Emc10 ER membrane protein complex subunit 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Emc10provided by MGI
Official Full Name: ER membrane protein complex subunit 10provided by MGI
Primary source: MGI:MGI:1916933
See related: Ensembl:ENSMUSG00000008140 AllianceGenome:MGI:1916933
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Inm02; Mirta22; 2310044H10Rik; 5430410O10Rik
Summary: Predicted to contribute to membrane insertase activity. Involved in several processes, including positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; and positive regulation of p38MAPK cascade. Located in extracellular region. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Orthologous to human EMC10 (ER membrane protein complex subunit 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 166.5), ovary adult (RPKM 122.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 28.83 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (44139361..44145953, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (44489937..44496524, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Secreted EMC10 is upregulated in human obesity and its neutralizing antibody prevents diet-induced obesity in mice.
Title: Secreted EMC10 is upregulated in human obesity and its neutralizing antibody prevents diet-induced obesity in mice.
Membrane-Bound EMC10 Is Required for Sperm Motility via Maintaining the Homeostasis of Cytoplasm Sodium in Sperm.
Title: Membrane-Bound EMC10 Is Required for Sperm Motility via Maintaining the Homeostasis of Cytoplasm Sodium in Sperm.
Male mice lacking Emc10 gene are completely sterile. Emc10-null spermatozoa exhibit multiple defects including abnormal morphology, decreased motility, impaired capacitation, and impotency of acrosome reaction, thereby which are incapable of fertilizing intact or ZP-free oocytes.
Title: EMC10 governs male fertility via maintaining sperm ion balance.
Mice in which the Df(16)A deficiency is combined with a Loss-of-function Mirta22 allele show rescue of key schizophrenia-related deficits.
Title: Loss-of-function mutation in Mirta22/Emc10 rescues specific schizophrenia-related phenotypes in a mouse model of the 22q11.2 deletion.
Identify Emc10 as a previously unknown angiogenic growth factor that is produced by bone marrow-derived monocytes and macrophages as part of an endogenous adaptive response that can be enhanced therapeutically to repair the heart after myocardial infarction.
Title: EMC10 (Endoplasmic Reticulum Membrane Protein Complex Subunit 10) Is a Bone Marrow-Derived Angiogenic Growth Factor Promoting Tissue Repair After Myocardial Infarction.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to membrane insertase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	ISO Inferred from Sequence Orthology more info
involved_in tail-anchored membrane protein insertion into ER membrane	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of EMC complex	IBA Inferred from Biological aspect of Ancestor more info
part_of EMC complex	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ER membrane protein complex subunit 10

Names: UPF0510 protein INM02; hematopoietic signal peptide-containing membrane domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355107.1 → NP_001342036.1 ER membrane protein complex subunit 10 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC149607

UniProtKB/TrEMBL

A0A0X1KG67

Related

ENSMUSP00000113141.4, ENSMUST00000118515.9
NM_197991.3 → NP_932108.3 ER membrane protein complex subunit 10 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC149607

Consensus CDS

CCDS52231.2

UniProtKB/Swiss-Prot

Q3TAS6, Q3TFU1, Q5UCC3, Q5UCC5, Q8VCD8, Q99JJ8

UniProtKB/TrEMBL

A0A0X1KG67

Related

ENSMUSP00000113509.4, ENSMUST00000118808.9