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Hddc2 HD domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 69692, updated on 11-Apr-2024

Summary

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Official Symbol
Hddc2provided by MGI
Official Full Name
HD domain containing 2provided by MGI
Primary source
MGI:MGI:1916942
See related
Ensembl:ENSMUSG00000000295 AllianceGenome:MGI:1916942
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310057G13Rik
Summary
Predicted to enable 5'-deoxynucleotidase activity. Located in mitochondrion. Is expressed in heart. Orthologous to human HDDC2 (HD domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 2.8), ovary adult (RPKM 2.2) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 A4; 10 17.34 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (31189296..31204200)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (31313330..31328204)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26212 Neighboring gene VISTA enhancer mm762 Neighboring gene spermine synthase pseudogene Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26213 Neighboring gene STARR-positive B cell enhancer ABC_E8329 Neighboring gene tumor protein D52-like 1 Neighboring gene SPT4B, DSIF elongation factor subunit Neighboring gene STARR-seq mESC enhancer starr_26215 Neighboring gene predicted gene, 51764

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of Hey2 transcription factor in the early embryonic ventricles is controlled through a distal enhancer by Tbx20 and Gata transcription factors. Ihara D, et al. Dev Biol, 2020 May 15. PMID 32035085
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC129436, MGC129437

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-deoxynucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
5'-deoxynucleotidase HDDC2
Names
HD domain-containing protein 2
NP_001403988.1
NP_001403989.1
NP_001403990.1
NP_001403991.1
NP_081444.1
XP_030101112.1
XP_036011879.1
XP_036011880.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417059.1 → NP_001403988.1  5'-deoxynucleotidase HDDC2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153969

  2. NM_001417060.1 → NP_001403989.1  5'-deoxynucleotidase HDDC2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC153969

  3. NM_001417061.1 → NP_001403990.1  5'-deoxynucleotidase HDDC2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC153969

  4. NM_001417062.1 → NP_001403991.1  5'-deoxynucleotidase HDDC2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC153969

  5. NM_027168.2 → NP_081444.1  5'-deoxynucleotidase HDDC2 isoform 1

    See identical proteins and their annotated locations for NP_081444.1

    Status: PROVISIONAL

    Source sequence(s)
    BC104361
    Consensus CDS
    CCDS23767.1
    UniProtKB/Swiss-Prot
    Q3SXD3, Q9CV20
    Related
    ENSMUSP00000000304.7, ENSMUST00000000304.14
    Conserved Domains (1) summary
    pfam13023
    Location:19 → 175
    HD_3; HD domain

RNA

  1. NR_184417.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153969

  2. NR_184418.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153969
    Related
    ENSMUST00000159194.3

  3. NR_184419.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153969

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    31189296..31204200
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155987.1 → XP_036011880.1  5'-deoxynucleotidase HDDC2 isoform X4

    Conserved Domains (1) summary
    cl21469
    Location:23 → 93
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

  2. XM_030245252.1 → XP_030101112.1  5'-deoxynucleotidase HDDC2 isoform X2

    Conserved Domains (1) summary
    pfam13023
    Location:110 → 210
    HD_3; HD domain

  3. XM_036155986.1 → XP_036011879.1  5'-deoxynucleotidase HDDC2 isoform X3

    Conserved Domains (1) summary
    cl21469
    Location:110 → 177
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3SXD3.1 GenPept UniProtKB/Swiss-Prot:Q3SXD3

Gene LinkOut

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