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Psmg4 proteasome (prosome, macropain) assembly chaperone 4 [ Mus musculus (house mouse) ]

Gene ID: 69666, updated on 5-Mar-2024

Summary

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Official Symbol
Psmg4provided by MGI
Official Full Name
proteasome (prosome, macropain) assembly chaperone 4provided by MGI
Primary source
MGI:MGI:1916916
See related
Ensembl:ENSMUSG00000071451 AllianceGenome:MGI:1916916
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAC-4; mPAC4
Summary
Predicted to be involved in proteasome assembly. Part of protein-containing complex. Orthologous to human PSMG4 (proteasome assembly chaperone 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 58.6), thymus adult (RPKM 52.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 A3.3; 13 14.05 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (34346947..34362155)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (34162964..34178172)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34137 Neighboring gene predicted gene, 36500 Neighboring gene VISTA enhancer mm1605 Neighboring gene STARR-seq mESC enhancer starr_34140 Neighboring gene STARR-seq mESC enhancer starr_34143 Neighboring gene predicted gene, 36549 Neighboring gene STARR-seq mESC enhancer starr_34144 Neighboring gene solute carrier family 22, member 23 Neighboring gene STARR-seq mESC enhancer starr_34145 Neighboring gene STARR-seq mESC enhancer starr_34148 Neighboring gene VISTA enhancer mm1307 Neighboring gene predicted gene, 53791

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  2. 20S proteasome assembly is orchestrated by two distinct pairs of chaperones in yeast and in mammals. Le Tallec B, et al. Mol Cell, 2007 Aug 17. PMID 17707236
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • 2310047M15Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in proteasome assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
proteasome assembly chaperone 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101430.2 → NP_001094900.1  proteasome assembly chaperone 4 isoform b

    See identical proteins and their annotated locations for NP_001094900.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (b).
    Source sequence(s)
    AA124813, AC139242, BC070417
    Consensus CDS
    CCDS49230.1
    UniProtKB/Swiss-Prot
    P0C7N9
    Related
    ENSMUSP00000115881.2, ENSMUST00000147632.3
    Conserved Domains (1) summary
    pfam16093
    Location:30 → 97
    PAC4; Proteasome assembly chaperone 4

  2. NM_001110515.2 → NP_001103985.1  proteasome assembly chaperone 4 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an exon in the central coding region which results in a frameshift, compared to variant 2. The encoded isoform (a) is shorter and has a distinct C-terminus, compared to isoform b.
    Source sequence(s)
    AA063946, AA124813, AC139242, AK009887
    Consensus CDS
    CCDS49231.1
    UniProtKB/TrEMBL
    D3Z016
    Related
    ENSMUSP00000120336.2, ENSMUST00000124996.8
    Conserved Domains (1) summary
    pfam16093
    Location:30 → 82
    PAC4; Proteasome assembly chaperone 4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    34346947..34362155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C7N9.1 GenPept UniProtKB/Swiss-Prot:P0C7N9

Gene LinkOut

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