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Upk3bl uroplakin 3B-like [ Mus musculus (house mouse) ]

Gene ID: 69665, updated on 11-Apr-2024

Summary

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Official Symbol
Upk3blprovided by MGI
Official Full Name
uroplakin 3B-likeprovided by MGI
Primary source
MGI:MGI:1916915
See related
Ensembl:ENSMUSG00000006143 AllianceGenome:MGI:1916915
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Upk3bl1; 2310043J07Rik
Summary
Predicted to enable heme binding activity and peroxidase activity. Predicted to be involved in response to oxidative stress. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in genitourinary system. Orthologous to several human genes including UPK3BL1 (uroplakin 3B like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 15.0), CNS E18 (RPKM 1.3) and 2 other tissues See more
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Genomic context

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Location:
5 G2; 5 75.72 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (136086114..136105549)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (136057259..136076695)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene deltex 2, E3 ubiquitin ligase Neighboring gene uroplakin 3B Neighboring gene predicted gene, 40347 Neighboring gene STARR-positive B cell enhancer ABC_E2768 Neighboring gene STARR-seq mESC enhancer starr_14614 Neighboring gene RAS p21 protein activator 4 Neighboring gene microRNA 7035 Neighboring gene STARR-positive B cell enhancer ABC_E856 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide J

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uroplakin-3b-like protein 1
Names
uroplakin-3-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359361.1 → NP_001346290.1  uroplakin-3b-like protein 1 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AC087420, BC115564
    UniProtKB/Swiss-Prot
    A0AUM6, Q4KL12, Q9D701
    UniProtKB/TrEMBL
    F6X493
    Related
    ENSMUSP00000123311.3, ENSMUST00000156530.8
    Conserved Domains (1) summary
    cl06408
    Location:28 → 201
    UP_III_II; Uroplakin IIIb, IIIa and II

  2. NM_027158.1 → NP_081434.1  uroplakin-3b-like protein 1 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC115563, BX638176
    Consensus CDS
    CCDS51665.1
    UniProtKB/TrEMBL
    F6X493, F8WJ60
    Related
    ENSMUSP00000006303.5, ENSMUST00000006303.11
    Conserved Domains (1) summary
    cl06408
    Location:28 → 201
    UP_III_II; Uroplakin IIIb, IIIa and II

RNA

  1. NR_153102.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC087420
    Related
    ENSMUST00000111137.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    136086114..136105549
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240906.4 → XP_011239208.1  uroplakin-3b-like protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011239208.1

    Conserved Domains (1) summary
    cl06408
    Location:28 → 201
    UP_III_II; Uroplakin IIIb, IIIa and II

  2. XM_006504495.4 → XP_006504558.2  uroplakin-3b-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006504558.2

    Conserved Domains (1) summary
    cl06408
    Location:28 → 201
    UP_III_II; Uroplakin IIIb, IIIa and II

RNA

  1. XR_377114.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D701.1 GenPept UniProtKB/Swiss-Prot:Q9D701

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