Nmrk2 nicotinamide riboside kinase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nmrk2provided by MGI
Official Full Name: nicotinamide riboside kinase 2provided by MGI
Primary source: MGI:MGI:1916814
See related: Ensembl:ENSMUSG00000004939 AllianceGenome:MGI:1916814
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mibp; Itgb1bp3; 2310015C21Rik
Summary: Predicted to enable ribosylnicotinamide kinase activity and ribosylnicotinate kinase activity. Acts upstream of or within negative regulation of myoblast differentiation. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including cardiovascular system; lung; skeletal muscle tissue; and thymus. Orthologous to human NMRK2 (nicotinamide riboside kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in heart adult (RPKM 4.7), mammary gland adult (RPKM 1.1) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (81034004..81037871, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (81198170..81202265, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nicotinamide riboside kinase-2 regulates metabolic adaptation in the ischemic heart.
Title: Nicotinamide riboside kinase-2 regulates metabolic adaptation in the ischemic heart.
Induction of the nicotinamide riboside kinase NAD(+) salvage pathway in a model of sarcoplasmic reticulum dysfunction.
Title: Induction of the nicotinamide riboside kinase NAD(+) salvage pathway in a model of sarcoplasmic reticulum dysfunction.
NMRK2 Gene Is Upregulated in Dilated Cardiomyopathy and Required for Cardiac Function and NAD Levels during Aging.
Title: NMRK2 Gene Is Upregulated in Dilated Cardiomyopathy and Required for Cardiac Function and NAD Levels during Aging.
NRK-2 deficiency promotes post-MI scar expansion, rapid LV chamber dilatation, cardiac dysfunction and fibrosis possibly due to increased p38alpha activation.
Title: Nicotinamide riboside kinase-2 alleviates ischemia-induced heart failure through P38 signaling.
Nrk2 knockout mice develop normally and show subtle alterations to their NAD+ metabolome and expression of related genes in skeletal muscle. NRK2 KO myotubes revealed redundancy in the NRK1/2 dependent metabolism of nicotinamide riboside to NAD+.
Title: Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells.
functions in the control of myogenic differentiation by regulating alpha7beta1 integrin-mediated cell interactions with laminin matrix and intracellular signaling through paxillin.
Title: The muscle integrin binding protein (MIBP) interacts with alpha7beta1 integrin and regulates cell adhesion and laminin matrix deposition.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (8)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Itgb1bp3 (e-PCR), detects polymorphism
- UniSTS:546833

NoName (e-PCR)
- UniSTS:494977

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosylnicotinamide kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribosylnicotinamide kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosylnicotinate kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of myoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pyridine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular anatomical structure	IPI Inferred from Physical Interaction more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nicotinamide riboside kinase 2

Names: NRK 2; RNK 2; integrin beta 1 binding protein 3; muscle integrin-binding protein; muscle-specific beta 1 integrin binding protein; nicotinic acid riboside kinase 2; nmR-K 2; ribosylnicotinamide kinase 2; ribosylnicotinic acid kinase 2

NP_081396.1

EC 2.7.1.173

EC 2.7.1.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027120.2 → NP_081396.1 nicotinamide riboside kinase 2

See identical proteins and their annotated locations for NP_081396.1

Status: PROVISIONAL

Source sequence(s)

AK137483

Consensus CDS

CCDS24046.1

UniProtKB/Swiss-Prot

Q0VEG2, Q3UV96, Q9D7C9

Related

ENSMUSP00000005069.7, ENSMUST00000005069.8

Conserved Domains (1) summary

cd02024
Location:4 → 164

NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...