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Exosc8 exosome component 8 [ Mus musculus (house mouse) ]

Gene ID: 69639, updated on 11-Apr-2024

Summary

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Official Symbol
Exosc8provided by MGI
Official Full Name
exosome component 8provided by MGI
Primary source
MGI:MGI:1916889
See related
Ensembl:ENSMUSG00000027752 AllianceGenome:MGI:1916889
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CIP3; mKIAA4013; 2310032N20Rik
Summary
Predicted to enable identical protein binding activity and mRNA 3'-UTR AU-rich region binding activity. Predicted to be involved in RNA metabolic process. Predicted to act upstream of or within rRNA processing. Predicted to be located in chromosome; cytosol; and nuclear lumen. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia. Orthologous to human EXOSC8 (exosome component 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 31.7), liver E14 (RPKM 25.7) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 C; 3 25.6 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (54636099..54642469, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (54728679..54735364, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:54393991-54394215 Neighboring gene predicted gene, 40050 Neighboring gene REX1, RNA exonuclease 1 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_07679 Neighboring gene STARR-positive B cell enhancer ABC_E8986 Neighboring gene STARR-seq mESC enhancer starr_07681 Neighboring gene SPT20 SAGA complex component Neighboring gene STARR-positive B cell enhancer ABC_E7912 Neighboring gene STARR-positive B cell enhancer ABC_E10181 Neighboring gene ALG5 dolichyl-phosphate beta-glucosyltransferase Neighboring gene SMAD family member 9 Neighboring gene STARR-seq mESC enhancer starr_07686

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Alström syndrome protein, ALMS1, interacts with α-actinin and components of the endosome recycling pathway. Collin GB, et al. PLoS One, 2012. PMID 22693585, Free PMC Article
  2. Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling. Ulmke PA, et al. Development, 2021 Feb 8. PMID 33462115, Free PMC Article
  3. The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L. Tomecki R, et al. EMBO J, 2010 Jul 21. PMID 20531386, Free PMC Article
  4. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
  5. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4013

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR AU-rich region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR AU-rich region binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in TRAMP-dependent tRNA surveillance pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in U1 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in U4 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in U5 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear mRNA surveillance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear polyadenylation-dependent rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of cytoplasmic exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic exosome (RNase complex) NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of exosome (RNase complex) ISO
Inferred from Sequence Orthology
more info
  
part_of exosome (RNase complex) NAS
Non-traceable Author Statement
more info
 PubMed 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear exosome (RNase complex) NAS
Non-traceable Author Statement
more info
 PubMed 
part_of nucleolar exosome (RNase complex) NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
exosome complex component RRP43
Names
exosome complex exonuclease RRP43
ribosomal RNA-processing protein 43
NP_001157042.1
NP_081424.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163570.2 → NP_001157042.1  exosome complex component RRP43 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC100927
    UniProtKB/TrEMBL
    Q6PCW8
    Conserved Domains (2) summary
    cd11369
    Location:6 → 270
    RNase_PH_RRP43; RRP43 subunit of eukaryotic exosome
    PRK04282
    Location:12 → 276
    PRK04282; exosome complex RNA-binding protein Rrp42; Provisional

  2. NM_027148.4 → NP_081424.3  exosome complex component RRP43 isoform 2

    See identical proteins and their annotated locations for NP_081424.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC100927
    Consensus CDS
    CCDS17352.1
    UniProtKB/Swiss-Prot
    Q9D753
    UniProtKB/TrEMBL
    Q546F8, Q6PCW8
    Related
    ENSMUSP00000029316.10, ENSMUST00000029316.16
    Conserved Domains (2) summary
    cd11369
    Location:6 → 266
    RNase_PH_RRP43; RRP43 subunit of eukaryotic exosome
    PRK04282
    Location:12 → 272
    PRK04282; exosome complex RNA-binding protein Rrp42; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    54636099..54642469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D753.1 GenPept UniProtKB/Swiss-Prot:Q9D753

Gene LinkOut

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