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Clybl citrate lyase beta like [ Mus musculus (house mouse) ]

Gene ID: 69634, updated on 21-Apr-2024

Summary

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Official Symbol
Clyblprovided by MGI
Official Full Name
citrate lyase beta likeprovided by MGI
Primary source
MGI:MGI:1916884
See related
Ensembl:ENSMUSG00000025545 AllianceGenome:MGI:1916884
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Clb; 0610033J05Rik; 2310014M14Rik
Summary
Enables (S)-citramalyl-CoA lyase activity. Involved in positive regulation of cobalamin metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human CLYBL (citramalyl-CoA lyase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 9.1), heart adult (RPKM 8.2) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 E5; 14 65.86 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (122408289..122639646)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (122170994..122402234)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene transmembrane 9 superfamily member 2 Neighboring gene STARR-seq mESC enhancer starr_37749 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene RIKEN cDNA 1700108J01 gene Neighboring gene STARR-seq mESC enhancer starr_37753 Neighboring gene STARR-seq mESC enhancer starr_37767 Neighboring gene predicted gene 5089 Neighboring gene STARR-seq mESC enhancer starr_37772 Neighboring gene predicted gene, 25464 Neighboring gene STARR-seq mESC enhancer starr_37773 Neighboring gene STARR-seq mESC enhancer starr_37776 Neighboring gene predicted gene, 53847 Neighboring gene zinc finger protein of the cerebellum 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning of novel mouse and human putative citrate lyase beta-subunit. Morikawa J, et al. Biochem Biophys Res Commun, 2001 Dec 21. PMID 11741334
  2. The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B(12). Shen H, et al. Cell, 2017 Nov 2. PMID 29056341, Free PMC Article
  3. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
  4. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables (S)-citramalyl-CoA lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables (S)-citramalyl-CoA lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables (S)-citramalyl-CoA lyase activity ISO
Inferred from Sequence Orthology
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables malate synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of cobalamin metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein homotrimerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cobalamin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cobalamin metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cobalamin metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
citramalyl-CoA lyase, mitochondrial
Names
(3S)-malyl-CoA thioesterase
beta-methylmalate synthase
citrate lyase subunit beta-like protein, mitochondrial
malate synthase
NP_083832.2
XP_030103854.1
XP_030103856.1
XP_030103857.1
XP_036014733.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029556.3 → NP_083832.2  citramalyl-CoA lyase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_083832.2

    Status: VALIDATED

    Source sequence(s)
    AC164315, AK009345, CX202248
    Consensus CDS
    CCDS27346.1
    UniProtKB/Swiss-Prot
    Q8R4N0, Q9D7D0
    Related
    ENSMUSP00000026625.6, ENSMUST00000026625.7
    Conserved Domains (1) summary
    COG2301
    Location:45 → 335
    CitE; Citrate lyase beta subunit [Carbohydrate transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    122408289..122639646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158840.1 → XP_036014733.1  citramalyl-CoA lyase, mitochondrial isoform X1

  2. XM_030247994.1 → XP_030103854.1  citramalyl-CoA lyase, mitochondrial isoform X2

    Conserved Domains (1) summary
    COG2301
    Location:1 → 204
    CitE; Citrate lyase beta subunit [Carbohydrate transport and metabolism]

  3. XM_030247997.2 → XP_030103857.1  citramalyl-CoA lyase, mitochondrial isoform X3

    Conserved Domains (1) summary
    COG2301
    Location:1 → 174
    CitE; Citrate lyase beta subunit [Carbohydrate transport and metabolism]

  4. XM_030247996.1 → XP_030103856.1  citramalyl-CoA lyase, mitochondrial isoform X3

    Conserved Domains (1) summary
    COG2301
    Location:1 → 174
    CitE; Citrate lyase beta subunit [Carbohydrate transport and metabolism]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R4N0.2 GenPept UniProtKB/Swiss-Prot:Q8R4N0

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