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Pcgf3 polycomb group ring finger 3 [ Mus musculus (house mouse) ]

Gene ID: 69587, updated on 30-Apr-2024

Summary

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Official Symbol
Pcgf3provided by MGI
Official Full Name
polycomb group ring finger 3provided by MGI
Primary source
MGI:MGI:1916837
See related
Ensembl:ENSMUSG00000033623 AllianceGenome:MGI:1916837
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rnf3; DONG1; RNF3A; E430039C14; 2310035N15Rik; D630042K08Rik
Summary
Predicted to enable metal ion binding activity. Involved in histone H2A-K119 monoubiquitination and inactivation of X chromosome by genetic imprinting. Part of PcG protein complex. Colocalizes with X chromosome. Is expressed in several structures, including branchial arch; central nervous system; limb; otocyst; and urinary system. Orthologous to human PCGF3 (polycomb group ring finger 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 11.1), CNS E14 (RPKM 9.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 53.13 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108609082..108654842)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108461259..108506976)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9648 Neighboring gene predicted gene, 34319 Neighboring gene ATP synthase membrane subunit e Neighboring gene solute carrier family 49 member 3 Neighboring gene STARR-positive B cell enhancer ABC_E6360 Neighboring gene STARR-seq mESC enhancer starr_13909 Neighboring gene ribosomal protein L34 pseudogene Neighboring gene complexin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Bivalent-histone-marked immediate-early gene regulation is vital for VEGF-responsive angiogenesis. Kanki Y, et al. Cell Rep, 2022 Feb 8. PMID 35139389
  2. Polycomb group RING finger proteins 3/5 activate transcription via an interaction with the pluripotency factor Tex10 in embryonic stem cells. Zhao W, et al. J Biol Chem, 2017 Dec 29. PMID 29054931, Free PMC Article
  3. Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression. Fursova NA, et al. Mol Cell, 2019 Jun 6. PMID 31029541, Free PMC Article
  4. Essential Role for Polycomb Group Protein Pcgf6 in Embryonic Stem Cell Maintenance and a Noncanonical Polycomb Repressive Complex 1 (PRC1) Integrity. Zhao W, et al. J Biol Chem, 2017 Feb 17. PMID 28049731, Free PMC Article
  5. hnRNPK Recruits PCGF3/5-PRC1 to the Xist RNA B-Repeat to Establish Polycomb-Mediated Chromosomal Silencing. Pintacuda G, et al. Mol Cell, 2017 Dec 7. PMID 29220657, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the knockout of Pcgf3, Pcgf5, or both resulted in a 39, 29, and 52% decrease, respectively, in global levels of H2AK119ub1 as compared with wild-type cells, as evidenced by Western blotting. In contrast, no similar change was observed for H3K27me3.
    Title: Polycomb group RING finger proteins 3/5 activate transcription via an interaction with the pluripotency factor Tex10 in embryonic stem cells.
  2. Authors conclude that RYBP/YAF2 binding to H2AK119u1 likely underpins the transient interaction of noncanonical PRC1 complexes with Xist RNA domains but does not account for stable interaction of PCGF3/5-PRC1 complexes.
    Title: PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation.
  3. hnRNPK recruits PCGF3/5-PRC1 to the Xist RNA B-repeat to establish polycomb-mediated chromosomal silencing.
    Title: hnRNPK Recruits PCGF3/5-PRC1 to the Xist RNA B-Repeat to Establish Polycomb-Mediated Chromosomal Silencing.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1) 
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone H2AK119 ubiquitin ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in random inactivation of X chromosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of PRC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PcG protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with X chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
polycomb group RING finger protein 3
Names
RING finger protein 3A
ring finger protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001377000.1 → NP_001363929.1  polycomb group RING finger protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC133896, AC158912
    Conserved Domains (2) summary
    cd16735
    Location:14 → 60
    RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cd17083
    Location:153 → 226
    RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

  2. NM_001377001.1 → NP_001363930.1  polycomb group RING finger protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC133896, AC158912
    UniProtKB/Swiss-Prot
    Q8BTQ0, Q8BZT0
    Conserved Domains (2) summary
    cd16735
    Location:14 → 60
    RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cd17083
    Location:153 → 235
    RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

  3. NM_172716.5 → NP_766304.2  polycomb group RING finger protein 3 isoform 1

    See identical proteins and their annotated locations for NP_766304.2

    Status: VALIDATED

    Source sequence(s)
    AC133896, AC158912
    Consensus CDS
    CCDS19512.1
    UniProtKB/Swiss-Prot
    Q8BTQ0, Q8BZT0
    Related
    ENSMUSP00000041790.6, ENSMUST00000046975.12
    Conserved Domains (2) summary
    cd16735
    Location:14 → 60
    RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cd17083
    Location:153 → 235
    RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    108609082..108654842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165475.1 → XP_036021368.1  polycomb group RING finger protein 3 isoform X1

    Conserved Domains (2) summary
    cd16735
    Location:14 → 60
    RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cd17083
    Location:153 → 226
    RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

  2. XM_036165477.1 → XP_036021370.1  polycomb group RING finger protein 3 isoform X3

    Conserved Domains (2) summary
    cd16735
    Location:14 → 60
    RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cl28922
    Location:153 → 203
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  3. XM_030254794.2 → XP_030110654.1  polycomb group RING finger protein 3 isoform X2

    UniProtKB/Swiss-Prot
    Q8BTQ0, Q8BZT0
    Conserved Domains (2) summary
    cd16735
    Location:14 → 60
    RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cd17083
    Location:153 → 235
    RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

  4. XM_036165476.1 → XP_036021369.1  polycomb group RING finger protein 3 isoform X1

    Conserved Domains (2) summary
    cd16735
    Location:14 → 60
    RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cd17083
    Location:153 → 226
    RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BTQ0.1 GenPept UniProtKB/Swiss-Prot:Q8BTQ0

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