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Cmbl carboxymethylenebutenolidase homolog [ Mus musculus (house mouse) ]

Gene ID: 69574, updated on 5-Mar-2024

Summary

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Official Symbol
Cmblprovided by MGI
Official Full Name
carboxymethylenebutenolidase homologprovided by MGI
Primary source
MGI:MGI:1916824
See related
Ensembl:ENSMUSG00000022235 AllianceGenome:MGI:1916824
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310016A09Rik
Summary
Predicted to enable hydrolase activity. Predicted to be located in cytoplasm. Is expressed in adrenal medulla and nervous system. Orthologous to human CMBL (carboxymethylenebutenolidase homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 53.1), kidney adult (RPKM 44.6) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 B2; 15 13.0 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (31565314..31590266)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (31565342..31590119)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10847 Neighboring gene ropporin 1-like Neighboring gene ubiquitin-conjugating enzyme E2 variant 2 pseudogene Neighboring gene predicted gene, 49208 Neighboring gene membrane associated ring-CH-type finger 6 Neighboring gene STARR-seq mESC enhancer starr_38292 Neighboring gene STARR-positive B cell enhancer ABC_E4130 Neighboring gene chaperonin containing TCP1 subunit 5 Neighboring gene ATP synthase C subunit lysine N-methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A gene expression resource generated by genome-wide lacZ profiling in the mouse. Tuck E, et al. Dis Model Mech, 2015 Nov. PMID 26398943, Free PMC Article
  2. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
carboxymethylenebutenolidase homolog
Names
carboxymethylenebutenolidase-like (Pseudomonas)
NP_853619.1
XP_006520239.1
XP_006520240.1
XP_006520241.1
XP_030104612.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181588.4 → NP_853619.1  carboxymethylenebutenolidase homolog

    See identical proteins and their annotated locations for NP_853619.1

    Status: VALIDATED

    Source sequence(s)
    AI426411, BB863032, BM899338, BY793531
    Consensus CDS
    CCDS27410.1
    UniProtKB/Swiss-Prot
    Q8C1N1, Q8R1G2
    UniProtKB/TrEMBL
    A0A2I3BPJ4
    Related
    ENSMUSP00000070314.7, ENSMUST00000070918.14
    Conserved Domains (1) summary
    COG0412
    Location:30 → 244
    DLH; Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    31565314..31590266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520176.4 → XP_006520239.1  carboxymethylenebutenolidase homolog isoform X1

    See identical proteins and their annotated locations for XP_006520239.1

    UniProtKB/Swiss-Prot
    Q8C1N1, Q8R1G2
    UniProtKB/TrEMBL
    A0A2I3BPJ4
    Related
    ENSMUSP00000153812.2, ENSMUST00000226951.2
    Conserved Domains (1) summary
    COG0412
    Location:30 → 244
    DLH; Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism]

  2. XM_030248752.2 → XP_030104612.1  carboxymethylenebutenolidase homolog isoform X2

    UniProtKB/TrEMBL
    E0CXH4
    Conserved Domains (1) summary
    cl21494
    Location:30 → 157
    Abhydrolase; alpha/beta hydrolases

  3. XM_006520178.5 → XP_006520241.1  carboxymethylenebutenolidase homolog isoform X2

    UniProtKB/TrEMBL
    E0CXH4
    Conserved Domains (1) summary
    cl21494
    Location:30 → 157
    Abhydrolase; alpha/beta hydrolases

  4. XM_006520177.5 → XP_006520240.1  carboxymethylenebutenolidase homolog isoform X1

    See identical proteins and their annotated locations for XP_006520240.1

    UniProtKB/Swiss-Prot
    Q8C1N1, Q8R1G2
    UniProtKB/TrEMBL
    A0A2I3BPJ4
    Conserved Domains (1) summary
    COG0412
    Location:30 → 244
    DLH; Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R1G2.1 GenPept UniProtKB/Swiss-Prot:Q8R1G2

Gene LinkOut

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