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Mfsd3 major facilitator superfamily domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 69572, updated on 5-Mar-2024

Summary

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Official Symbol
Mfsd3provided by MGI
Official Full Name
major facilitator superfamily domain containing 3provided by MGI
Primary source
MGI:MGI:1916822
See related
Ensembl:ENSMUSG00000019080 AllianceGenome:MGI:1916822
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310010G13Rik
Summary
Predicted to enable solute:proton symporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human MFSD3 (major facilitator superfamily domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 19.7), mammary gland adult (RPKM 12.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 D3; 15 36.28 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76585742..76588439)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76701542..76704239)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5491 Neighboring gene protein phosphatase 1, regulatory subunit 16A Neighboring gene STARR-seq mESC enhancer starr_39060 Neighboring gene glutamic pyruvic transaminase, soluble Neighboring gene RecQ protein-like 4 Neighboring gene STARR-positive B cell enhancer ABC_E7385 Neighboring gene leucine rich repeat containing 14 Neighboring gene leucine rich repeat containing 24 Neighboring gene RIKEN cDNA C030006K11 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake. Perland E, et al. J Mol Neurosci, 2017 Feb. PMID 27981419, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protein expression of MFSD3 is in mouse brain regions is specifically affected by altered nutrient uptake.
    Title: The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
major facilitator superfamily domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027122.3 → NP_081398.2  major facilitator superfamily domain-containing protein 3

    See identical proteins and their annotated locations for NP_081398.2

    Status: PROVISIONAL

    Source sequence(s)
    AK089539
    Consensus CDS
    CCDS27587.1
    UniProtKB/Swiss-Prot
    Q5U419, Q8VED1, Q9D7F8
    UniProtKB/TrEMBL
    A0A0R4J004
    Related
    ENSMUSP00000019224.8, ENSMUST00000019224.9
    Conserved Domains (1) summary
    cl21472
    Location:8 → 402
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76585742..76588439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U419.1 GenPept UniProtKB/Swiss-Prot:Q5U419

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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