring finger protein 139 Neighboring gene STARR-seq mESC enhancer starr_38762 Neighboring gene STARR-positive B cell enhancer ABC_E8590 Neighboring gene NADH:ubiquinone oxidoreductase subunit B9 Neighboring gene MTSS I-BAR domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E8591 Neighboring gene RIKEN cDNA 4930544F09 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5'-DNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
deoxyribonuclease TATDN1
Names
putative deoxyribonuclease TATDN1
NP_001355357.1
NP_001355557.1
NP_001355558.1
NP_001355559.1
NP_001355560.1
NP_001355561.1
NP_001355562.1
NP_001355563.1
NP_001355564.1
NP_001355565.1
NP_780360.1
XP_006521429.1
XP_006521430.1
XP_006521437.1
XP_030104616.1
XP_030104617.1
XP_030104618.1
XP_030104619.1
XP_030104621.1
XP_036015463.1
XP_036015464.1
XP_036015465.1
XP_036015466.1
XP_036015467.1
XP_036015468.1
XP_036015469.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368428.1 → NP_001355357.1  deoxyribonuclease TATDN1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC158777
    Consensus CDS
    CCDS88768.1
    UniProtKB/Swiss-Prot
    Q6P8M1, Q8BY37
    Related
    ENSMUSP00000154677.2, ENSMUST00000228538.3
    Conserved Domains (1) summary
    cd01310
    Location:6 → 294
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

  2. NM_001368628.1 → NP_001355557.1  deoxyribonuclease TATDN1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158777
    Conserved Domains (1) summary
    cd01310
    Location:1 → 247
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

  3. NM_001368629.1 → NP_001355558.1  deoxyribonuclease TATDN1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC158777
    Conserved Domains (1) summary
    cd01310
    Location:3 → 226
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

  4. NM_001368630.1 → NP_001355559.1  deoxyribonuclease TATDN1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC158777
    Conserved Domains (1) summary
    cd01310
    Location:3 → 226
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

  5. NM_001368631.1 → NP_001355560.1  deoxyribonuclease TATDN1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC158777
    Conserved Domains (1) summary
    cd01310
    Location:3 → 226
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

  6. NM_001368632.1 → NP_001355561.1  deoxyribonuclease TATDN1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC158777
    Conserved Domains (1) summary
    cd01310
    Location:3 → 226
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

  7. NM_001368633.1 → NP_001355562.1  deoxyribonuclease TATDN1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC158777
    Conserved Domains (1) summary
    cd01310
    Location:3 → 226
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

  8. NM_001368634.1 → NP_001355563.1  deoxyribonuclease TATDN1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC158777
    Conserved Domains (1) summary
    cd01310
    Location:6 → 226
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

  9. NM_001368635.1 → NP_001355564.1  deoxyribonuclease TATDN1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC158777
    Conserved Domains (1) summary
    cl00281
    Location:1 → 179
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

  10. NM_001368636.1 → NP_001355565.1  deoxyribonuclease TATDN1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC158777
    Conserved Domains (1) summary
    cl00281
    Location:3 → 158
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

  11. NM_175151.5 → NP_780360.1  deoxyribonuclease TATDN1 isoform 2

    See identical proteins and their annotated locations for NP_780360.1

    Status: VALIDATED

    Source sequence(s)
    AC158777
    Consensus CDS
    CCDS37082.1
    UniProtKB/TrEMBL
    A0A0R4J1E8
    Related
    ENSMUSP00000105783.2, ENSMUST00000110155.3
    Conserved Domains (1) summary
    cd01310
    Location:6 → 263
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    58762002..58805605 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521367.4 → XP_006521430.1  deoxyribonuclease TATDN1 isoform X2

    Conserved Domains (1) summary
    cd01310
    Location:13 → 278
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

  2. XM_036159570.1 → XP_036015463.1  deoxyribonuclease TATDN1 isoform X2

    Conserved Domains (1) summary
    cd01310
    Location:13 → 278
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

  3. XM_036159576.1 → XP_036015469.1  deoxyribonuclease TATDN1 isoform X6

    Conserved Domains (1) summary
    cl00281
    Location:3 → 158
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

  4. XM_030248756.2 → XP_030104616.1  deoxyribonuclease TATDN1 isoform X3

    Conserved Domains (1) summary
    cd01310
    Location:3 → 226
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

  5. XM_030248761.2 → XP_030104621.1  deoxyribonuclease TATDN1 isoform X6

    Conserved Domains (1) summary
    cl00281
    Location:3 → 158
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

  6. XM_030248757.2 → XP_030104617.1  deoxyribonuclease TATDN1 isoform X3

    Conserved Domains (1) summary
    cd01310
    Location:3 → 226
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

  7. XM_030248759.2 → XP_030104619.1  deoxyribonuclease TATDN1 isoform X5

    Conserved Domains (1) summary
    cl00281
    Location:1 → 179
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

  8. XM_036159575.1 → XP_036015468.1  deoxyribonuclease TATDN1 isoform X6

    Conserved Domains (1) summary
    cl00281
    Location:3 → 158
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

  9. XM_036159571.1 → XP_036015464.1  deoxyribonuclease TATDN1 isoform X3

    Conserved Domains (1) summary
    cd01310
    Location:3 → 226
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

  10. XM_036159574.1 → XP_036015467.1  deoxyribonuclease TATDN1 isoform X6

    Conserved Domains (1) summary
    cl00281
    Location:3 → 158
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

  11. XM_036159573.1 → XP_036015466.1  deoxyribonuclease TATDN1 isoform X3

    Conserved Domains (1) summary
    cd01310
    Location:3 → 226
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

  12. XM_006521374.2 → XP_006521437.1  deoxyribonuclease TATDN1 isoform X3

    See identical proteins and their annotated locations for XP_006521437.1

    Conserved Domains (1) summary
    cd01310
    Location:3 → 226
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

  13. XM_036159572.1 → XP_036015465.1  deoxyribonuclease TATDN1 isoform X3

    Conserved Domains (1) summary
    cd01310
    Location:3 → 226
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

  14. XM_030248758.1 → XP_030104618.1  deoxyribonuclease TATDN1 isoform X4

    Conserved Domains (1) summary
    cl00281
    Location:6 → 195
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

  15. XM_006521366.4 → XP_006521429.1  deoxyribonuclease TATDN1 isoform X1

    Conserved Domains (1) summary
    cd01310
    Location:6 → 263
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

RNA

  1. XR_003951437.2 RNA Sequence

  2. XR_004938870.1 RNA Sequence

    Related
    ENSMUST00000227540.2

  3. XR_003951436.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P8M1.1 GenPept UniProtKB/Swiss-Prot:Q6P8M1

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