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Mif4gd MIF4G domain containing [ Mus musculus (house mouse) ]

Gene ID: 69674, updated on 5-Mar-2024

Summary

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Official Symbol
Mif4gdprovided by MGI
Official Full Name
MIF4G domain containingprovided by MGI
Primary source
MGI:MGI:1916924
See related
Ensembl:ENSMUSG00000020743 AllianceGenome:MGI:1916924
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110014L05Rik; 2310075G12Rik
Summary
Predicted to enable identical protein binding activity; protein C-terminus binding activity; and translation activator activity. Predicted to be involved in regulation of translational initiation. Predicted to act upstream of or within regulation of translation. Predicted to be located in Golgi apparatus and nucleolus. Predicted to be active in cytosol. Is expressed in several structures, including brain; connective tissue; endocrine gland; genitourinary system; and trachea. Orthologous to human MIF4GD (MIF4G domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 121.7), adrenal adult (RPKM 65.9) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E2; 11 80.9 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115498744..115503795, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115607918..115612969, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene nucleoporin 85 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 3 Neighboring gene STARR-seq mESC enhancer starr_31165 Neighboring gene predicted gene, 25364 Neighboring gene STARR-positive B cell enhancer ABC_E7096 Neighboring gene mitchondrial ribosomal protein S7 Neighboring gene solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 Neighboring gene STARR-seq mESC enhancer starr_31166 Neighboring gene STARR-positive B cell enhancer mm9_chr11:115494169-115494470 Neighboring gene STARR-positive B cell enhancer ABC_E8470 Neighboring gene STARR-positive B cell enhancer ABC_E2375 Neighboring gene growth factor receptor bound protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E10730 Neighboring gene STARR-positive B cell enhancer ABC_E7098

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Assembly of the SLIP1-SLBP complex on histone mRNA requires heterodimerization and sequential binding of SLBP followed by SLIP1. Bansal N, et al. Biochemistry, 2013 Jan 22. PMID 23286197, Free PMC Article
  2. Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation. Ansseau E, et al. PLoS One, 2016. PMID 26816005, Free PMC Article
  3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables translation activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cap-dependent translational initiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of histone mRNA stem-loop binding complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MIF4G domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243584.1 → NP_001230513.1  MIF4G domain-containing protein isoform 1

    See identical proteins and their annotated locations for NP_001230513.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK150749, AL645470, BQ174854
    Consensus CDS
    CCDS25643.1
    UniProtKB/Swiss-Prot
    Q05CE9, Q3UBZ5, Q7TMH3, Q8R333
    Related
    ENSMUSP00000021087.8, ENSMUST00000021087.14
    Conserved Domains (1) summary
    cl02652
    Location:13 → 179
    MIF4G; MIF4G domain

  2. NM_001243586.1 → NP_001230515.1  MIF4G domain-containing protein isoform 2

    See identical proteins and their annotated locations for NP_001230515.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. Variants 3 and 4 encode isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AL645470
    Consensus CDS
    CCDS56818.1
    UniProtKB/TrEMBL
    A2A9W3

  3. NM_001243587.1 → NP_001230516.1  MIF4G domain-containing protein isoform 2

    See identical proteins and their annotated locations for NP_001230516.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. Variants 3 and 4 encode isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AL645470
    Consensus CDS
    CCDS56818.1
    UniProtKB/TrEMBL
    A2A9W3
    Related
    ENSMUSP00000102115.2, ENSMUST00000106506.8
    Conserved Domains (1) summary
    cl02652
    Location:13 → 160
    MIF4G; MIF4G domain

  4. NM_027162.4 → NP_081438.4  MIF4G domain-containing protein isoform 1

    See identical proteins and their annotated locations for NP_081438.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK150749, AL645470, BQ174854
    Consensus CDS
    CCDS25643.1
    UniProtKB/Swiss-Prot
    Q05CE9, Q3UBZ5, Q7TMH3, Q8R333
    Related
    ENSMUSP00000102116.3, ENSMUST00000106507.9
    Conserved Domains (1) summary
    cl02652
    Location:13 → 179
    MIF4G; MIF4G domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    115498744..115503795 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249229.4 → XP_011247531.1  MIF4G domain-containing protein isoform X3

    See identical proteins and their annotated locations for XP_011247531.1

    UniProtKB/TrEMBL
    Q8BTE1
    Conserved Domains (1) summary
    cl02652
    Location:16 → 122
    MIF4G; MIF4G domain

  2. XM_036156963.1 → XP_036012856.1  MIF4G domain-containing protein isoform X2

    UniProtKB/TrEMBL
    A2A9W3

  3. XM_036156962.1 → XP_036012855.1  MIF4G domain-containing protein isoform X1

    UniProtKB/Swiss-Prot
    Q05CE9, Q3UBZ5, Q7TMH3, Q8R333
    Conserved Domains (1) summary
    cl02652
    Location:13 → 179
    MIF4G; MIF4G domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UBZ5.1 GenPept UniProtKB/Swiss-Prot:Q3UBZ5

Gene LinkOut

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