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Lyg1 lysozyme G-like 1 [ Mus musculus (house mouse) ]

Gene ID: 69541, updated on 11-Apr-2024

Summary

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Official Symbol
Lyg1provided by MGI
Official Full Name
lysozyme G-like 1provided by MGI
Primary source
MGI:MGI:1916791
See related
Ensembl:ENSMUSG00000026085 AllianceGenome:MGI:1916791
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2300002O18Rik
Summary
Predicted to enable lysozyme activity. Predicted to be involved in defense response to Gram-positive bacterium. Predicted to be active in extracellular region. Orthologous to human LYG1 (lysozyme g1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 4.2) and lung adult (RPKM 1.3) See more
Orthologs
human all
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Genomic context

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See Lyg1 in Genome Data Viewer
Location:
1 B; 1 16.29 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (37985819..37996840, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (37946738..37957759, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L30 Neighboring gene lysozyme G-like 2 Neighboring gene STARR-seq mESC enhancer starr_00687 Neighboring gene thioredoxin domain containing 9 Neighboring gene STARR-positive B cell enhancer ABC_E3269 Neighboring gene STARR-positive B cell enhancer ABC_E10006 Neighboring gene eukaryotic translation initiation factor 5B Neighboring gene STARR-seq mESC enhancer starr_00688 Neighboring gene predicted gene, 34448

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LYG1 Deficiency Attenuates the Severity of Acute Graft-Versus-Host Disease via Skewing Allogeneic T Cells Polarization Towards Treg Cells. Liu H, et al. Front Immunol, 2021. PMID 34262560, Free PMC Article
  2. LYG1 exerts antitumor function through promoting the activation, proliferation, and function of CD4(+) T cells. Liu H, et al. Oncoimmunology, 2017. PMID 28507796, Free PMC Article
  3. Molecular evolution of vertebrate goose-type lysozyme genes. Irwin DM, et al. J Mol Evol, 2003 Feb. PMID 12574869
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LYG1 Deficiency Attenuates the Severity of Acute Graft-Versus-Host Disease via Skewing Allogeneic T Cells Polarization Towards Treg Cells.
    Title: LYG1 Deficiency Attenuates the Severity of Acute Graft-Versus-Host Disease via Skewing Allogeneic T Cells Polarization Towards Treg Cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables lysozyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lysozyme g-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027111.3 → NP_081387.1  lysozyme g-like protein 1 precursor

    See identical proteins and their annotated locations for NP_081387.1

    Status: PROVISIONAL

    Source sequence(s)
    AK009014
    Consensus CDS
    CCDS35543.1
    UniProtKB/Swiss-Prot
    Q9D7Q0
    UniProtKB/TrEMBL
    F8WIW2, Q0VE18
    Related
    ENSMUSP00000110544.2, ENSMUST00000114894.2
    Conserved Domains (1) summary
    cl00222
    Location:38 → 195
    lysozyme_like; lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases. ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    37985819..37996840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496258.1 → XP_006496321.1  lysozyme g-like protein 1 isoform X1

    UniProtKB/TrEMBL
    F8WIW2
    Conserved Domains (1) summary
    cl00222
    Location:38 → 158
    Lyz-like; lysozyme-like domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D7Q0.1 GenPept UniProtKB/Swiss-Prot:Q9D7Q0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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